Epidemiological Aspects of Intestinal Anisakiasis and Its Pathogenesis

  • H. Ishikura


Nationwide surveys of anisakiasis in Japan have been compiled are mainly evaluations of cases with eosinophilic granuloma from pathological labaratories at various universities [1,2,6]. Since 1955 Ishikura has kept a record of acute localized enteritis, and in 1965 determined the need for a separate pathological entity for the majority of such cases [10]. They were evaluated as intestinal anisakiasis, and show that this disorder is common in the north, with the chronic granuloma and phlegmonous acute intestinal type especially common, since many of the marine organisms that act as paratenic hosts are caught in large volumes in that area. Diagnosis of the acute form of intestinal anisakiasis has been increasing rapidly, beginning with the use of the endoscope to establish the presence of larvae in cases of peritonitis displaying acute symptoms [11].


Epidemiological Aspect Chub Mackerel Serous Membrane Fulminant Type Scomber Japonicus 
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  1. 1.
    Yokogawa M, Yoshimura H (1965) Anisakis-like larvae causing eosinophilic granulomata in the stomach of man. Am J Trop Med Hyg 14: 770–773PubMedGoogle Scholar
  2. 2.
    Yoshimura H (1966) Clinicopathological analysis on Anisakis-like larva infection in the digestive apparatus of man. Jpn J Parasitol 15: 283–284 (in Japanese)Google Scholar
  3. 3.
    Yoshimura H (1966) Clinic of parasitic gramuloma of human digestive tract and its entity. Stomach Intestine 1: 803–811 (in Japanese)Google Scholar
  4. 4.
    Yoshimura H (1966) A case of acute abdomen due to provable penetration of Anisakis-like larva into the intestinal wall. Surgical Treatment 15: 626–630 (in Japanese)Google Scholar
  5. 5.
    Ishikura H, Kikuchi Y, Hayasaka H, Miyagi H, Ueno T (1968) Anisakiasis in Hokkaido. Jpn J Clin Surg Soc 29: 49–60 (in Japanese)Google Scholar
  6. 6.
    Ishikura H (1969) Occurrence of anisakiasis and its presentation Saishin Igaku 24: 357–365 (in Japanese)Google Scholar
  7. 7.
    Iwano H, Ishikura H, Hayasaka H (1974) Statistical analysis of anisakiasis in Japan during the last five years. Geka Shinryo 16: 1336–1342 (in Japanese)Google Scholar
  8. 8.
    Koyama T, Araki J, Machida M, Karasawa Y (1982) Current problems on the anisakiasis. Modern Media 9: 434–443 (in Japanese)Google Scholar
  9. 9.
    Ishikura H, Kikuchi Y, Ishikura H (1983) Enteritis acuta caused by Anisakis larvae (Intestinal anisakiasis). Stomach and Intestine 18: 293–297 (in Japanese)Google Scholar
  10. 10.
    Ishikura H (1965) Feature of regional enteritis which frequently occurred at Iwanai district-proposal of the pathological entity. Hokkaido J Surg 10: 29–38 (in Japanese)Google Scholar
  11. 11.
    Namiki M, Morooka T, Kawauchi H, Ueda N, Sekiya C, Nakagawa K, Furuta T, Ooguro T, Kamada H (1970) Diagnosis of acute gastric anisakiasis. Stomach and Intestine 5: 1437–1440 (in Japanese)Google Scholar
  12. 12.
    Ishikura H (1985) Anisakiasis, Review of the literature. (suppl) 6: 1–40. Sapporo, (printed privately, in Japanese)Google Scholar
  13. 13.
    Asaishi K, Nishino C, Totsuka M, Hayasaka H, Suzuki T (1980) Studies on the etiologic mechanism on anisakiasis-2 Epidemiological study of inhabitants and questionnaire survey in Japan. Jpn Soc Gastroenterol 15: 128–134Google Scholar
  14. 14.
    Karasawa Y, Kawakami Y, Hirafuku I, Hoshi K, Koyama T (1983) Studies on anisakiasis and terranovasis of the digestive tract. Jpn Med J 3099: 30–34 (in Japanese)Google Scholar
  15. 15.
    Iino H (1985) Occurrence of Anisakiasis in Kyushu (6th examination). Jpn J Gastroenterol Endosc 27: 630 (in Japanese)Google Scholar
  16. 16.
    Totzuka M (1974) II Human anisakiasis 3. Epidemiology: Fishes and Anisakis (No.7 fishes scientific series). The Japanese Society of Scientific Fisheries, Koseisha Koseikaku, Tokyo, pp. 44–57 (in Japanese)Google Scholar
  17. 17.
    Hitchcock DJ (1950) Parasitological study on the Eskimos in the Bethel area of Alaska. J Parasit 36: 23–234CrossRefGoogle Scholar
  18. 18.
    van Thiel PH, van Kuipers FC, Roskam RTh (1960) A nematode parasitic to herring causing acute abdominal syndromes in man. Trop Geogr Med 12: 97–115PubMedGoogle Scholar
  19. 19.
    Ruitenberg EJ (1970) Anisakiasis. Pathogenesis, serodiagnosis and prevention; Doctor thesis in Rijks University, Utrecht. (Translation into Japanese by Ooishi K et al.)Google Scholar
  20. 20.
    Myers BJ (1963) The migration of Anisakis-type larvae in experimental animals. Canad J Zoo1 45: 147–148 (1963)CrossRefGoogle Scholar
  21. 21.
    Young PC (1969) Larval nemotodes from fish of the subfamily Anisakinae and gastro-intestinallesions in mammals. J Comp Path 79: 301–313PubMedCrossRefGoogle Scholar
  22. 22.
    Usutani T (1966) Histological studies on experimental animals administered with Anisakis-like larvae from marine fish (Studies on larva migrans, Part 3). Shikoku Acta Med 22: 486–503 (in Japanese)Google Scholar
  23. 23.
    Oyanagi T (1967) Experimental studies on the visceral migrans of gastro-intestinal walls due to Anisakis larvae. Jpn J Parasitol 16: 470–493 (in Japanese)Google Scholar
  24. 24.
    Okumura T (1967) Experimental studies on the anisakiasis. J Osaka City Med Center 16: 465–499 (in Japanese)Google Scholar
  25. 25.
    Matsuoka Y (1966) Studies on peripheral blood picture and serum protein in experimental anisakiasis (Studies on larva migrans Part 4). Shikoku Acta Med 22: 12- 36 (in Japanese)Google Scholar
  26. 26.
    Ishikura H, Hayasaka H, Miyagi H, Ueno T, Uchiumi A, Saeki H (1968) Studies on anisakiasis (7) Allergic reaction by oral administration of frozen Anisakis larvae in rabbits, Jpn J Parasitol 17: 266 (in Japanese)Google Scholar
  27. 27.
    Suzuki T, Shiraki T, Sekino S, Otsuru M, Ishikura H (1970) Studies on the immunological diagnosis of anisakiasis. III Intradermal test with purified antigen. Jpn J Parasitol 19: 1–9 (in Japanese)Google Scholar
  28. 28.
    Inamoto T (1972) Experimental Studies on the Tissue Invasion and Ecdysis of Anisakis Larvae. J Osaka City Med Center 21: 243–269 (in Japanese)Google Scholar
  29. 29.
    Yoshimura H, Kondo K, Akao N, Onishi Y, Watanabe K, Shinno T, Akikawa K (1979) Two cases of eosinophlic granulomas formed in the large omentum and mesentery by the penetrated Anisakis larva through the gastrointestinal tract. Stomach and Intestine 14: 519–522 (in Japanese)Google Scholar
  30. 30.
    Ishikura H (1981) Anisakiasis, Review of the literature. (suppl) 4: 1–16. Sapporo, (printed privately, in Japanese)Google Scholar
  31. 31.
    Suzuki T, Ishikura H (1974) Pathogenic mechanisms, symptoms and diagrams of anasakiasis. Fishes and Anisakis (No.7 fishes scientific series). The Japanese Society of Scientific Fisheries, Koseisha Koseikaku, Tokyo, pp. 58–72 (in Japanese)Google Scholar
  32. 32.
    Mizugaki H, Asaishi K, Ishikura H, Hayasaka H (1970) Studies on enteritis regionatis (VI)-Experimental study on skip lesion. Hokkaido J Surg 15: 47–52 (in Japanese)Google Scholar
  33. 33.
    Ishikura H, Mizugaki H, Hayasaka H (1971) Studies on regional enteritis (7)Experimental studies on enteritis regionalis exsudativa acuta with bacillus infection. Hokkaido J Med Sci 46: 374–381 (in Japanese)Google Scholar
  34. 34.
    Ishikura H, Kikuchi Y, Hayasaka H (1967) Pathological and clinical observation on intestinal anisakiasis. Arch Jpn Chir 36: 663–679 (in Japanese)Google Scholar
  35. 35.
    Fukuda S, Hachisuga K, Yamaguchi A et at. (1984) Three cases of anisakiasis causing acute intestinal obstruction. Clin Surg 39: 707–711 (in Japanese)Google Scholar
  36. 36.
    Sasaki M, Aoki Y, Syoji M, Matsumoto K, Okamoto S, Katsumi M (1979) A case report of perforation of small intestine by penetrated Anisakis larva, Jpn J Surg 80: 288 (in Japanese)Google Scholar
  37. 37.
    Kikuchi Y, Ueda T, Yoshiki T, Aizawa M, Ishikura H (1967) Experimental immunopathological studies on intestinal anisakiasis. Igakuno Ayumi 62 (11): 731–736 (in Japanese)Google Scholar
  38. 38.
    Kuipers FC, Kampelmacher EH, Steenbergen F (1963) Onderzoekingen over harinawormziekte dij Konijen. Ned T Geneesk 22: 990–995Google Scholar
  39. 39.
    Ishikura H, Kanemoto T, Goto T, (1960) Acute abdomen caused by ileitis terminalis: A case accompanied skip areas and invaginations ileus. Jpn J Gastroenterol 58: 867 (in Japanese)Google Scholar
  40. 40.
    Ishikura H, Tanaka M, Goto T et at. (1965) Studies on regional enteritis: I. Epidemiology of 87 cases at Iwanai district in Hokkaido. Geka chiryo 13: 144–154 (in Japanese)Google Scholar
  41. 41.
    Ishikura H. Kikuchi K, Tsuji Y (1961) Several clinico-pathological appearances on Crohn’s disease. J Clin Digestive Disease 3: 662–675 (in Japanese)Google Scholar
  42. 42.
    Inoue J, Shimizu N, Yoshida K, Fugii S, Adachi H (1974) Clinical studies on 6 cases of intestinal anisakiasis, particularly cases accompanied by skip lesion. Clin Surg 29: 809–814 (in Japanese)Google Scholar
  43. 43.
    Sasaki K, Sasaki T, Nagamine Y (1984) A case report of intestinal anisakiasis with skip lesion and mesenteric granulima formation. J Jpn Soc Clin Surg 45: 1183–1187 (in Japanese)Google Scholar
  44. 44.
    Ishikura H, Mizugaki H, Asaishi K, Sato K, Hayasaka H (1970) Studies on enteritis regionalis (4)-Histo-pathological studies on regional enteritis acuta in Japan. J Jpn Soc Clin Surg 31: 79–91 (in Japanese)Google Scholar
  45. 45.
    Saito K, Okino M (1966): Enteritis regionalis; Clin & Ex Med 43: 1818–1823 (in Japanese)Google Scholar
  46. 46.
    Naka T, Aikawa K, Shinno T, Kuranishi H (1969) Experiences with acute nonspecific regional enteritis. Clin Surg 24: 129–133 (in Japanese)Google Scholar
  47. 47.
    Ishikura H, Mizugaki H, Hayasaka H (1971) Studies on regional enteritis (7)Experimental studies on enteritis regionalis exsudative acuta with bacillus infection. Hokkaido J Med Sci 46: 374–381 (in Japanese)Google Scholar
  48. 48.
    Furukawa A (1974) Anisakiasis-Its history and a case of acute ileitis, attributable to a living larva of Anisakis in a peritoneal cavity. J Jpn Soc Clin Surg 35: 63–69 (in Japanese)Google Scholar
  49. 49.
    Yoshimura H, Kondo K, Oonishi Y, Akao N, Tsubota N (1978) Statistical observation on Anisakiasis of our department during the last 3 years, especially on its clinicopathology and immunodiagnostics. Jpn Med J 2837: 29–32 (in Japanese)Google Scholar
  50. 50.
    Ishikura H, Kobayashi Y, Yagi K, Fujita O, Nakajima O, Miyamoto K,(1987) Current topics of terranovasis in Japan Proceedings of the 34th North Japan regional meeting 39pp. in Sapporo City, Hokkaido, Sept 11 (in Japanese)Google Scholar
  51. 51.
    Karasawa Y, Takahara K, Hirafuku I, Hoshi K (1984) Experience of anisakiasis and terranovasis of digestive tracts. Gastroenterol Endose 26: 2134–2135 (in Japanese)Google Scholar
  52. 52.
    Suzuki H, Oonuma H, Karasawa Y (1972) Terranova larva infection in human stomach wall. Saishin Igaku 29: 521–526 (in Japanese)Google Scholar
  53. 53.
    Nishimura T (1969) Ecological appearance on Anisakis larvae. Sai-shin Igaku 24: 405–412 (in Japanese)Google Scholar
  54. 54.
    Ishikura H, Hayasaka H (1974) Current problems on anisakiasis in Japan. Surg 36: 887–892 (in Japanese)Google Scholar
  55. 55.
    Ishikura H (1969) Anisakiasis, especially treatment of intestinal anisakiasis. Jpn Med J 2375: 133 (in Japanese)Google Scholar
  56. 56.
    Hara K, Yokoyama T (1985) A clinical study on possible anisakiasis intestinalis causing acute intestinal obstruction. J Jpn Soc Clin Surg 46: 416–421 (in Japanese)Google Scholar
  57. 57.
    Desowitz RS: Human and experimental anisakiasis in the United States (1986) Hokkaido J Med Sci 61: 358–371PubMedGoogle Scholar
  58. 58.
    Kagei N, Yanagawa I, Nagano K, Oishi K (1972) A larva of Terranova sp. Causing acute abdominal syndrome in woman. Jpn J Parasitol 21: 262–265Google Scholar
  59. 59.
    Ishikura H (1989) New findings concerning Anisakis larva and anisakiasis. Jpn Soc Clin Surg 50: 237–247 (in Japanese with English abstract)Google Scholar
  60. 60.
    Ishikura H. Namiki M (Eds) (1989) Gastric anisakiasis in Japan-Epidemiology, Diagnosis, Treatment. Springer-Verlag Tokyo 140pp.Google Scholar
  61. 61.
    Hayasaka H, Takagi R, Iwano H, Asaishi K, Ishikura H, Mizugaki H (1969) A case of anisakiasis causeq by two Anisakis larvae penetration. Hokkaido J Med Sci 14: 141–146 (in Japanese with English abstract)Google Scholar

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© Springer-Verlag Tokyo 1990

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  • H. Ishikura

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