Histamine release induced by basic peptides and proteins

  • Kenji Tasaka


Histamine release from mast cells is elicited not only by immunological stimuli but also various substances (Uvnäs, 1974; Tasaka, 1986; Foreman, 1988; Akagi and Tasaka 1991). Among them, it is of importance to elucidate the mechanism of histamine release induced by biological substances, such as neuropeptides or proteins, in association with the pathogenesis of allergic reactions. In this chapter, the histamine release induced by substance P, histone and eosinophil major basic protein was investigated.


Mast Cell Histamine Release Peritoneal Mast Cell Major Basic Protein Partial Amino Acid Sequence 
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Copyright information

© Springer-Verlag Tokyo 1994

Authors and Affiliations

  • Kenji Tasaka
    • 1
  1. 1.The Department of Pharmacology in the Faculty of Pharmaceutical SciencesOkayama UniversityOkayamaJapan

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