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Role of Ca2+ and cAMP in histamine release from mast cells

  • Kenji Tasaka

Abstract

It is well known that an increase in intracellular Ca2+ concentrations and subsequent activation of Ca2+ -dependent pathways, such as calmodulin, protein kinase C and cytoskeletons, are prerequisite for the histamine release from mast cells. On the other hand, an increase in intracellular concentrations of cAMP is effective in inhibiting the histamine release from mast cells. Many antiallergic drugs have been developed based on this consequence either to inhibit the increase in intracellular Ca2+ level or to increase intracellular cAMP concentrations of mast cells. In this chapter, the roles of Ca2+ and cAMP in the histamine release from mast cells are reviewed.

Keywords

Mast Cell Histamine Release Dantrolene Sodium Induce Histamine Release Inhibit Histamine Release 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1994

Authors and Affiliations

  • Kenji Tasaka
    • 1
  1. 1.The Department of Pharmacology in the Faculty of Pharmaceutical SciencesOkayama UniversityOkayamaJapan

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