Abstract
Control of cell proliferation involves a complex interplay between direct mechanisms linking a cell with adjacent cells and their interstitial stroma, and indirect mechanisms mediated through factors carried by organ vasculature. Disruption of the functional integrity of growth regulatory systems may lead to uncontrolled proliferation and abnormal cellular behaviour manifest in a most extreme form in the development of malignant tumours.
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References
Almendral JM, Sommer D, Macdonald-Bravo H, Burckhardt J, Perera J and Bravo R (1988) Complexity of the early genetic response to growth factors in mouse fibroblasts. Mol Cell Biol 8:2140–2148
Battegay EJ, Raines EW, Siefert RA, Bowen-Pope DF and Ross R (1990) TGFb induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop. Cell 63:515–524
Benbrook DM and Jones NC (1990) Heterodimer formation between CREB and JUN proteins. Oncogene 5:295–305
Berg JM (1989) DNA binding specificity of steroid receptors. Cell 57:1065–1068
Bos J (1989) ras oncogenes in human cancer: a review. Cancer Res 49:4682–4689
Bravo R (1990) Genes induced during the Go/Gj transition in mouse fibroblasts. Semin Cancer Biol 1:37–46
Burns CP and Rozengurt E (1984) Extracellular Na+ and initiation of DNA synthesis: role of intracellular pH and K+. J Cell Biol 98:1082–1089
Carpenter G (1987) Receptors for epidermal growth factor and other polypeptide mitogens. Annu Rev Biochem 56:81–91
Cho-Chung YS (1990) Role of cyclic AMP receptor proteins in growth, differentiation, and suppression of malignancy: new approaches to therapy. Cancer Res 50:7093–7100
Cole MD (1986) The myc oncogene: its role in transformation and differentiation. Annu Rev Genet 20:361–386
Cordingley MG, Riegel AT and Hager GL (1987) Steroid-dependent interaction of transcription factors with the inducible promoter of mouse mammary tumour virus in vitro. Cell 48:261–270
Curran T and Franza Jr BR (1988) Fos and Jun: the API connection. Cell 55:395–397
DeCaprio J A, Ludlow JW and Lynch D, et al. (1989) The product of the retinoblastoma gene has properties of a cell cycle regulatory element. Cell 58:1085–1095
Diamond MI, Miner JN, Yoshinaga SK and Yamamoto KR (1990) Transcription factor interactions: selectors of positive and negative regulation from a single DNA element. Science 249: 1266–1272
Diller L, Kassel J and Nelson CE, et al. (1990) p53 functions as a cell cycle control protein in osteosarcomas. Mol Cell Biol 11:5752–5781
Downward J, Graves JD, Warne PH, Rayter S and Cantrell DA (1990) Stimulation of p21ras upon T-cell activation. Nature 346:719–723
Dumont JE, Jauniaux JC and Roger PP (1989) The cyclic AMP-mediated stimulation of cell proliferation. TIBS 114:67–70
Edelman AM, Blumenthal DK and Krebs EG (1987) Protein serine/threonine kinases. Ann Rev Biochem 56:567–613
Eliyahu D, Michalovitch D and Oren M (1985) Overproduction of p53 antigen makes established cell highly tumorigenic. Nature 316:158–160
Evans G (1990) The myc oncogene. In: Carney D, Sikora K (eds) Genes and cancer. John Wiley amp Sons Ltd, Chichester, pp 31–43
Fearon ER and Vogelstein B (1990) A genetic model of colorectal carcinogenesis. Cell 61:759–767
Finlay CA, Hinds PW and Levine A J (1989) The p53 proto-oncogene can act as a suppressor of transformation. Cell 57:1083–1093
Fontana JA, Miranda D and Burrows-Mezu A (1990) Retinoic acid inhibition of human breast carcinoma proliferation is accompanied by inhibition of the synthesis of a Mr 39000 protein. Cancer Res 50:1977–1982
Gai X, Rizzo MG, Lee J, Ullrich A and Beserga R (1988) Abrogation of the requirements for added growth factors in 3T3 cells constitutively expressing the p53 and the IFF-1 genes. Oncogene Res 3:377–386
Gospodarowicz D, Neufield G and Schwiegerer L (1987) Fibroblast growth factor: structure and biological properties. J Cell Phys Suppl 5:15–26
Heldin CH and Westermark B (1989) Growth factors as transforming proteins. Eur J Biochem 184:487–496
Horowitz JM, Park SH and Bogenmann E, et al. (1990) Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumour cells. Proc Natl Acad Sci (USA) 87:2775–2779
Kaplan DR, Whitman D and Schaffhausen B, et al. (1987) Common elements in growth factor stimulation and oncogenic transformation: 85 kD phosphoprotein and phosphatidylinositol kinase activity. Cell 50:1021–1029
Karin M (1989) Complexities of gene regulation by cAMP. TIBS 5:65–67
Knabbe CME, Lippman ME and Wakefield LM, et al. (1987) Evidence that transforming factorbeta is a hormonally regulated negative growth factor in human breast cancer cells. Cell 48: 417–428
Kypta RM, Goldberg Y, Ulug ET and Courtneidge SA (1990) Association between the PDGF receptor and members of the src family of tyrosine kinases. Cell 62:481–492
Lamph WW, Wamsley P, Sassone-Corsi P and Vermi IM (1988) Induction of proto-oncogene JUN/AP1 by serum and TP A. Nature 334:629–634
Margolis B, Rhee SG and Felder S, et al. (1990) EGF induces phosphorylation of phospholipase C: a potential mechanism for EGF receptor signalling. Cell 57:1101–1107
Miesenhelder J, Suh PG, Rhee SG and Hunter T (1989) PhospholipaseC-y is a substrate for the PDGF and EGF receptor protein tyrosine kinases in vivo and in vitro. Cell 57:1109–1122
Molloy CJ, Bottaro DP, Fleming TP, Marshall MS, Gibbs JB and Aaronson S (1989) PDGF induction of tyrosine phosphorylation of GTPase activating protein. Nature 342:711–714
Moody TW, Pert CB, Gazdar AF, Carney DN and Minna JD (1981) High levels of intracellular bombesin characterize human small cell carcinoma cell lines. Science 214:1246
Morrison DK, Kaplan DR, Escobedo JA, Rapp UR, Roberts TM and Williams LT (1989) Direct activation of the serine-threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF B-receptor. Cell 58:649–657
Moses HL, Yang EY and Pietenpol JA (1990) TGF-β stimulation and inhibition of cell proliferation: new mechanistic insights. Cell 63:245–247
Muller R, Bravo R, Burckhardt J and Curran T (1984) Induction of c-fos gene and protein by growth factors precedes activation of c-myc. Nature 312:716–718
Nishizuka Y (1986) Studies and perspectives of protein kinase C. Science 233:305–311
Nishizuka Y (1988) The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature 334:661–668
Ong G, Sikora K and Gullick WJ (1991) Inactivation of the retinoblastoma gene does not lead to loss of TGFβ receptor or loss of response to TGFβ in breast cancer cell lines. Oncogene (in press)
Pardee AB (1989) G1 events and regulation of cell proliferation. Science 246:603–608
Quayum A, Gullick WJ, Clayton RC, Sikora K and Waxman J (1990) High affinity receptors for gonadotrophin-releasing hormone are present in human prostate cancer. Br J Cancer 62:96–99
Rauscher III FJ, Morris JF, Tournay OE, Cook DM and Curran T (1990) Binding of the Wilms’ tumour locus zinc finger protein to the EGR-1 consensus sequence. Science 250:1259–1262
Rayter SI, Iwata KK, Michitsch RW, Sorvillo JM, Valenzuela DM and Foulkes JG (1989) Biochemical function of oncogenes. In: Glover DM, Hames BD (eds) Oncogenes. Oxford University Press, Oxford, pp 113–189
Robey PG, Young MF and Flanders KC, et al. (1987) Osteoblasts synthesize and respond to TGF-beta in vitro. J Cell Biol 105:457–463
Rozengurt E (1986) Early signals in the mitogenic response. Science 234:161–166
Russell P and Nurse P (1986) cdc25 + functions as an inducer in mitotic control of fission yeast. Cell 45:145–153
Shaw PE, Schroter H and Nordheim A (1989a) The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter. Cell 56:563–572
Shaw PE, Frasch S and Nordheim A (1989b) Repression of c-fos transcription is mediated through p67SRF bound to the SRE. EMBO J 8:2567–2574
Shohat O, Greenberg M, Reisman D, Oren M and Rotter V (1987) Inhibition of cell growth mediated by plasmids encoding p53 anti-sense. Oncogene 1:277–283
Silberstein GB and Daniel CW (1987) Reversible inhibition of mammary gland growth by transforming growth factor p. Science 237:291–293
Sporn MB and Todaro GJ (1989) Autocrine secretion and malignant transformation of cells. N Engl J Med 303:878–880
Treisman R (1990) The SRE: a growth factor responsive transcriptional regulator. Semin Cancer Biol 1:47–58
Ullrich A and Schlessinger J (1989) Signal transduction by receptors with tyrosine kinase activity. Cell 61:203–212
Weinstein BI (1988) The origins of human cancer: molecular mechanisms of carcinogenesis and their implications for cancer prevention and treatment - Twenty-seventh G.H. A. Clowes Memorial Award Lecture. Cancer Res 48:4135–4143
Wilkinson DG, Bhatt S, Ryseck R-P and Bravo R (1989) Tissue specific expression of c-jun and jun-B during organogenesis in the mouse. Development 106:465–471
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Hollywood, D.P., Lemoine, N.R. (1992). Growth Factors, Oncogenes and Tumour Suppressor Genes. In: Hall, P.A., Levison, D.A., Wright, N.A. (eds) Assessment of Cell Proliferation in Clinical Practice. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68287-5_2
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DOI: https://doi.org/10.1007/978-4-431-68287-5_2
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68289-9
Online ISBN: 978-4-431-68287-5
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