Role of Ca2+ and cAMP in histamine release from mast cells

  • Kenji Tasaka


It is well known that an increase in intracellular Ca2+ concentrations and subsequent activation of Ca2+ -dependent pathways, such as calmodulin, protein kinase C and cytoskeletons, are prerequisite for the histamine release from mast cells. On the other hand, an increase in intracellular concentrations of cAMP is effective in inhibiting the histamine release from mast cells. Many antiallergic drugs have been developed based on this consequence either to inhibit the increase in intracellular Ca2+ level or to increase intracellular cAMP concentrations of mast cells. In this chapter, the roles of Ca2+ and cAMP in the histamine release from mast cells are reviewed.


Mast Cell Histamine Release Dantrolene Sodium Induce Histamine Release Inhibit Histamine Release 
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  1. Abdel-Latif A.A. (1986) Calcium-mobilizing receptors, polyphosphoinositides, and the generation of second messengers. Pharmacol Rev., 38: 227–272PubMedGoogle Scholar
  2. Ahnert-Hilger G., Bhakdi S. and Gratzl (1985) Minimal requirements for exocytosis: a study using PC12 cells permeabilized with staphylococcal α-toxin. J. Biol Chem., 260: 12730–12734PubMedGoogle Scholar
  3. Akagi M., Mio M., Tasaka K and Kiniwa S. (1983) Mechanism of histamine release inhibition induced by azelastine. Pharmacometrics, 26: 191–198Google Scholar
  4. Alm P.E. and Bloom G.D. (1982) Cyclic nucleotide involvement in histamine release from mast cells. A reevaluation. Life Sci., 30: 213–218PubMedCrossRefGoogle Scholar
  5. Amende L.M. and Donlon M.A. (1985) Isolation of cellular membranes from rat mast cells. Biochim. Biophys. Acta, 812: 713–720PubMedCrossRefGoogle Scholar
  6. Ala’i R. and Ralph R.K (1986) Cyclic AMP and Ca2+ uptake by mastocytoma mitochondria. Ceo. Calcium, 7: 13–27CrossRefGoogle Scholar
  7. Baker P.F. and Knight D.E. (1981) Calcium control of exocytosis and endocytosis in bovine adrenal medullary cells. Phil Trans. R Soc. Lond. B. Biol Sci., 296: 83–103CrossRefGoogle Scholar
  8. Baldassare J.J., Knipp M.A., Henderson P.A. and Fisher G.J. (1988) GTPγS-stimulated hydrolysis of phosphatidylinositol-4, 5-bisphosphate by soluble phospholipase C from human platelets requires soluble GTP-binding protein. Biochem. Biophys. Res. Commun., 154: 351–357PubMedCrossRefGoogle Scholar
  9. Barrett KE. and Pearce F.L. (1983) A comparison of histamine secretion from isolated peritoneal mast cells of the mouse and rat. Int. Arch. Allergy Appl. Immunol., 72: 234–238PubMedCrossRefGoogle Scholar
  10. Beaven M.A., Roger J., Moore J.P. Hesketh T.R., Smith G.A. and Metcalfe J.C. (1984) The mechanism of the calcium signal and correlation with histamine release in 2H3 cells. J. Biol. Chem., 259: 7129–7136PubMedGoogle Scholar
  11. Bennet J.P., Cockcroft S. and Gomperts B.D. (1981) Rat mast cells permeabilized with ATP secrete histamine in response to calcium ions buffered in the micromolar range. J. Physiol., 317: 335–345Google Scholar
  12. Berridge M.J. (1984) Inositol trisphosphate and diacylglycerol as second messengers. Biochem. J., 220: 345–360PubMedGoogle Scholar
  13. Berridge M.J. and Irvine R.F. (1984) Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature, 312: 315–321PubMedCrossRefGoogle Scholar
  14. Borgers M., Thone F.J.M., Xhonneux B.J.M. and de Clerck F.F.P. (1983) Localization of calcium in red blood cells. J. Histochem. Cytochem., 31: 1109–1116PubMedCrossRefGoogle Scholar
  15. Brass L.F. and Joseph S.K (1985) A role for inositol triphosphate in intracellular Ca2+ mobilization and granule secretion in platelets. J. Biol. Chem., 260: 15172–15179PubMedGoogle Scholar
  16. Burgess G.M., McKinney J.S., Fabiato A., Leslie B.A. and Putney J.W. (1983) Calcium pools in saponin-penneabilized guinea pig hepatocytes. J. Biol. Chem., 258: 15336–15345PubMedGoogle Scholar
  17. Burgoyne RD. (1987) Control of exocytosis. Nature, 328: 112–113PubMedCrossRefGoogle Scholar
  18. Cantley L.C., Josephson L., Warner R, Yanagisawa M., Lechene C. and Guidotti G. (1977) Vanadate is a potent (Na, K)-ATPase inhibitor found in ATP derived from muscle. J. Biol. Chem., 252: 7421–7423PubMedGoogle Scholar
  19. Cantwell M.E. and Foreman J.C. (1987) Phorbol esters induced a slow, non-cytotoxic release of histamine from rat peritoneal mast cells. Agents Actions, 20: 165–168PubMedCrossRefGoogle Scholar
  20. Castagna M., Takai Y., Kaibuchi K, Sano K, Kikkawa U. and Nishizuka Y. (1982) Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J. Biol. Chem., 257: 7847–7851PubMedGoogle Scholar
  21. Chakravarty N. and Nielsen E.M. (1985) Calmodulin in mast cells and its role in histamine release. Agents Actions, 16: 122–125PubMedCrossRefGoogle Scholar
  22. Chiou C.Y. and Malagodi M.H. (1975) Studies on the mechanism of action of a new Ca2+ antagonist, 8-(N, N-diethylamino)-octyl 3, 4, 5-trimethoxybenzoate hydrochloride in smooth and skeletal muscles. Br. J. Pharmacol., 53: 279–285PubMedGoogle Scholar
  23. Church M.K and Gradidge C.F. (1980) Oxatomide: inhibition and stimulation of histamine release from human lung and leukocytes in vitro. Agents Actions, 10: 4–7PubMedCrossRefGoogle Scholar
  24. de Clark F.,. van Reempts J. and Borgers M. (1981) Comparative effects of oxatomide on the release of histamine from rat peritoneal mast cells. Agents Actions, 11: 184–192CrossRefGoogle Scholar
  25. Cockcroft S., Barrowman M.M. and Gomperts B.D. (1985) Breakdown and synthesis of polyphosphoinositides in fMet-Leu-Phe stimulated neutrophils. FEBS Lett., 181: 259–263PubMedCrossRefGoogle Scholar
  26. Coussens L., Parker P.J., Rhee L., Yang-Feng T.L., Chen E., Waterfield M.D., Francke U. and Ullrich A. (1986) Multiple, distinct fonns of bovine and human protein kinase C suggest diversity in cellular signaling pathways. Science, 233: 859–866PubMedCrossRefGoogle Scholar
  27. Curtis B.M. and Catterall W.A. (1985) Phosphorylation of the calcium antagonist receptor of the voltage-sensitive calcium channel by cAMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA, 82: 2528–2532PubMedCrossRefGoogle Scholar
  28. de Duve C., Pressman B.C., Gianetto R, Wattiaux R and Appelmans F. (1955) Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue. Biochem. J., 60: 604–617Google Scholar
  29. Edelman A.M., Blumenthal D.K and Krebs E.G. (1987) Protein serine-threonine kinase. Ann. Rev. Biochern., 56: 567–614CrossRefGoogle Scholar
  30. Endo M. (1977) Calcium release from the sarcoplasmic reticulum. Physiol. Rev., 57: 71–108PubMedGoogle Scholar
  31. Ennis M., Atkinson G and Pearce F.L. (1980a) Inhibition of histamine release induced by compound 48/80 and peptide 401 in the presence and absence of calcium. Implication for the mode of action of antiallergic compounds. Agents Actions, 10: 222–228PubMedCrossRefGoogle Scholar
  32. Ennis M., Truneth A., White J.R. and Pearce F.L. (1980b) Calcium pools involved in histamine release from rat mast cells. Int. Arch. Arch. Allergy Appl. Immunol., 62: 467–471CrossRefGoogle Scholar
  33. Fewtrell C.M.S., Foreman J.C., Jordan C.C., Oehme P., Renner H. and Stewart J.M. (1982) The effects of substance P on histamine release and 5-hydroxytryptamine release in the rat. J. Physiol., 330: 393–411PubMedGoogle Scholar
  34. Fox P.C., Basciano L.K and Siraganian RP. (1982) Mouse mast cell activation and desensitization for immune aggregate-induced histamine release. J. Immunol., 129: 314–319PubMedGoogle Scholar
  35. Garteiz D.A, Hook R.H., Walker B.J. and Okerholm R.A (1982) Pharmacokinetics and biotransfonnation studies of terfenadine in man. Arzneim. -Forsch., 32: 1185–1190Google Scholar
  36. Gennis R.B. (1989) Biomembranes. In Springer Advanced Texts in Chemistry. New York: Springer-VerlagGoogle Scholar
  37. Gomperts B.D. (1983) Involvement of guanine nucleotide-binding protein in the gating of Ca2+ by receptors. Nature, 306: 64–66PubMedCrossRefGoogle Scholar
  38. Grosman N. (1986) Effects of TMB-8 on histamine release from isolated rat mast cells. Int. Arch. Allergy Appl. Immunol., 79: 253–258CrossRefGoogle Scholar
  39. Haslam R.J., Davidson M.M.L., Davies T., Lynham J.A and McClenagham M.D. (1978) Regulation of blood platelet function by cyclic nucleotides. Adv. Cyclic Nucleotide Res., 9: 533–552PubMedGoogle Scholar
  40. Hata Y., Kaibuchi K, Kawamura S., Hiroyoshi M., Shirataki H. and Takai Y. (1991) Enhancement of the actions of smg p21 GDP/GTP exchange protein by protein kinase A-catalyzed phosphorylation of smg p21. J. Biol. Chem., 266: 6571–6577PubMedGoogle Scholar
  41. Hayashi H., Ichikawa A, Saito T. and Tomita K (1976) Inhibitory role of cyclic adenosine 3: 5-monophosphate in histamine release from rat peritoneal mast cells in vitro. Biochem. Pharmacol., 25: 1907–1913PubMedCrossRefGoogle Scholar
  42. Hidaka H. and Tanaka T. (1983) Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol., 102: 185–194PubMedCrossRefGoogle Scholar
  43. Hidaka H., Inagaki M., Kawamoto S. and Sasaki Y. (1984) Isoquinoline-sulfonamide, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry, 23: 5036–5041PubMedCrossRefGoogle Scholar
  44. Hirata M., Suematsu E., Hashimoto T., Hamachi T. and Koga T. (1984) Release of Ca2+ from a non-mitochondrial store site in peritoneal macro phages treated with saponin by inositol 1, 4, 5-trisphosphate. Biochem. J., 223: 229–236PubMedGoogle Scholar
  45. Hirata M., Kukita M., Sasaguri T., Suematsu E., Hashimoto T. and Koga T. (1985) Increase in Ca2+ penneability of intracellular Ca2+ store membrane of saponin-treated guinea pig peritoneal macrophage by inositol 1, 4, 5-trisphosphate. J. Biochem., 97: 1575–1582PubMedGoogle Scholar
  46. Howell T.W. and Gomperts B.D. (1987) Rat mat cells penneabilized with streptolysin O secrete histamine in response to Ca2+ at concentrations buffered in the micromolar range. Biochem. Biophys. Acta, 927: 177–183PubMedCrossRefGoogle Scholar
  47. Imai A, Ishizuka Y., Nakashima S. and Nozawa Y. (1984a) Differential activation of membrane phospholipid turnover by compound 48/80 and A23187 in rat mast cells. Arch. Biochem. Biophys., 232: 259–268PubMedCrossRefGoogle Scholar
  48. Imai S., Nakazawa H., Imai H. and Nabata H. (1984b) Effects of procaine on the isolated dog coronary artery. Arch. Int. Pharmacodyn., 271: 98–105PubMedGoogle Scholar
  49. Itoh T., Kanmura Y., Kuriyama H. and Sasaguri T. (1985) Nitroglycerine- and isoprenalineinduced vasodilatation: assessment from actions of cyclic nucleotides. Br. J. Pharmacol., 84: 393–406PubMedGoogle Scholar
  50. Izushi K and Tasaka K (1989) Histamine release from, β-escin-penneabilized rat peritoneal mast cells and its inhibition by intracellular Ca2+ blockers, calmodulin inhibitors and cAMP. Immunopharmacology, 18: 177–186PubMedCrossRefGoogle Scholar
  51. Izushi K and Tasaka K (1991) Essential role of A TP and possibility of activation of protein kinase C in Ca2+ -dependent histamine release from penneabilized rat peritoneal mast cells. Pharmacology, 42: 297–308PubMedCrossRefGoogle Scholar
  52. Izushi K. and Tasaka K. (1992) Ca2+ -induced translocation of protein kinase C during Ca2+ -dependent histamine release from beta-escin-penneabilized rat mast cells. Pharmacology, 44: 61–70PubMedCrossRefGoogle Scholar
  53. Izushi K., Fujiwara Y. and Tasaka K. (1992a) Identification of vimentin in rat peritoneal mast cells and its phosphorylation in association with histamine release. Immunopharmacology, 23: 153–161PubMedCrossRefGoogle Scholar
  54. Izushi K., Shirasaka T., Chokki M. and Tasaka K. (1992) Phosphorylation of smg p21B in rat peritoneal mast cells in association with histamine release by dibutyryl-cAMP. FEBS Lett., 314: 241–245PubMedCrossRefGoogle Scholar
  55. Johansen T. (1980) Adenosine triphosphate level during anaphylactic histamine release in rat mast cells in vitro. Effects of glycolytic and respiratory inhibitors. Eur. J. Pharmacol., 58: 107–115CrossRefGoogle Scholar
  56. Kase H., Iwahasi K., Nakanishi S., Matsuda Y., Yamada K., Takahashi M., Murakata C., Sato A. and Kaneko M. (1987) K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Biochem. Biophys. Res. Commun., 142: 436–440PubMedCrossRefGoogle Scholar
  57. Katakami Y., Kaibuchi K., Sawamura M., Takai Y. and Nishizuka Y. (1984) Synergic action of protein kinase C and calcium for histamine release from rat peritoneal mast cells. Biochem. Biophys. Res. Commun., 12: 573–578CrossRefGoogle Scholar
  58. Kawata M., Kikuchi A., Hoshijima M., Yamamoto K., Hashimoto E., Yamamura H and Takai Y. (1989) Phosphorylation of smg p21, a ras p21-like GTP-binding protein, by cyclic AMP-dependent protein kinase in a cell-free system and in response to prostaglandin E1 in intact human platelets. J. Biol. Chem., 264: 15688–15695PubMedGoogle Scholar
  59. Kennerly D.A. (1987) Diacylglycerol metabolism in mast cells. J. Biol. Chem., 262: 16305–16313PubMedGoogle Scholar
  60. Kennerly D.A., Sullivan T.J. and Parker C.W. (1979) Activation of phospholipid metabolism during mediator release from stimulated rat mast cells. J. Immunol., 122: 152–159PubMedGoogle Scholar
  61. Kikkawa U., Takai Y., Minakuchi R, Inohara S. and Nishizuka Y. (1982) Calcium-activated, phospholipid-dependent protein kinase from rat brain. J. Biol. Chem., 257: 13341–13348PubMedGoogle Scholar
  62. Knight D.E. and Scrutton M.C. (1984) Cyclic nucleotides control a system which regulates Ca2+ sensitivity of platelet secretion. Nature, 309: 66–68PubMedCrossRefGoogle Scholar
  63. Kobayashi E., Nakano H., Morimoto M., Tamaoki T. (1989) Calphostin C (UCN-I028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Commun., 159: 548–553PubMedCrossRefGoogle Scholar
  64. Koopmann W.R and Jackson RC. (1990) Calcium- and guanine-nucleotide-dependent exocytosis in penneabilized rat mast cells. Biochem. J., 265: 363–373Google Scholar
  65. Kosaka Y., Ogita K., Ase K., Nomura H., Kikkawa U. and Nishizuka Y. (1988) The heterogeneity of protein kinase C in various rat tissues. Biochem. Biophys. Res. Commun., 15: 973–981CrossRefGoogle Scholar
  66. Kreye V.A.W., Ruegg J.C. and Hofmann F. (1983) Effects of calcium-antagonist and calmodulin antagonist drugs on calmodulin dependent contractions of chemically skinned vascular smooth muscle from rabbit renal arteries. Naunyn-Schmied. Archs. Pharmacol., 323: 85–89CrossRefGoogle Scholar
  67. Kurosawa M. and Parker C.W. (1986) Characterization of calcium-activated, phospholipiddependent protein kinase from rat serosal mast cells and RBL-l cells. Cell. Immunol., 103: 381–393PubMedCrossRefGoogle Scholar
  68. Lapetina E.G. and Reep B.R. (1987) Specific binding of (α- 32P)GTP to cytosolic and membrane-bound proteins of human platelets correlates with the activation of phospholipase C. Proc. Nalt. Acad. Sci. USA, 84: 2261–2265CrossRefGoogle Scholar
  69. Lindau M. and NüBe O. (1987) Pertussis toxin does not effect the time course of exocytosis in mast cells stimulated by intracellular application of GTP-γ-S. FEBS Lett., 222: 317–321PubMedCrossRefGoogle Scholar
  70. Martonosi A.N. (1984) Mechanisms of Ca2+ release from sarcoplasmic reticulum of skeletal muscle. PhysioL Rev., 64: 1240–1320PubMedGoogle Scholar
  71. Mio M., Izushi K and Tasaka K (1991) Substance P-induced histamine release from rat peritoneal mast cells and its inhibition by antiallergic agents and calmodulin inhibitors. Immunopharmacowgy, 22: 59–66CrossRefGoogle Scholar
  72. Mitchell R.H. (1975) Inositol phospholipids and cell surface receptor function. Biochim. Biophys. Acta, 415: 81–147Google Scholar
  73. Nago S., Nagata K, Kohmura Y., Ishizuka T. and Nozawa Y. (1987) Redistribution of phospholipid/ Ca2+ -dependent protein kinase in mast cells activated by various agonists. Biochem. Biophys. Res. Commun., 142: 645–653CrossRefGoogle Scholar
  74. Nakamura T. and Vi M. (1985) Simultaneous inhibitions of inositol phospholipid breakdown, arachidonic acid release, and histamine secretion in mast cells by islet-activating protein, pertussis toxin. J. Biol. Chem., 260: 3584–3593PubMedGoogle Scholar
  75. Nishizuka Y. (1984) The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature, 308: 693–698PubMedCrossRefGoogle Scholar
  76. Nishizuka Y. (1986) Studies and perspectives of protein kinase C. Science, 233: 305–312PubMedCrossRefGoogle Scholar
  77. O’Farrell P.H. (1975) High resolution two dimensional electrophoresis of proteins. J. Biol. Chem., 250: 4007–4021PubMedGoogle Scholar
  78. O’Flaherty J.T., Jacobson D.P., Redman J.F. and Rossi A.G. (1990) Translocation of protein kinase C in human polymorphonuclear neutrophils. J. Biol. Chem., 265: 9146–9152PubMedGoogle Scholar
  79. Ohmori K, Ishii H., Takei Y., Shuto K and Nakamizo N. (1982a) Pharmacological studies of oxatomide. 3. Effect on experimental asthma and Schultz-Dale response in rats and guinea pigs. Folia Pharmacol. Jpn., 80: 481–493CrossRefGoogle Scholar
  80. Ohmori K, Ishii H., Takei Y., Shuto K and Nakamizo N. (1982b) Pharmacological studies of oxatomide. 4. Effect on the histamine release from rat isolated peritoneal mast cells (PEC) and lung slices. Folia Pharmacol. Jpn., 80: 441–449CrossRefGoogle Scholar
  81. Ohmori T., Kikuchi A., Yamamoto K, Kawata M., Kondo J. and Takai Y. (1988) Identification of a platelet Mr 22,000 GTP-binding protein as the novel smg-21 gene product having the same putative effector domain as the ras gene products. Biochem. Biophys. Res. Commun., 157: 670–676PubMedCrossRefGoogle Scholar
  82. Ohmori T., Kikuchi A., Yamamoto K, Kim S. and Takai Y. (1989) Small molecular weight GTP-binding proteins in human platelet membranes. Purification and characterization of a novel GTP-binding protein with a molecular weight of 22,000. J. Biol. Chem., 264: 1877–1881PubMedGoogle Scholar
  83. Ohsako S. and Deguchi T. (1983) Phosphatidic acid mimics the muscarinic action of acetylcholine in cultured bovine chromaffin cells. FEBS Lett., 152: 62–66PubMedCrossRefGoogle Scholar
  84. Pang D.C. and Sperelakis N. (1983) Nifedipine, diltiazem, bepridil and verapamil uptakes into cardiac and smooth muscles. Eur. J. Pharmacol., 87: 199–207PubMedCrossRefGoogle Scholar
  85. Parker P.J., Coussens L., Totty N., Rhee L., Young S., Chen E., Stabel S., Waterlield M. D. and Ullrich A. (1986) The complete primary structure of protein kinase C - The major phorbol ester receptor. Science, 233: 853–859PubMedCrossRefGoogle Scholar
  86. Patel KR (1981) The effect of calcium antagonist, nifedipine in exercise-induced asthma. Clin Allergy, 11: 429–432PubMedCrossRefGoogle Scholar
  87. Peppers S.C. and Holz R W. (1986) Catecholamine secretion from digitonin-treated PC12 cells: effects of Ca2+, ATP and protein kinase C activators. J. Biol. Chem., 261: 14665–14669PubMedGoogle Scholar
  88. Pershadsingh H.A. and McDonald J.M. (1980) A high affinity calcium-stimulated magnesiumdependent adenosine triphosphatase in rat adipocyte plasma membrane. J. Biol. Chem., 255: 4087–4093PubMedGoogle Scholar
  89. Pocotte S.L., Frye RA., Senter RA., TerBush D.R, Less S.A. and Holz RW. (1985) Effects of phorbol esters on catecholamine secretion and protein phosphorylation in adrenal medullary cell culture. Proc. Natl. Acad. Sci. USA, 82: 930–934PubMedCrossRefGoogle Scholar
  90. Pogolotti A.L. and Santi D.V. (1982) High-pressure liquid chromatography-ultraviolet analysis of intracellular nucleotides. Anal. Biochem., 126: 335–345PubMedCrossRefGoogle Scholar
  91. Pointer RH., Butcher FR and Fain J.N. (1976) Studies on the role of cyclic guanosine 3, 5-monophosphate and extracellular Ca2+ in the regulation of glycogenesis in rat liver cells. J. Biol. Chem., 251: 2987–2992PubMedGoogle Scholar
  92. Prentki M., Wollheim C.B. and Lew P.D. (1984) Ca2+ homeostasis in permeabilized human neutrophils. J. Biol. Chem., 259: 13777–13782PubMedGoogle Scholar
  93. Ritchie D.M., Sierchio J.N., Bishop C.M., Hedli C.C., Levinson S.L. and Capetola RJ. (1984) Evaluation of calcium entry blockers in several models of immediate hypersensitivity. J. Pharmacol. Exp. Ther., 229: 690–695PubMedGoogle Scholar
  94. Spat A., Fabiat A. and Rubin RP. (1986) Binding of inositol trisphosphate by a liver microsomal fraction. Biochem. J., 233: 929–932PubMedGoogle Scholar
  95. Spearman T.N. and Butcher F.R (1983) The effect of calmodulin antagonists on amylase release from the rat parotid gland in vitro. Pjlugers Arch., 397: 220–224CrossRefGoogle Scholar
  96. Sullivan T.J., Parker KL., Eisen S.A. and Parker C.W. (1975) Modulation of cyclic AMP in purified rat mast cells. II. Studies on the relationship between intracellular cyclic AMP concentrations and histamine release. J. Immunol., 114: 1480–1485PubMedGoogle Scholar
  97. Tanaka T. and Hidaka H. (1980) Hydrophobic regions function in calmodulin-enzyme(s) interactions. J. Biol. Chem., 255: 11078–11080PubMedGoogle Scholar
  98. Tasaka K (1986) Anti-allergic drugs. Drugs Today, 22: 101–133Google Scholar
  99. Tasaka K, Mio M. and Okamoto M. (1986a) Intracellular calcium release induced by histamine releasers and its inhibition by some antiallergic drugs. Ann. Allergy, 56: 464–469PubMedGoogle Scholar
  100. Tasaka K, Mio M. and Okamoto M. (1986b) Changes in intracellular Ca2+ distribution of rat peritoneal mast cells before and after histamine release. Agents Actions, 18: 61–64PubMedCrossRefGoogle Scholar
  101. Tasaka K, Akagi M. and Miyoshi K (1986c) Distribution of actin filaments in rat mast cells and its role in histamine release. Agents Actions, 18: 49–52PubMedCrossRefGoogle Scholar
  102. Tasaka K, Akagi M., Mio M., Miyoshi K and Nakaya N. (1987a) Inhibitory effect of oxatomide on intracellular Ca mobilization, Ca uptake and histamine release, using rat peritoneal mast cells. Int. Arch. Allergy Appl. Immunol., 83: 348–353PubMedCrossRefGoogle Scholar
  103. Tasaka K, Mio M. and Okamoto M. (1987b) The role of intracellular Ca2+ in the degranulation of skinned mast cells. Agents Actions, 20: 157–160PubMedCrossRefGoogle Scholar
  104. Tasaka K, Akagi M., Miyoshi K and Mio M. (1988) Role of microfilaments in the exocytosis of rat peritoneal mast cells. Int. Arch. Allergy Appl. Immunol., 87: 213–221PubMedCrossRefGoogle Scholar
  105. Tasaka K and Mio M. (1989) Microfilament-associated degranulation of sensitized guinea-pig lung mast cells. Agents Actions, 27: 79–82PubMedCrossRefGoogle Scholar
  106. Tasaka K, Sugimoto Y. and Mio M. (1990) Sequential analysis of histamine release and intracellular Ca2+ release from murine mast cells. Int. Arch. Allergy Appl. Immunol., 91: 211–213PubMedCrossRefGoogle Scholar
  107. Tasaka K, Mio M., Fujisawa K and Aoki I. (1991) Role of microtubules on Ca2+ release from the endoplasmic reticulum and associated histamine release from rat peritoneal mast cells. Biochem. Pharmacol., 14: 1031–1037Google Scholar
  108. Tatham P.E.R. and Gomperts B.D. (1989) ATP inhibits onset of exocytosis in permeabilized mast cells. Biosci. Rep., 9: 99–109PubMedCrossRefGoogle Scholar
  109. Tsein R.Y., Pozzan T. and Rink T.J. (1982) Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with anew, intracellularly trapped fluorescence indicator. J. Cell Biol., 94: 325–334CrossRefGoogle Scholar
  110. Wakelam M.J.O., Davies S.A., Houslay M.D., McKay I., Marshall C.J. and Hall A. (1986) Normal p21(N-ras) couples bombesin and other growth factor receptors to inositol phosphate production. Nature, 322: 173–176CrossRefGoogle Scholar
  111. Wang P., Nishihata J., Takabori E., Yamamoto K, Toyoshima S. and Osawa T. (1989) Purification and partial amino acid sequences of a phospholipase C-associated GTP-binding protein from calf thymocytes. J. Biochem., 105: 461–466PubMedGoogle Scholar
  112. Wang T., Tsei L.I., Solaro J., Frassi de Gende A.O. and Schwartz A. (1979) Effects of potassium on vanadate inhibition of sarcoplasmic reticulum Ca2+ -ATPase from dog cardiac and rabbit skeletal muscle. Biochem. Biophys. Res. Commun., 91: 356–361PubMedCrossRefGoogle Scholar
  113. Watson S.P., McConell R.T. and Lapetina E.G. (1984) The rapid formation of inositol phosphates in human platelets by thrombin is inhibited by prostacyclin. J. Biol. Chem., 259: 13199–13203PubMedGoogle Scholar
  114. Weiss G.B. (1974) Cellular pharmacology of lanthanum. Ann. Rev. Pharmacol., 14: 343–354CrossRefGoogle Scholar
  115. White J.R., Ishizaka T., Ishizaka K and Sha’afi R.I. (1984) Direct demonstration of increased intracellular concentration of free calcium as measured by quin-2 in stimulated rat peritoneal mast cell. Proc. Natl. Acad. Sci. USA, 81: 3978–3982PubMedCrossRefGoogle Scholar
  116. White J.R., Pluznik D.H., Ishizaka K and Ishizaka T. (1985) Antigen-induced increase in protein kinase C activity in plasma membrane of mast cells. Proc. Natl. Acad. Sci. USA, 82: 8193–8197PubMedCrossRefGoogle Scholar
  117. White KN. and Metzger H. (1988) Translocation of protein kinase C in rat basophilic leukemic cells induced by phorbol ester or by aggregation of IgE receptors. J. Immunol., 141: 942–947PubMedGoogle Scholar
  118. Wick S.M. and Hepler P.K (1982) Selective localization of intracellular Ca2+ with potassium antimonate. J. Histochem. Cytochem., 30: 1190–1204PubMedCrossRefGoogle Scholar
  119. Wilson S.P. and Kirshner N. (1983) Calcium-evoked secretion from digitonin-permeabilized adrenal medullary chromaffin cells. J. Biol. Chem., 258: 4994–5000PubMedGoogle Scholar
  120. Wolf B.A., Florholmen J., Colca J.R. and McDaniel M.L. (1987) GTP mobilization of Ca2+ from the endoplasmic reticulum of islets. Biochem. J., 242: 137–141PubMedGoogle Scholar
  121. Yamamoto T., Kaibuchi K., Mizuno T., Hiroyoshi M., Shirataki H. and Takai Y. (1990) Purification and characterization from bovine brain cytosol of proteins that regulate the GDP/GTP exchange reaction of smg p21s, ras p21-like GTP-binding proteins. J. Biol. Chem., 265: 16626–16634PubMedGoogle Scholar
  122. Yoshii N., Mio M. and Tasaka K. (1988) Ca uptake and Ca releasing properties of the endoplasmic reticulum in rat peritoneal mast cells. Immunopharmacology, 16: 107–113PubMedCrossRefGoogle Scholar
  123. Yoshii N., Mio M., Akagi M. and Tasaka K. (1991) Role of endoplasmic reticulum, an intracellular Ca2+ store, in histamine release from rat peritoneal mast cell. Immunopharmacology, 21: 13–22PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1994

Authors and Affiliations

  • Kenji Tasaka
    • 1
  1. 1.The Department of Pharmacology in the Faculty of Pharmaceutical SciencesOkayama UniversityOkayamaJapan

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