Histamine release induced by basic peptides and proteins
Histamine release from mast cells is elicited not only by immunological stimuli but also various substances (Uvnäs, 1974; Tasaka, 1986; Foreman, 1988; Akagi and Tasaka 1991). Among them, it is of importance to elucidate the mechanism of histamine release induced by biological substances, such as neuropeptides or proteins, in association with the pathogenesis of allergic reactions. In this chapter, the histamine release induced by substance P, histone and eosinophil major basic protein was investigated.
KeywordsMast Cell Histamine Release Peritoneal Mast Cell Major Basic Protein Partial Amino Acid Sequence
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