Clinical Patho-Parasitology of Extra-Gastrointestinal Anisakiasis

  • H. Yoshimura


Previous investigations have demonstrated that Anisakis larva orally administered to experimental animals can easily penetrate through the gastrointestinal tract and reach the abdominal cavity a few days after ingestion of the larva [1-4]. Since the first case of extra-gastrointestinal anisakiasis was reported in Holland [5], 16 other cases have been documented in other countries, though the majority were from Japan [6-15] (Table 1). The locations of Anisakis larvae in the tissues were abdominal cavity (3), large omentum or mesentery (6), subcutaneous tissues (4), pleural cavity (1) and others (3). All except three cases, harbored a larva in the involved tissues, and five patients were examined pathoparasitologic ally by means of immunodiagnoses (Table 1).


Abdominal Cavity Bluefin Tuna Intestinal Perforation Latex Agglutination Radioallergosorbent Test 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Yoshimura H (1966) Migration of Anisakis-like larva, causing eosinophilic granuloma in the alimentary tract of man. Minophagen Med Review 11: 105–114 (in Japanese)Google Scholar
  2. 2.
    Asami K, Inoshita Y (1967) Experimental anisakiasis in guinea pigs; Factors influencing infection of larvae in the host. Jpn J Parasitol 16: 415–422Google Scholar
  3. 3.
    Oyanagi T (1967) Experimental studies on the visceral migrans of gastrointestinal walls due to Anisakis larvae. Jpn J Parasitol 16: 470–493 (in Japanese with English abstract)Google Scholar
  4. 4.
    Ruitenberg EJ (1970) Anisakiasis: Pathogenesis, serodiagnosis and prevention PhD thesis, Rijks University, Utrecht, pp. 33–45Google Scholar
  5. 5.
    Van Thiel PH, Van Houten H (1967) The localization of the herringworm Anisakis marina in and outside, the human gastrointestinal wall. Trop Geogr Med 19: 56–62PubMedGoogle Scholar
  6. 6.
    Yoshimura H, Akao N, Kondo K, Ohnishi Y, Funaoka Y, Yamane K (1980) Two cases of extra-gastrointestinal infection with Anisakis larvae and their immunodiagnoses. Jpn J Clinical Pathol 28: 708–712 (in Japanese)Google Scholar
  7. 7.
    Furukawa A (1974) Anisakiasis, its history and a case of acute ileitis, attributable to a living larva of Anisakis in the peritoneal cavity. J Jpn Soc Clin Surgery 35: 63–69 (in Japanese)Google Scholar
  8. 8.
    Nishimura T, Tanaka E, Ito Y, Sugihara Y, Morishita K, Watanabe S, Watanabe S (1974) Report of three cases of human anisakiasis: Larvae, each recovered from the different organs of men, and their morphological studies. J Hyogo College of Med 2: 124–139 (in Japanese with English abstract)Google Scholar
  9. 9.
    Sasaki S, Aoki Y, Shoji M Matsumoto K, Okamura S, Katsumi M (1978) A case of the intestinal perforation due to Anisakis larva. J Jpn Soc Clin Surg 39: 61–65 (in Japanese)Google Scholar
  10. 10.
    Kagei N, Sakaguchi Y (1977) Interesting cases due to Anisakis larva. Nihon Igi Shinpo 2786: 32–34 (in Japanese)Google Scholar
  11. 11.
    Matsuki N, Ariga T, Tsuchihara K, Furukawa N, Kozaka S (1979) A case of abdominal wall mass due to anisakiasis. J Clin Surgery 34: 1169–1171 (in Japanese)Google Scholar
  12. 12.
    Yoshimura H, Kondo K, Akao N, Ohnishi Y, Watanabe K, Shinno B, Aikawa K (1979) Two cases of eosinophilic granulomas formed in the large omentum and mesentery by the penetrated Anisakis larva through the gastrointestinal tract. Stomach and Intestine 14: 519–522 (in Japanese with English abstract)Google Scholar
  13. 13.
    Yoshimura H, Akao N, Kondo K, Ohnishi Y (1979) Clinicopathological studies on larval anisakiasis, with special reference to the report of extra-gastrointestinal anisakiasis. Jpn J Parasitol 28: 347–354Google Scholar
  14. 14.
    Yoshimura H, Akao N, Kondo K, Ohnishi Y (1980) Two cases of subcutaneous involvement due toAnisakis larva. Jpn J Parasitol 29 (Suppl): 52 (in Japanese)Google Scholar
  15. 15.
    Momma N, Iwasaki T, Satodate R, Ito I (1985) Three cases of parasitic granulomas due to Anisakis parasitic in the lymph node, large omentum and parietal subperitoneal tissues. Iwate Med J 37: 919 (in Japanese)Google Scholar
  16. 16.
    Kobayashi A, Tsuji M, Wilbur D (1985) Probable pulmonary anisakiasis accompanying pleural effusion. Am J Trop Med Hyg 34: 310–313PubMedGoogle Scholar
  17. 17.
    Codeau P, Danis M, Bouchareine A, Nozais J (1986) An unusual case of aedema: Anisakis. Helminthol Abstract 55: 297–298Google Scholar
  18. 18.
    Yoshimura H, Kaneda J, Suzuki T, Takaso T, Mikoshiba Y (1966) A case of acute abdomen due to probable penetration of Anisakis-like larva into intestinal wall. Surgical Treat 15: 626–630 (in Japanese)Google Scholar
  19. 19.
    Yokogawa M, Yoshimura H (1967) Clinicopathological studies on larval anisakiasis in Japan. Am J Trop Med Hyg 16: 723–728PubMedGoogle Scholar
  20. 20.
    Ishikura H, Kikuchi Y, Hayasaka H (1967) Pathological and clinical observation on intestinal anisakiasis. Arch Jpn Chir 36: 663–679 (in Japanese with English abstract)Google Scholar
  21. 21.
    Maruyama A, Inaba, Aiuchi Y, Suzuki S, Fujita T (1981) Two cases of intestinal anisakiasis-Skip lesion and perforation. Surgical Diag and Treat 23: 517–523 (in Japanese)Google Scholar
  22. 22.
    Sasaki K, Kamita N, Yamaguchi Y (1982) Four cases of anisakiasis, especially a case of intestinal perforation cause by Anisakis larvae. J Jpn Soc Clin Surg 43: 1374–1380 (in Japanese)Google Scholar
  23. 23.
    Tsukamoto H, Koizumi W, Atari E, Okudaira M, Yoshizawa S, Maekawa K, Mieno H, Hamashima H, Ishikawa J, Takahashi T, Hiki Y, Aso K (1987) A case of gastric anisakiasis, causing gastric perforation. Jpn J Gastroenterol 84: 104–107 (in Japanese)Google Scholar
  24. 24.
    Desowitz RS, Raybourne RB, Ishikura H, Kliks MM (1985) The radioallergosorbent test (RAST) for the serological diagnosis of human anisakiasis. Transact Roy Soc Trop Med Hyg 79: 256–259CrossRefGoogle Scholar
  25. 25.
    Yoshimura H, Kondo K, Ohnishi Y, Akao N, Tsubota N (1978) Summary of human anisakiasis during past three years in our laboratory-with special reference to clinicopathology and immunodiagnoses. Nihon Igi Shinpo 2837: 29–32 (in Japanese)Google Scholar
  26. 26.
    Kobayashi A, Kumada M, Ishizaki T, Suguro T, Koito K (1968) Skin tests with somatic and ES (excretions and secretions) antigens from Anisakis larvae. II. The difference of antigenicity between the two antigens. Jpn J Parasitol 17: 414–418 (in Japanese with English abstract)Google Scholar
  27. 27.
    Suzuki T, Shiraki T, Sekino T, Otsuru M, Ishikura H (1970) Studies on the immunological diagnosis of anisakiasis. III. Intradermal test with purified antigen. Jpn J Parasitol 19: 1–9 (in Japanese with English abstract)Google Scholar
  28. 28.
    Suzuki T, Ishida K, Asaishi K, Nishino C (1976) Studies on the immunodiagnosis of anisakiasis. 6. Analysis of criteria on intradermai and indirect hemagglutination tests by means ofradioimmunoassay. Jpn J Parasitol 25: 17–23 (in Japanese with English abstract)Google Scholar

Copyright information

© Springer-Verlag Tokyo 1990

Authors and Affiliations

  • H. Yoshimura

There are no affiliations available

Personalised recommendations