Skip to main content
SpringerLink
Log in
Book cover

New Advances in Histamine Research pp 293–324Cite as

Pharmacology of newly developed H1 antagonists: antiallergic profile of H1 antagonists

  • Chapter

  • 94 Accesses

Abstract

In 1937, the first antihistarninic compound was found by Bovet and Staub in one of a series of amines with a phenolic ether function. Although this compound, 2-isopropyl-5- methylphenoxyethyldiethylamine, protected guinea pigs not only from several lethal doses of histamine but also from the symptoms of anaphylactic shock, this drug was too toxic for clinical use. As a result of the following search for a histamine antagonist, pyrilamine maleate was found as one of the most specific and effective histamine antagonists in the early 1940’s. By the early 1950’s, many compounds having antihistaminic property had been described (Douglas, 1985). However, all these classical histamine antagonists (H1 antagonists) caused central side effects such as sedation, lassitude and drowsiness (Wyngaarden and Seevers, 1951). In addition, concurrent ingestion of alcohol and other eNS depressants produced an additive effect in impairing eNS actions, such as disturbing motor skills (Garrison, 1990).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Akagi, M., Mio, M., Tasaka, K. and Kiniwa, S.: Mechanism of histamine release inhibition induced by azelastine. Pharmacometrics, 26, 191–198 (1983)

    CAS  Google Scholar 

  • Akagi, M., Mio, M., Miyoshi, K and Tasaka, K: Antiallergic effects of terfenadine on immediate type hypersensitivity reactions. Immunopharmacol. Immunotoxicol., 9, 257–279 (1987)

    Article  CAS  Google Scholar 

  • Akagi, M. and Tasaka, K: Analysis of bronchomotor tone in anesthetized guinea pigs by impedance plethysmography: a simple method for the evaluation of bronchodilator action. Meth. Find. Exp. Clin. Pharmacol., 10, 143–150 (1988)

    CAS  Google Scholar 

  • Arunlakshana, O.: Histamine release by antihistamines. J. Physiol., 119, 47–48P (1953)

    Google Scholar 

  • Awouters, F.H.L., Niemegeers, C. J. E. and Janssen, P.A.J.: Pharmacology of the specific histamine H1-antagonist astemizole. Arzneim.-Forsch., 33, 381–388 (1983)

    CAS  Google Scholar 

  • Beaven, M.A., Rogers, J., Moore, J.P., Hesketh, T.R., Smith, G.A. and Metcalfe, J.C.: The mechanism of the calcium signal and correlation with histamine release in 2H3 cells. J. Biol. Chem., 259, 7129–7136 (1984)

    PubMed  CAS  Google Scholar 

  • Bende, M. and Pipkorn, U.: Topical levocabastine, a selective H1 antagonist, in seasonal allergic rhinoconjunctivitis. Allergy, 42, 512–515 (1987)

    Article  PubMed  CAS  Google Scholar 

  • Bergmann, F., Costin, A. and Gutman, J.: A low threshold convulsive area in the rabbit’s mesencephalon. EEG Clin. Neurophysiol., 15, 683–690 (1963)

    CAS  Google Scholar 

  • Bovet, D. and Staub, A.-M.: Action protectrice des éthers phénoliques au cours de l’intoxication histaminique. C.R. Soc. Biol., 124, 547–549 (1937)

    CAS  Google Scholar 

  • Chand, N., Harrison, J.E., Rooney, S.M., Sofia, R.D. and Diamantis, W.: Inhibition of passive cutaneous anaphylaxis (PCA) by azelastine: Dissociation of its antiallergic activities from antihistaminic and antiserotonin properties. Int. J. Immunopharmacol., 7, 833–838 (1985)

    Article  PubMed  CAS  Google Scholar 

  • Church, M. K and Gradidge, C.F.: Inhibition of histamine release from human lung in vitro by antihistamines and related drugs. Br. J. Pharmacol., 69, 663–667 (1980)

    PubMed  CAS  Google Scholar 

  • Cooley, J.W. and Tukey, J.S.: An algorithm for machine calculation of complex Fourier series. Math. Comput., 19, 267–301 (1965)

    Google Scholar 

  • Criscuoli, M., Subissi, A., Daffonchio, L. and Omini, C.: LG 30435, a new bronchodilator / antiallergic agent, inhibits PAF -acether induced platelet aggregation and bronchoconstriction. Agents Actions, 19, 246–250 (1986)

    Article  PubMed  CAS  Google Scholar 

  • de Groot, J.: The rat forebrain in stereotaxic coordinates, Verh. K Ned. Acad. Wet. Naturkund., 52, 1–40 (1959)

    Google Scholar 

  • Douglas, W.W.: Histamine and 5-hydroxytryptamine (serotonin) and their antagonist. In: Gilman, A.G., Goodman, L.S., Rall, T.W., Murad, F. (ed) Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 7th ed. Macmillan Publishing Co., New York., 524–627, 1985

    Google Scholar 

  • Fukuda, T., Morimoto, Y., Iemura, R., Kawashima, T., Tsukamoto, G. and Ito, K.: Effect of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)-benzimidazole difumarate (KB-2413), a new antiallergic, on chemical mediators. Arzneim.-Forsch., 34, 801–805 (1984)

    CAS  Google Scholar 

  • Fügner, A., Bechtel, W.D., Kuhn, F.J. and Mierau, J.: In vitro and in vivo studies of the non-sedating antihistamine epinastine. Arzneim. - Forsch., 38, 1446–1453 (1988)

    Google Scholar 

  • Garrison, J.C.: Histamine, bradykinin, 5-hydroxytryptamine, and their antagonists, In: Gilman, A.G., Rall, T.W., Nies, A.S. and Taylor, P. (ed) Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 8th ed. Pergamon Press, New York, pp.575–599,. 1990

    Google Scholar 

  • Goldstein, L., Murphree, H.B., Pfeiffer, C.C: Comparative study of EEG effects of antihis tamines in nonnal volunteers. J. Clin. Phannacol., 8, 42–53 (1968)

    CAS  Google Scholar 

  • Guesdon, J.L., Chevrier, D., Mazié, J.C., David, B. and Avrameas, S.: Monoclonal antihistamine antibody, preparation, characterization and application to enzyme immunoassay of histamine. J. Immunol. Methods, 87, 69–78 (1986)

    Article  PubMed  CAS  Google Scholar 

  • Hall, C.S.: Emotional behavior in the rat. III. The relationship between emotionality and ambulatory activity. J. Compo Psychol., 22, 345–352 (1936)

    Article  Google Scholar 

  • Hayashi, H., Ichikawa, A., Saito, T. and Tomita, K: Inhibitory role of cyclic adenosine 3′, 5′ -monophosphate in histamine release from rat peritoneal mast cells in vitro. Biochem. Phannacol., 25, 1907–1913 (1976)

    CAS  Google Scholar 

  • Kamei, C., Kiniwa S., Ikegami, N. and Tasaka, K: Effect of 4-(p-chlorobenzyl)-[Nmethylperhydroazepinyl-(4)] -1-(2H)-phthalazinone hydrochloride (azelastine) on EEGs and behavior in rats. Jpn. J. Clin. Pharmacol. Ther., 12, 297–310 (1981)

    Article  CAS  Google Scholar 

  • Kamei, C., Akahori, H. and Tasaka, K: Influence of histamine and related compounds on the hypnotic effect of thiopental in mice. J. Pharmacobio-Dyn., 9, 112–116 (1986)

    Article  PubMed  CAS  Google Scholar 

  • Kamei, C., Chung, Y.H. and Tasaka, K: Influence of certain H1-blockers on the stepthrough active avoidance response in rats. Psychopharmacology, 102, 312–318 (1990)

    Article  PubMed  CAS  Google Scholar 

  • Kamei, C., Mio, M., Izushi, K, Kitazumi, K, Tsujimoto, S., Fujisawa, K, Adachi, Y. and Tasaka, K: Antiallergic effects of major metabolites of astemizole in rats and guinea pigs. Arzneim.-Forsch., 41, 932–936 (1991a)

    CAS  Google Scholar 

  • Kamei, C., Mio, M., Izushi, K, Yoshii, N., Fujisawa, K, and Tasaka, K: Inhibitory effect of MY-1250 on histamine release from rat peritoneal mast cells and guinea pig lung fragments: The elucidation of the mechanism. Immunophannacol. Immunotoxicol., 13, 341–356 (1991b)

    Article  CAS  Google Scholar 

  • Kamei, C., Izushi, K and Tasaka, K: Inhibitory effect of levocabastine on experimental allergic conjunctivitis in guinea pigs. J. Phannacobio-Dyn., 14, 467–473 (1991c)

    Article  CAS  Google Scholar 

  • Kamei, C., Akagi, M., Mio, M., Kitazumi, K, Izushi, K, Masaki, S. and Tasaka, K: Antiallergic effect of epinastine (W AL 801 CL) on immediate hypersensitivity reactions: (I) Elucidation of the mechanism for histamine release inhibition. Immunophannacol. Immunotoxicol., 14, 191–205 (1992a)

    Article  CAS  Google Scholar 

  • Kamei, C., Mio, M., Kitazumi, K, Tsujimoto, S., Yoshida, T., Adachi, Y. and Tasaka, K: Antiallergic effect of epinastine (WAI 801 CL) on immediate hypersensitivity reactions: (II) Antagonistic effect of epinastine on chemical mediators, mainly antihistaminic and anti-PAF effects. Immunophannacol. Immunotoxicol., 14, 207–218 (1992b)

    Article  CAS  Google Scholar 

  • Kamei, C., Okumura, Y. and Tasaka, K: Influence of histamine depletion on learning and memory recollection in rats. Psychophannacology, 111, 376–382 (1993)

    Article  CAS  Google Scholar 

  • Kaneko, T., Kitahara, A., Ozaki, S., Takizawa, K and Yamatsu, K: Effects of azelastine hydrochloride, a novel anti-allergic drug, on the central nervous system. Arzneim. - Forsch., 31, 1206–1212 (1981)

    CAS  Google Scholar 

  • Kebabian, J.W., Petzold, G.L. and Greegard, P.: Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the “Dopamine Receptor”. Proc. Natl. Acad. Sci., 69, 2145–2149 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Koster, R., Anderson, M. and de Beer, E.J.: Acetic acid for analgesic screening. Fed. Proc., 18, 412 (1959)

    Google Scholar 

  • Kojima, M., Tsutsumi, N., Abe, M., Komatsu, H., Ujiie, A., Naito, J. and Nakazawa, M.: Experimental allergic rhinitis in rats and the influence of tranilast and antihistaminics on it. Jpn. J. Allergol., 35, 180–187 (1986)

    CAS  Google Scholar 

  • Kreindler, A., Zuckermann, E., Steriade, M. and Chimion, D.: Electroclinical features of convulsions induced by stimulation of brain stem. J. Neurophysiol., 21, 430–436 (1958)

    PubMed  CAS  Google Scholar 

  • Lau, H.Y.A. and Pearce, F.L.: Dual effect of antihistamines on rat peritoneal mast cells: induction and inhibition of histamine release. Agents Actions, 16, 176–178 (1985)

    Article  PubMed  CAS  Google Scholar 

  • Leavitt, M.D. and Code, C.F.: Anesthetic action of beta-dimethylaminoethyl benzhydryl ether hydrochloride (benadryl) in the skin of human beings. Proc. Soc. expo Biol. (N.Y.), 65, 33–38 (1947)

    CAS  Google Scholar 

  • Levine, B.B. and Vaz, N.M.: Effect of combinations of inbred strain, antigen, and antigen dose on immune responsiveness and reagin production in the mouse. Int. Arch. Allergy, 39, 156–171 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Lewis, A.J., Dervinis, A. and Chang, J.: The effects of antiallergic and bronchodilator drugs on platelet-activating factor (PAF-acether) induced bronchospasm and platelet aggregation. Agents Actions, 15, 636–642 (1984)

    Article  PubMed  CAS  Google Scholar 

  • Loeffler, L.J., Lovenberg, W. and Sjoerdsma, A.: Effects of dibutyryl-3′, 5′-cyclic adenosine monophosphate, phosphodiesterase inhibitors and prostaglandin E1 on compound 48/80-induced histamine release from rat peritoneal mast cells in vitro. Biochem. Pharmacol., 20, 2287–2297 (1971)

    CAS  Google Scholar 

  • McManus, L.M., Hanahan, D.J., Demopoulos, C.A. and Pinckard, RN.: Pathobiology of the intravenous infusion of acetyl glyceryl ether phosphorylcholine (AGEPC), a synthetic platelet-activating factor (PAF), in the rabbit. J. Immunol., 124, 2919–2924 (1980)

    PubMed  CAS  Google Scholar 

  • Martin, U. and Römer, D.: The pharmacological properties of a new, orally active antianaphylactic compound: Ketotifen, a benzocycloheptathiophene. Arzneim. - Forsch., 28, 770–782 (1978)

    CAS  Google Scholar 

  • Mota, I.: The mechanism of anaphylaxis. I. Production and biological properties of ‘mast cell sensitizing’ antibody. Immunology, 7, 681–699 (1964)

    PubMed  CAS  Google Scholar 

  • Naranjo, P. and Naranjo, E.B. De: Local anesthetic activity of some antihistamines and its relationship with the antihistaminic and anticholinergic activities. Arch. int. Pharmacodyn., 113, 313–335 (1958)

    PubMed  CAS  Google Scholar 

  • Nemeth, A. and Röhlich, P.: Rapid separation of rat peritoneal mast cells with Percoll. Eur. J. Cell Biol., 20, 272–275 (1980)

    PubMed  CAS  Google Scholar 

  • Ohmori, K, Ishii, H., Kubota, T., Shuto K and Nakamizo, N.: Inhibitory effects of oxatomide on several activities of SRS-A and synthetic leukotrienes in guinea pigs and rats. Arch. int. Pharmacodyn., 275, 139–150 (1985)

    PubMed  CAS  Google Scholar 

  • Ohmori, K, Ishii, H., Shuto, K and Nakamizo, N.: Pharmacological studies on oxatomide: (4) Effect on the histamine release from rat isolated peritoneal exudate cells (PEC) and lung slices. Folia pharmacol. japon., 80, 441–449 (1982)

    Article  CAS  Google Scholar 

  • Patel, KR: The effect of calcium antagonist, nifedipine in exercise-induced asthma. Clin. Allergy, 11, 429–432 (1981)

    Article  PubMed  CAS  Google Scholar 

  • Pellerat, J. and Murat, M.: Action des antihistaminiques de synthese sur l’histaminemie. C.R Soc. Biol. (Paris), 140, 297 (1946)

    CAS  Google Scholar 

  • Pöch, G.: Assay of phosphodiesterase with radioactively labeled cyclic 3′, 5′-AMP as substrate. Naunyn-Schmiedebergs Arch. Pharmak., 268, 272–299 (1971)

    Google Scholar 

  • Ritchie, D.M., Sierchio, J.N., Bishop, C.M., Hedli, C.C., Levinson, S.L. and Capetola, R J.: Evaluation of calcium entry blockers in several models of immediate hypersensitivity. J. Phannacol. Exp. Ther., 229, 690–695 (1984)

    CAS  Google Scholar 

  • Ross, E.M., Maguire, M.E., Sturgill, T.W., Biltonen, R.L. and Gilman, A.G.: Relationship between the β-adrenergic receptor and adenylate cyclase. J. Biol. Chern., 252, 5761–5775 (1977)

    CAS  Google Scholar 

  • Siraganian, R.P.: An automated continuous-flow system for the extraction and fluorometric analysis of histamine. Anal. Biochem., 57, 383–394 (1974)

    CAS  Google Scholar 

  • Spataro, AC. and Bosmann, H.B.: Mechanism of action of disodium cromoglycate-mast cell calcium ion influx after a histamine-releasing stimulus. Biochem. Phannacol., 25, 505–510 (1976)

    Article  CAS  Google Scholar 

  • Shore, P.A., Burkhalter, A and Cohn, V.H.: A method for the fluorometric assay of histamine in tissues. J. Pharmacol. Exp. Ther., 127, 182–187 (1959)

    PubMed  CAS  Google Scholar 

  • Swinyard, E.A, Jolley, J.M. and Goodman, L.S.: Anticonvulsant properties of benadryl and pyribenzamine. Proc. Soc. Exp. Biol. Med., 75, 239–242 (1950)

    PubMed  CAS  Google Scholar 

  • Tada, T. and Okumura, K.: Regulation of homocytotropic antibody formation in the rat. I. Feed-back regulation by passively administered antibody. J. Immunol., 106, 1002–1011 (1971)

    PubMed  CAS  Google Scholar 

  • Tasaka, K.: Histamine release and its inhibition by antihistamines. Folia pharmacol, japon., 53, 1029–1035 (1957)

    Article  CAS  Google Scholar 

  • Tasaka, K. and Akagi, M.: Anti-allergic properties of a new histamine antagonist, 4-(p-Chlorobenzyl)-2- [N-methyl-perhydroazepinyl-(4)]-1-(2H)-phthalazinone hydrochloride (Azelastine). Arzneim.-Forsch., 29, 488–493 (1979)

    CAS  Google Scholar 

  • Tasaka, K., Kamei C., Akahori H. and Kitazumi, K.: The effects of histamine and some related compounds on conditioned avoidance response in rats. Life Sci., 37, 2005–2014 (1985)

    Article  PubMed  CAS  Google Scholar 

  • Tasaka, K., Mio, M. and Okamoto, M.: Intracellular calcium release induced by histamine releasers and its inhibition by some antiallergic drugs. Ann. Allergy, 56, 464–469 (1986a)

    PubMed  CAS  Google Scholar 

  • Tasaka, K., Mio, M., Okamoto, M.: Changes in intracellular Ca2+ distribution of rat peritoneal mast cells before and after histamine release. Agents Actions, 18, 61–64 (1986b)

    Article  PubMed  CAS  Google Scholar 

  • Tasaka, K., Kamei C., Katayama, S., Kitazumi, K., Akahori, H. and Hokonohara, T.: Comparative study of various H1-blockers on neuropharmacological and behavioral effectS including 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl) benzimidazole difumarate (KB-2413), a new antiallergic agent. Arch. int. Pharmacodyn., 280, 275–291 (1986c)

    CAS  Google Scholar 

  • Tasaka, K., Akagi, M., Mio, M., Miyoshi, K. and Nakaya, N.: Inhibitory effects of oxatomide on intracellular Ca mobilization, Ca uptake and histamine release, using rat peritoneal mast cells. Int. Archs Allergy appl. Immun., 83, 348–353 (1987)

    Article  CAS  Google Scholar 

  • Tasaka, K., Akagi, M., Mio, M., Okamoto, M., Miyoshi, K. and Izushi, K.: Antiallergic effects of terfenadine on immediate type hypersensitivity reactions and the mechanisms of those actions. Jpn. Pharmacol. Ther., 16, 2465–2480 (1988)

    CAS  Google Scholar 

  • Tasaka, K., Chung, Y.H., Sawada, K. and Mio, M.: Excitatory effect of histamine on the arousal system and its inhibition by H1 blockers. Brain Res. Bull., 22, 271–275 (1989a)

    Article  PubMed  CAS  Google Scholar 

  • Tasaka, K., Kamei C., Tsujimoto, S., Chung, Y.H. and Nakano, S.: Effects of mequitazine and some other HI-blockers on the central nervous system. Pharmacometrics, 37, 509–516 (1989b)

    CAS  Google Scholar 

  • Tasaka, K., Kamei C., Nakano, S., Tsujimoto, S. and Chung, Y.H.: Effect of epinastine, a new antiallergic agent, on the central nervous system. Pharmacometrics, 38, 53–62 (1989c)

    CAS  Google Scholar 

  • Tasaka, K., Akagi, M., Izushi, K. and Mio, M.: Antiallergic effects of astemizole on immediate type hypersensitivity reactions. Meth. Find. Exp. Clin. Pharmacol., 12, 531–539 (1990a)

    CAS  Google Scholar 

  • Tasaka, K., Kamei, C., Chung, Y.H., Tsujimoto, S. and Mukai, T.: Influence of astemizole, a non-sedative H1-blocker on the central nervous system. Pharmacometrics., 39, 197–206 (1990b)

    CAS  Google Scholar 

  • Tasaka, K., Kamei, C., Tsujimoto, S., Yoshida, T. and Aoki, I.: Central effect of the potent long-acting H1-antihistamine levocabastine. Arzneim. - Forsch., 40, 1295–1299 (1990c)

    CAS  Google Scholar 

  • Tasaka, K., Akagi, M., Izushi, K. and Aoki, I.: Antiallergic effect of epinastine: the elucidation of the mechanism. Pharmacometrics, 39, 365–373 (1990d)

    CAS  Google Scholar 

  • Tasaka, K., Akagi, M., Mio, M., Izushi, K. and Aoki, I.: Anti-platelet activating factor, anti-leukotriene D4 and some other antiallergic activities of mequitazine. Arzneim. - Forsch., 40, 1092–1097 (1990e)

    CAS  Google Scholar 

  • Tasaka, K., Kamei, C., Akagi, M., Mio, M., Shirasaka, T. and Chokki, M.: Antiallergic profile of the novel H1-antihistaminic compound levocabastine. Arzneim.-Forsch., 43, 1331–1337 (1993)

    CAS  Google Scholar 

  • Tasaka, K., Kamei C. and Nakamura, S.: Inhibitory effect of epinastine on bronchoconstriction induced by histamine, platelet activating factor and serotonin in guinea pigs and rats. Arzneim. - Forsch., 44, 327–329 (1994a)

    CAS  Google Scholar 

  • Tasaka, K., Kamei, C. and Nakamura, S.: Effects of antiallergic agents including levocabastine on experimental rhinitis in rats. Arzneim.-Forsch., 44, 337–341 (1994b)

    CAS  Google Scholar 

  • Vargaftig, B.B., Lefort, J., Chignard, M. and Benveniste, J.: Platelet-activating factor induces a platelet-dependent bronchoconstriction unrelated to the formation of prostaglandin derivatives. European J. Pharmacol., 65, 185–192 (1980)

    CAS  Google Scholar 

  • Venuti M.C.: Platelet-activating factor: multifaceted biochemical and physiological mediator. Ann. Rep. Med. Chern., 20, 193–202 (1985)

    Article  CAS  Google Scholar 

  • Wauwe, J. Van., Awouters, F., Niemegeers, C.J.E., Janssens, F., Neuten, J.M. Van and Janssen, P.A.J.: In vivo pharmacology of astemizole, a new type of HI-antihistaminic compound. Arch. int Pharmacodyn., 251, 39–51 (1981)

    PubMed  Google Scholar 

  • Weidmann, H. and Petersen, P.V.: A new group of potent sedatives. J. Pharmacol. Exp. Ther., 108, 201–216 (1953)

    PubMed  CAS  Google Scholar 

  • White, J.R., Ishizaka, T., Ishizaka, K. and Sha’afi R.I.: Direct demonstration of increased intracellular concentration of free calcium as measured by quin-2 in stimulated rat peritoneal mast cell. Proc. Natl. Acad. Sci. U.S.A., 81, 3978–3982 (1984)

    Article  PubMed  CAS  Google Scholar 

  • Winter, C.A. The potentiating effect of antihistaminic drugs upon the sedative action of barbiturates. J. Pharmacol. Exp. Ther., 94, 7–11 (1948)

    PubMed  CAS  Google Scholar 

  • Winter, C.A. and Flataker, L.: The effect of antihistaminic drugs upon the performance of trained rats. J. Pharmacol. Exp. Ther., 101, 156–162 (1951)

    PubMed  CAS  Google Scholar 

  • Wyngaarden, J.B. and Seevers, M.H.: The toxic effects of antihistaminic drugs. J. Amer. Med. Ass., 145, 277–282 (1951)

    Article  CAS  Google Scholar 

  • Yamasaki, H. and Tasaka, K.: Dual action of antihistamines on histamine release. Acta Med. Okayama, 11, 290–299 (1957)

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Department of Pharmacology in the Faculty of Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-Naka, 700, Okayama, Japan

    Kenji Tasaka M.D., PH.D. (Chairman and Professor)

Authors
  1. Kenji Tasaka M.D., PH.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer-Verlag Tokyo

About this chapter

Cite this chapter

Tasaka, K. (1994). Pharmacology of newly developed H1 antagonists: antiallergic profile of H1 antagonists. In: New Advances in Histamine Research. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68263-9_9

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-68263-9_9

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68265-3

  • Online ISBN: 978-4-431-68263-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation