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New Advances in Histamine Research pp 97–167Cite as

Role of Ca2+ and cAMP in histamine release from mast cells

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Abstract

It is well known that an increase in intracellular Ca2+ concentrations and subsequent activation of Ca2+ -dependent pathways, such as calmodulin, protein kinase C and cytoskeletons, are prerequisite for the histamine release from mast cells. On the other hand, an increase in intracellular concentrations of cAMP is effective in inhibiting the histamine release from mast cells. Many antiallergic drugs have been developed based on this consequence either to inhibit the increase in intracellular Ca2+ level or to increase intracellular cAMP concentrations of mast cells. In this chapter, the roles of Ca2+ and cAMP in the histamine release from mast cells are reviewed.

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Authors and Affiliations

  1. The Department of Pharmacology in the Faculty of Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-Naka, 700, Okayama, Japan

    Kenji Tasaka M.D., PH.D. (Chairman and Professor)

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  1. Kenji Tasaka M.D., PH.D.
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© 1994 Springer-Verlag Tokyo

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Tasaka, K. (1994). Role of Ca2+ and cAMP in histamine release from mast cells. In: New Advances in Histamine Research. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68263-9_4

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  • DOI: https://doi.org/10.1007/978-4-431-68263-9_4

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68265-3

  • Online ISBN: 978-4-431-68263-9

  • eBook Packages: Springer Book Archive

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