A History of Research into Gastric Anisakiasis in Japan

  • M. Namiki


Progress in research into gastric anisakiasis in Japan has developed more slowly than research into intestinal anisakiasis. Remarkable and rapid progress, however, has been achieved since 1968 when endoscopic examination allowed the observation of Anisakis larvae penetrating the gastric wall and removal and direct identification of the worm. Previously, gastric anisakiasis could only be diagnosed when dead worms and/or their cross sections were histopathologically observed inside granulomas with eosinophilic cell infiltration in the resected stomach. Although the presence of granulomas with eosinophilic cell infiltration in the stomach had been known since the 1950s, Asami et al. [1] confirmed the relation between them and the infection of Anisakis larvae in 1964. Their work resulted in the establishment by the Ministry of Education of a research group in 1965 concerned with parasitic granulomas, which was headed by Ohtsuru. In addition, many cases of granulomas with eosinophilic cell infiltration caused by Anisakis larvae in the stomach have been reported since 1967. However, it roved difficult to confirm gastric anisakiasis by the conventional method of endoscopie biopsy because the granulomas were too small. This was also found to be the case when granulomas were biopsied with the endoscopie incision method for the submucosal tumors using an electric high-frequency wave. Therefore, the most reliable method seemed to involve obtaining large tissue specimens by jumbo-biopsy.


Gastric Wall Endoscopic Examination Submucosal Tumor Stomach Intestine Fulminant Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Asami K, Watanuki T, Sakai H, Imano H, Okamoto R (1964) Two cases of stomach granuloma caused by anisakis-like larvae nematodes in Japan. Am J Trop Med Hyg 14: 119–123Google Scholar
  2. 2.
    Namiki M, Morooka T, Kawauchi H, Ueda N, Sekiya C, Nakagawa K, Furuta T, Oguro T, Kamata H (1970) Diagnosis of acute gastric anisakiasis. Stomach Intestine 5: 1437–1440 (in Japanese)Google Scholar
  3. 3.
    Suzuki H, Ohnuma H, Karasawa Y, Ohbayashi M, Koyama T, Kumada M, Yokogawa M (1972) Terranova (Nematoda: Anisakidae) infection in man: I. Clinical features of five cases of terranova larva infection. Jpn J Parasit 21: 252–256 (in Japanese)Google Scholar
  4. 4.
    Nagano K, Takagi K, Yanagawa I, Oishi K, Kagei N (1973) Acute hetero-cheilidasis of the stomach (due to Terranova decipiens). Stomach Intestine 8: 81–85 (in Japanese)Google Scholar
  5. 5.
    Kagei N, Yamakawa I, Nagano K, Oishi K (1972) A larva of terranova causing acute abdominal syndrome in a woman. Jpn J Parasit 21: 262–265 (in Japanese)Google Scholar
  6. 6.
    Doi K (1973) Clinical aspects of acute heterocheilidasis of the stomach (due to larvae of anisakis and terranova-decipiens)—Especially on its differential diagnosis by X-ray and endoscopy. Stomach Intestine 8: 1513–1518 (in Japanese)Google Scholar
  7. 7.
    Suzuki T, Ishikura H (1974) Pathogenic mechanisms, symptoms and diagnosis of anisakiasis. Fishes and Anisakis (no. 7 Fisheries scientific series). Japanese Society of Scientific Fisheries. Kohseisha Kohseikaku, Tokyo, pp 58–72 (in Japanese)Google Scholar
  8. 8.
    Suzuki T (1978) Anisakis and Terranova larva, and Anisakiasis. In: Otsuru M (ed) Clinical parasitology. Nankodo, Tokyo, pp 300–308 (in Japanese)Google Scholar
  9. 9.
    Kawauchi H, Namiki M, Morooka T, Nakagawa K, Oguro T (1973) Gastric anisakiasis presenting acute gastrointestinal symptoms—with special references to the endoscopic and roentgenographic findings of anisakis larva penetrating into the wall of the human stomach and to its clinical features. Stomach Intestine 8: 31–38 (in Japanese)Google Scholar
  10. 10.
    Nakata H, Takeda K, Nakayama T (1980) Radiological diagnosis of acute gastric anisakiasis. Radiology 135: 49–53PubMedGoogle Scholar
  11. 11.
    Sugimachi K, Inokuchi K, Oiwa T, Fujino T, Ishii Y (1985) Acute gastric anisakiasis—analysis of 178 cases. JAMA 253: 1012–1013PubMedCrossRefGoogle Scholar
  12. 12.
    Hirota K, Uchida Y, Hatano Y, Yasutake R, Okazaki Y, Takemoto T, Fujii Y, Iwata T (1986) A case of gastric anisakiasis taking the course of vanishing tumor of the stomach. Gastroenterol Endosc 28: 780–794 (in Japanese)Google Scholar
  13. 13.
    Yamasaki M (1976) Vanishing tumor of the stomach? Jpn J Clin Radiol 21: 47–54 (in Japanese)Google Scholar
  14. 14.
    Muraoka H, Suzuki S, Okuaki K, Kimura K (1984) A case of “Vanishing tumor of the stomach” due to parasitosis. Gastroenterol Endosc 26: 1719–1724 (in Japanese)Google Scholar
  15. 15.
    Mikami Y (1983) The submucosal tumor due to anisakis larva at the fornix of the stomach. Shimane Med 6: 871–877 (in Japanese)Google Scholar
  16. 16.
    Sakai T, Arima N, Sakemi Y, Majima Y, Toyonaga A, Tanikawa H (1986) Ultra-sonographic evaluation of gastric anisakiasis. Jpn J Clin Radiol 31: 949–952 (in Japanese)Google Scholar
  17. 17.
    Hasegawa N, Yoshida S, Yamaguchi H, Tajiri H, Saito O, Hijikata A, Ibe A, Egawa K, Nojiri O, Yoshimori M, Oguro Y, Itabashi M, Hirota T (1984) Usefulness of the simple contrast techinic in endoscopic diagnosis of neoplastic lesions in the stomach. Prog Digest Endosc 25: 113–117 (in Japanese)Google Scholar
  18. 18.
    Hoshihara Y, Yamamoto T, Koyama M, Kawahara H, Kawaguchi Y, Watanabe K (1984) A case of gastric anisakiasis without acute gastrointestinal symptoms, unexpectedly found by contrast dye-method on the endoscopie examination. Prog Digest Endosc 25: 223–225 (in Japanese)Google Scholar
  19. 19.
    Ishikura H (1984) Anisakiasis. Supplement No. 5 (’82–’83). In: Ishikura H (ed) Ishi-kura hospital. Iwanai, p 7 (in Japanese)Google Scholar
  20. 20.
    Lino H (1984) Anisakiasis in Kyushu. Gastroenterol Endosc 26: 2135 (in Japanese)Google Scholar
  21. 21.
    Matsushita F, Sakaguchi K, Arima T, Kamikozuru K, Nagai T, Shibue T, Yamashita Y, Hashimoto S (1984) Analysis of 326 cases of anisakiasis occurred at northwest Kagoshima. Gastroenterol Endosc 26: 2135 (In Japanese)Google Scholar
  22. 22.
    Fujino T, Oiwa T, Ishii Y (1984) Clinical, epidemiological and morphological studies on 150 case of acute gastric anisakiasis in Fukuoka prefecture. Jpn J Parasitol 33: 73–92 (in Japanese)Google Scholar
  23. 23.
    Omachi K, Omachi T, Maruyama Y (1985) Anisakiasis of gastrointestinal tract in Nagano prefecture. Shinshu Med J 33: 42–56 (in Japanese)Google Scholar
  24. 24.
    Kagei N, Sano M, Takahashi Y, Tamura Y, Sakamoto M (1978) A case of acute abdominal symptome caused by anisakis type-2 larva. Jpn J Parasitol 27: 427–431 (in Japanese)Google Scholar
  25. 25.
    Saito M, Nozaki K, Suzuki S, Ishizaki T (1978) Terranovasis caused by terranova larva type B; a case report. Gastroenterol Endosc 20: 61 (in Japanese)Google Scholar
  26. 26.
    Kanemitsu K, Takara M, Torigoe Y, Satoh Y (1984) A case of anisakiasis in Okinawa. Saishin Igaku 39: 138–141 (in Japanese)Google Scholar
  27. 27.
    Ishikura H (1978) Anisakiasis. Hokkai Times, Sapporo (in Japanese)Google Scholar
  28. 28.
    Nishino C (1977) Epidemiological studies on anisakiasis. Sapporo Med J 46: 73–88 (in Japanese)Google Scholar
  29. 29.
    Suzuki T, Shiraki T, Otsuru M (1969) Studies on the immunological diagnosis of anisakiasis: II. Isolation and purification of anisakis antigen. Jpn J Parasitol 18: 232–240 (in Japanese)Google Scholar
  30. 30.
    Suzuki T, Otsuru M, Ishikura H (1970) Studies on the immunological diagnosis of anisakiasis: III. Intradermal test with purified antigen. Jpn J Parasitol 19: 1–9 (in Japanese)Google Scholar
  31. 31.
    Suzuki T, Ishida K, Asaishi K, Nishino C (1976) Studies on the immunological diagnosis: VI. Analysis of criteria on intradermal and indirect hemagglutination tests by means of radioimmunoassay. Jpn J Parasitol 25: 17–23 (in Japanese)Google Scholar
  32. 32.
    Takahashi S, Sato N, Sato T, Takami T, Mukaiya M, Yagihashi A, Tsurushiin M, Hayasaka H, Kikuchi K (1986) Detection of antianisakis larva antibodies using micro ELISA method. Igakuno Ayumi 136: 681–682 (in Japanese)Google Scholar
  33. 33.
    Takahashi S, Hayasaka H, Ishikura H, Koshida H, Kikuchi K (1985) Attempts to generate monoclonal antibodies against anisakis larvae. Anisakis, supplement No. 6’ 84–’85). In: Ishikura H (ed) Ishikura hospital, Iwanai, 7 (in Japanese)Google Scholar
  34. 34.
    Yokoya H, Ohe K, Miyoshi A, Hidaka T, Murakami Y, Tsuji M (1980) A study on the diagnosis of three cases of anisakiasis by means of immunoserological techniques. Stomach Intestine 15: 1329–1335 (in Japanese)Google Scholar
  35. 35.
    Tachibana M, Yamamoto Y (1986) Serum anti-anisakis IgE antibody in patients with acute gastric anisakiasis. Jpn J Gastroenterol 83: 2132–2138 (in Japanese)Google Scholar

Copyright information

© Springer-Verlag Tokyo 1989

Authors and Affiliations

  • M. Namiki

There are no affiliations available

Personalised recommendations