From the early years of the introduction of H2 antagonists for clinical uses, many reports have been published that H2 antagonists induce various kinds of cytopenia, such as neutropenia, agranulocytosis, thrombocytopenia, pancytopenia and lymphopenia. At the present time, it has become evident that histamine exerts a stimulative effect on the differentiation and proliferation of bone marrow stem cells, especially in neutrophil progenitors, via an H2 receptor stimulation (Tasaka, 1991). However, as early as 8 years before the discovery of the H2 receptor and histamine H2 antagonist by Black et al. (1972), Tasaka and Code (1964) reported that chronic injection of histamine induces leukocytosis in various kinds of experimental animals. This was the first report which clearly pointed out the hematopoietic action of histamine in vivo. A growing body of evidence indicates that histamine is not only a physiological hematopoietic substance but also that it interacts with other hematopoietic cytokines, such as granulocytic colony stimulating factor (G-CSF) and interleukin-1α (IL-1), at physiological concentration range. The stimulative effect of histamine on several leukemia cells has also been reported (Nonaka et al., 1992). In this chapter, the mechanism of histamine-induced leukocytosis is reviewed.
KeywordsBone Marrow Stromal Cell Murine Bone Marrow cAMP Content Human Promyelocytic Leukemia Cell Histamine Antagonist
Unable to display preview. Download preview PDF.
- Akiyama Y., Mukai T., Kamei C. and Tasaka K. (1990) Histamine lipolysis I: Changes in the free fatty acid levels of dog plasma after intravenous infusion of histamine. Meth. Find. Exp. Clin. Pharmacol., 12: 315–324Google Scholar
- Black J.W., Duncan W.A.M., Durant G.J., Gannelin C.R. and Parsons M.E.: Definition and antagonism of histamine H2-receptors. Nature, 236: 385–390Google Scholar
- Code C.F. (1976) Suppression of histamine leucocytosis by metiamide. J. Physiol. (Lond.) 254: 31P-32PGoogle Scholar
- de Galoscy C. and van Ypersele de Strihou C. (1979) Pancytopenia with cimetidine. Ann. Intern. Med., 90: 274Google Scholar
- Fibbe W.E., Damme J.V., Billiau A., Goselink H.M., Voogt P.J., Eeden G.V., Ralph P., Altrock B.W. and Falkenburg J.H.F. (1988) Interleukin 1 induces human marrow stromal cells in long-term culture to produce granulocyte colony-stimulating factor and macrophage colony-stimulating factor. Blood 71: 430–435PubMedGoogle Scholar
- Hay L.J., Vacro R.L., Code C.F. and Wangensteen O.H. (1942) The experimental production of gastric and duodenal ulcers in laboratory animals by the intramuscular injection of histamine in beeswax. Surg. Gynecol. Obstet., 75: 170–182Google Scholar
- Kase H., Iwahashi K., Nakanishi S., Matsuda Y., Yamada K., Takahashi M., Murakata C., Sato A. and Kaneko M. (1987) K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Biochem. Biophys. Res. Commun., 142: 436–440PubMedCrossRefGoogle Scholar
- Kobayasi Y., Appella E., Yamada M., Copeland T.D., Oppenheim J.J. and Matsushima K. (1988) Phosphorylation of intracellular receptors of human IL-1. J. Immunol., 140: 2279–2287Google Scholar
- Schwartz J.-C., Arrang J.-M., Bouthenet M.-L., Garbarg M., Pollard H. and Raut M. (1991) Histamine receptors in brain, in ‘Handbook of Experimental Pharmacology, vol. 97. Histamine and histamine antagonists’ (ed. Uväns B.), Springer-Verlag, Berlin, pp. 191–242Google Scholar
- Tasaka K. (1991) Histamine and the Blood, in ‘Handbook of Experimental Pharmacology, vol. 97. Histamine and histamine antagonists’ (ed. Uvnäs B.), Springer-Verlag, Berlin, pp. 473–510Google Scholar
- Tasaka K. and Code C.F. (1964) Histamine leukocytosis. Fed. Proc. 23: 471Google Scholar
- Tasaka K., Nakaya N. and Code C.F. (1992a) Histamine leukocytosis. I. Effect of histamine on peripheral leukocyte counts. Meth. Find. Exp. Clin. Pharmacol., 14: 667–675Google Scholar
- Tasaka K., Shorter R.G. and Code C.F. (1992b) Histamine leukocytosis. II. Source of histamine leukocytosis. Meth. Find. Exp. Clin. Pharmacol., 14: 799–804Google Scholar