Evolutionary Relationships of Human Populations at the Molecular Level

  • Masatoshi Nei
  • Tatsuya Ota


All humans belong to the same species, Homo sapiens; yet there are many populations, or ethnic groups, that can be distinguished from each other in terms of morphological characters. The broad division into three major ethnic groups, Caucasoid, Mongoloid, and Negroid, is generally accepted; many anthropologists add two more major ethnic groups, Amerind (American Indians) and Australoid. However, how these ethnic groups evolved remains controversial, and the evolutionary relationships of populations within these groups are yet to be studied.


Evolutionary Relationship Dark Skin UPGMA Dendrogram Major Ethnic Group Coalescence Time 


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  1. 1.
    Cavalli-Sforza LL, Edwards AWF (1964) Analysis of human evolution. In Geerts SJ (ed) Genetics today, vol. 3 Pergamon, Oxford, pp 923–933Google Scholar
  2. 2.
    Edwards AWF, Cavalli-Sforza LL (1964) Reconstruction of evolutionary trees. System Assoc Pub 6: 67–76Google Scholar
  3. 3.
    Nei M, Roychoudhury AK (1974) Genie variation within and between the three major races of man, Caucasoids, Negroids, and Mongoloids. Am J Hum Genet 26: 421—443PubMedGoogle Scholar
  4. 4.
    Nei M, Roychoudhury AK (1982) Genetic relationship and evolution of human races. Evol Biol 14: 1–59Google Scholar
  5. 5.
    Cavalli-Sforza LL, Piazza A, Menozzi P, Mountain J (1988) Reconstruction of human evolution: Bringing together genetic, archaeological, and linguistic data. Proc Natl Acad Sci USA 85: 6002–6006PubMedCrossRefGoogle Scholar
  6. 6.
    Bowcock AM, Bucci C, Hebert JM, Kidd JR, Kidd KK, Friedlaender JS, Cavalli-Sforza LL (1987) Study of 47 DNA markers in five populations from four continents. Gene Geogr 1: 47–64PubMedGoogle Scholar
  7. 7.
    Roychoudhury AK, Nei M (1988) Human polymorphic genes: World distribution. Oxford University Press, OxfordGoogle Scholar
  8. 8.
    Nei M, Livshits G (1989) Genetic relationships of Europeans, Asians, and Africans and the origin of modern Homo sapiens. Hum Hered 39: 276–281PubMedCrossRefGoogle Scholar
  9. 9.
    Nei M, Livshits G, Ota T (to be published) Genetic variation and evolution of human populations. In: Singh CF, Hanis CL (eds) Impact of genetic variation on individuals, families, and populations. Oxford University Press, OxfordGoogle Scholar
  10. 10.
    Nei M (1972) Genetic distance between populations. Am Naturalist 106: 283–292CrossRefGoogle Scholar
  11. 11.
    Nei M (1987) Molecular evolutionary genetics. Columbia University Press, New YorkGoogle Scholar
  12. 12.
    Nei M, Tajima F, Tateno Y (1983) Accuracy of estimated phylogenetic trees from molecular data. II. Gene frequency data. J Mol Evol 19: 153–170PubMedCrossRefGoogle Scholar
  13. 13.
    Livshits G, Nei M (1990) Relationships between intrapopulational and interpopulational genetic diversity in man. Ann Hum Biol 17: 501–513PubMedCrossRefGoogle Scholar
  14. 14.
    Saitou N, Nei M (1987) The neighbor-joining method: A new method for reconstructing phylogenetic trees. Mol Biol Evol 4: 406–425PubMedGoogle Scholar
  15. 15.
    Omoto K (1972) Polymorphisms and genetic affinities of the Ainu of Hokkaido. Hum Biol Oceania 1: 278–288PubMedGoogle Scholar
  16. 16.
    Lewin R (1988) In the age of mankind. Smithsonian Institution, WashingtonGoogle Scholar
  17. 17.
    Coon CS (1962) The origin of races. Knopf, New YorkGoogle Scholar
  18. 18.
    Coon CS (1965) The living races of man. Knopf, New YorkGoogle Scholar
  19. 19.
    Weiss KM, Maruyama T (1976) Archaeology, population genetics, and studies of human racial ancestry. Am J Phys Anthropol 44: 31 — 50PubMedCrossRefGoogle Scholar
  20. 20.
    Wolpoff MH, Wu X, Thorne AG (1984) Modern Homo sapiens origins: A general theory of hominid evolution involving the fossil evidence from east Asia. In: Smith FH, Spencer F (eds) The origin of modern humans. Alan R. Liss, New York, pp 411–483Google Scholar
  21. 21.
    Stringer CB, Andrews P (1988) Genetic and fossil evidence for the origin of modern humans. Science 239: 1263–1268PubMedCrossRefGoogle Scholar
  22. 22.
    Andrews P (1986) Fossil evidence on human origins and dispersal. Cold Spring Harb Symp Quant Biol 51: 419–428PubMedGoogle Scholar
  23. 23.
    Valladas H, Reyss JL, Joron JL, Valladas G, Bar-YosefO, Vandermeersch B (1988) Thermoluminescence dating of Mousterian ‘Proto-Cro-Magnon’ remains from Israel and the origin of modern man. Nature 331: 614–616CrossRefGoogle Scholar
  24. 24.
    Flint RF (1976) Pleistocene epoch. Encyclopaedia Britannica 14: 558–569Google Scholar
  25. 25.
    Cann RL, Stoneking M, Wilson AC (1987) Mitochondrial DNA and human evolution. Nature 325: 31–36PubMedCrossRefGoogle Scholar
  26. 26.
    Nei M (1985) Human evolution at the molecular level. In: Ohta T, Aoki K (eds) Population genetics and molecular evolution. Japan Scientific Societies, Tokyo, pp 41– 64Google Scholar
  27. 27.
    Kingman JFC (1982) On the genealogy of large populations. J Appl Probab 19A: 27–43CrossRefGoogle Scholar
  28. 28.
    Tajima F (1983) Evolutionary relationships of DNA sequences in finite populations. Genetics 105: 437–460PubMedGoogle Scholar
  29. 29.
    Nei M, Graur D (1984) Extent of protein polymorphism and the neutral mutation theory. Evol Biol 17: 73–118Google Scholar
  30. 30.
    Wright S (1943) Isolation by distance. Genetics 28: 114–138PubMedGoogle Scholar
  31. 31.
    Mayr E (1963) Animal species and evolution. Harvard University Press, CambridgeGoogle Scholar
  32. 32.
    Bahn (1987) Excavation of a palaeolithic plank from Japan. Nature 329: 110CrossRefGoogle Scholar
  33. 33.
    Omoto K (1981) The genetic origins of the Philippine Negritos. Curr Anthrop 22:421– 422CrossRefGoogle Scholar
  34. 34.
    Bray (1986) Finding the earliest Americans. Nature 321: 726CrossRefGoogle Scholar
  35. 35.
    Dillerhag TD, Collins MB (1988) Early cultural evidence from Monte Verde in Chile. Nature 332: 150–152CrossRefGoogle Scholar
  36. 36.
    Brooks AS, Wood B (1990) Paleoanthropology: The Chinese side of the story. Nature 344: 288–289PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Masatoshi Nei
    • 1
  • Tatsuya Ota
    • 1
  1. 1.Institute of Molecular Evolutionary GeneticsPenn State UniversityUniversity ParkUSA

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