Summary
By “neutral evolution” I mean the process of substitutions of selectively neutral (i. e., selectively equivalent) mutants in the species through random genetic drift under continued mutation pressure. According to the neutral theory of molecular evolution, the great majority of evolutionary changes at the molecular level (such as DNA base substitutions and amino acid replacements) are the result of such neutral evolution, rather than the result of Darwinian adaptive evolution. The neutral theory also claims that most of the genetic variability within species at the molecular level (such as protein and DNA polymorphism) is selectively neutral or very nearly neutral so that the majority of polymorphic alleles are maintained in the species by the balance between mutational input and random extinction, but not by balancing natural selection. The neutral theory is based on simple assumptions, and this enables us to develop mathematical theories based on population genetics to treat these phenomena of evolution and variation in quantitative terms. This permits the theory to be tested against actual observations. In this paper, I review some recent data strongly suggesting neutral evolution, including such topics as pseudoglobin genes of the mouse, αA-crystallin genes of the blind mole rat and genes of RNA viruses. I also discuss some problems of DNA polymorphism in the light of the neutral theory. Finally, I emphasize the importance of population genetics in understanding the mechanisms of molecular evolution. It is concluded that, since the origin of life on Earth, the great majority of evolutionary changes have been neutral rather than Darwinian.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Kimura M (1968) Evolutionary rate at the molecular level. Nature 217: 624–626
Kimura M (1983) The neutral theory of molecular evolution. Cambridge University Press, Cambridge
Kimura M, Crow JF (1964) The number of alleles that can be maintained in a finite population. Genetics 49: 725–738
Kimura M (1968) Genetic variability maintained in a finite population due to mutational production of neutral and nearly neutral alleles. Genet Res 11: 247–269
Kimura M (1969) The number of heterozygous nucleotide sites maintained in a finite population due to steady flux of mutations. Genetics 61: 893–903
Kimura M (1971) Theoretical foundation of population genetics at the molecular level. Theor Popul Biol 2: 174–208
Nei M (1987) Molecular evolutionary genetics. Columbia University Press, New York
Ohta T, Aoki K (eds) (1985) Population genetics and molecular evolution. Japan Scientific Societies, Tokyo and Springer, Berlin
Takahata N, Crow JF (eds) (1990) Population biology of genes and molecules. Baifukan, Tokyo
Kimura M, Ohta T (1971) Theoretical aspects of population genetics. Princeton University Press, Princeton
Kimura M, Ohta T (1969) The average number of generations until fixation of a mutant gene in a finite population. Genetics 61: 763–771
Kimura M, Ohta T (1974) On some principles governing molecular evolution. Proc Natl Acad Sci USA 71: 2848–2852
Kimura M (1977) Preponderance of synonymous changes as evidence for the neutral theory of molecular evolution. Nature 267: 275–276
Miyata T, Yasunaga T (1981) Rapidly evolving mouse a-globin-related pseudogene and its evolutionary history. Proc Natl Acad Sci USA 78: 450–453
Li W-H, Gojobori T, Nei M (1981) Pseudogenes as a paradigm of neutral evolution. Nature 292: 237–239
Wu C-I, Li W-H (1985) Evidence for higher rates of nucleotide substitution in rodents than in man. Proc Natl Acad Sci USA 82: 1741–1745
Kikuno R, Hayashida H, Miyata T (1985) Rapid rate of rodent evolution. Proc Jpn Acad 61 (B): 153–156
Kimura M (1987) Molecular evolutionary clock and the neutral theory. J Mol Evol 26: 24–33
Crow JF, Kimura M (1970) An introduction to population genetics theory. Harper and Row, New York, pp 297–312
Hendriks W, Leunissen J, Nevo E, Bloemendal H, dejong WW (1987) The lens protein αA-crystallin of the blind mole rat, Spalax ehrenbergv. Evolutionary change and functional constraints. Proc Natl Acad Sci USA 84: 5320–5324
Stebbins GL, Hartl DL (1988) Comparative evolution: Latent potentials for anagenetic advance. Proc Natl Acad Sci USA 85: 5141–5145
Saitou N, Nei M (1986) Polymorphism and evolution of influenza A virus genes. Mol Biol Evol 3: 57–74
Hayashida H, Toh H, Kikuno R, Miyata T (1985) Evolution of influenza virus genes. Mol Biol Evol 2: 289–303
Gojobori T, Moriyama EN, Kimura M (in press) Molecular clock of viral evolution, and the neutral theory. Proc Natl Acad Sci USA
Gojobori T, Yokoyama S (1987) Molecular evolutionary rates of oncogenes. J Mol Evol 26: 148–156
Yokoyama S, Gojobori T (1987) Molecular evolution and phylogeny of the human AIDS viruses LAV, HTLV-III, and ARV. J Mol Evol 24: 330–336
Yokoyama S, Moriyama EN, Gojobori T (1987) Molecular phylogeny of the human immunodeficiency and related retroviruses. Proc Jpn Acad 63 (B): 147–150
Penny D (1988) Origins of the AIDS virus. Nature 339: 494–495
Li W-H, Tanimura M, Sharp PM (1988) Rates and dates of divergence between AIDS virus nucleotide sequences. Mol Biol Evol 5: 315 - 330
Harris H, Hopkinson DA (1972) Average heterozygosity per locus in man: An estimate based on the incidence of enzyme polymorphisms. Ann Hum Genet 36: 9–20
Dobzhansky T (1970) Genetics of the evolutionary process. Columbia University Press, New York
Kimura M (1974) Gene pool of higher organisms as a product of evolution. Cold Spring Harbor Symp Quant Biol 38: 515–524
Kazazian HH Jr, Chakravarti A, Orkin SH, Antonarakis SE (1983) DNA polymorphisms in the human ß globin gene cluster. In: Nei M, Koehn RK (eds) Evolution of genes and proteins. Sinauer, Sunderland, pp 137–146
Nei M, Tajima F (1981) DNA polymorphism detected by restriction endonucleases. Genetics 97: 145–163
Kimura M (1983) Rare variant alleles in the light of the neutral theory. Mol Biol Evol 1: 84–93
Satta Y, Matsuura ET, Chigusa SI (1990) Mitochondrial DNA polymorphism in Drosophila melanogaster. In: Takahata N, Crow JF (eds) Population biology of genes and molecules. Baifukan, Tokyo, pp 57–73
Brown WM (1983) Evolution of animal mitochondrial DNA. In: Nei M, Koehn RK (eds) Evolution of genes and proteins. Sinauer, Sunderland, pp 62–88
Horai S (1991) Molecular phylogeny and evolution of human mitochondrial DNA. In: Kimura M, Takahata N (eds) New aspects of the genetics of molecular evolution. Japan Sci Soc. Press, Tokyo/Springer-Verlag, Berlin
Van Valen L (1974) Molecular evolution as predicted by natural selection. J Mol Evol 3: 89–101
Watson JD, Hopkins NH, Roberts JW, Steiz JA, Weiner AM (1987) Molecular Biology of the Gene, 4th edn. Benjamin and Cummings, New York
Zuckerkandl E (1976) Evolutionary processes and evolutionary noise at the molecular level, II. A selectionist model for random fixations in proteins. J Mol Evol 7: 269–311
Muto A, Yamao F, Kawauchi Y, Osawa S (1985) Codon usage in Mycoplasma capricolum. Proc Jpn Acad 61 (B): 12–15
Yamao F, Muto A, Kawauchi Y, Iwami M, Iwagami S, Azumi Y, Osawa S (1985) UGA is read as tryptophan in Mycoplasma capricolum. Proc Natl Acad Sci USA 82: 2306–2309
Jukes TH (1985) A change in the genetic code in Mycoplasma capricolum. J Mol Evol 22: 361–362
Dyson F (1985) Origins of life. Cambridge University Press, Cambridge
Cairns-Smith AG (1986) Chirality and the common ancestor effect. Chem Br 22: 559–561
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Tokyo
About this chapter
Cite this chapter
Kimura, M. (1991). Neutral Evolution. In: Osawa, S., Honjo, T. (eds) Evolution of Life. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68302-5_5
Download citation
DOI: https://doi.org/10.1007/978-4-431-68302-5_5
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68304-9
Online ISBN: 978-4-431-68302-5
eBook Packages: Springer Book Archive