Molecular Evolution and the Immunoglobulin Gene Superfamily
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The immunoglobulin gene superfamily is a collection of multigene families and single gene members, all evolutionarily related through a shared immunoglobulin homology unit. The superfamily includes more than 100 different proteins with functions generally related to molecular cell-surface recognition, including immune recognition, grow factor receptors, cell adhesion molecules of nervous and nonnervous tissues, and extracellular matrix components. The gene superfamily probably arose with the evolution of Metazoa. It has provided fundamental insights into the genetic mechanisms responsible for rapid evolutionary changes.
KeywordsMajor Histocompatibility Complex Major Histocompatibility Complex Class Multigene Family Major Histocompatibility Complex Molecule Major Histocompatibility Complex Gene
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- 11.Williams AF, Barclay AN (1989) In: Honjo T, Alt FW, Rabbits TH (eds) The immunoglobulin gene superfamily in immunoglobulin genes. Academic, London, pp 361–387Google Scholar
- 13.Gould SJ (1989) Wonderful life: The Burgess shale and the nature of history. Norton, New YorkGoogle Scholar
- 14.Hunkapiller T, Goverman J, Koop BF, Hood L (1990) Implications of the diversity of the immunoglobulin gene superfamily. Cold Spring Harbor Symp Quant BiolGoogle Scholar
- 15.Hildeman, WH, Bigger CH, Johnson JS, Jokiel PL (1980) Characteristics of immune memory in invertebrates. Dev Comp Immunol 10: 9Google Scholar
- 16.Ohno S (1970) Gene duplication as an evolutionary force. Proceedings of the 17th colloquium at Brugge, Belgium: Protides of the biological fluids, pp 39–42Google Scholar