Advertisement

Role of brain histamine on corticosteroid release

  • Kenji Tasaka

Abstract

There is a considerable amount of literature that described how parenteral injection of histamine stimulates adrenocortical secretion in dogs and rats (Katsuki et al., 1967; Hirose et al., 1976; Cowan, 1975; Reilly, 1984), but few experiments have been done to clarify the role of brain histamine in releasing corticosteroids. Parenteral administration of histamine induces some side effects such as hypotensive effect and algesia, and these responses undoubtedly exert some influence on the pituitary-adrenocortical axis and adrenal steroid release. Since histamine does not enter into the brain through the blood-brain barrier, intracerebroventricular (i.c.v.) injection has been commonly employed to study the histamine effect on the central nervous system (CNS) (Feldberg and Sherwood, 1954; Tasaka et al., 1989). Rudolph et al. (1979) reported that activation of central H1 receptors increases ACTH secretion in dogs, and that activation of central H2 receptors decreases ACTH secretion. On the contrary, in rats, Bugajski and Gadek (1983) reported that i.c.v. injection of histamine increased plasma.corticosterone concentrations and this effect was mediated by both H1 and H2 receptors. From these findings, it seems likely that species difference exists between dogs and rats in histamine-induced corticosteroid release especially in the participation of H2 receptors. Recently, the presence of the H3 receptors, which is responsible for the feedback control of histamine synthesis and release, has also been demonstrated (Arrang et al., 1987). However, it is not known whether or not the H3 receptor is involved in histamine-induced steroidogenesis.

Keywords

Plasma ACTH ACTH Secretion Corticosterone Concentration Posterior Hypothalamus Plasma Cortisol Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Arrang, J.-M., Garbarg, M. and Schwartz, J.-C.: Autoinhibition of histamine synthesis mediated by presynaptic H3-receptors. Neuroscience, 23, 149–157 (1987)PubMedCrossRefGoogle Scholar
  2. Bugajski, J. and Gadek, A.: Central H1- and H2-histaminergic stimulation of pituitaryadrenocortical response under stress in rats. Neuroendocrinology, 36, 424–430 (1983)PubMedCrossRefGoogle Scholar
  3. Bugajski, J. and Gadek, A.: The effect of adrenergic and cholinergic antagonists on central histaminergic stimulation of pituitary-adrenocortical response under stress in rats. Neuroendocrinology, 38, 447–452 (1984)PubMedCrossRefGoogle Scholar
  4. Cohen, H., Graff, M. and Kleinberg, W.: Inhibition of dextran edema by proteolytic enzymes. Proc. Soc. expo Biol. Med., 88, 517–519 (1955)Google Scholar
  5. Cowan, J.S.: Adrenocorticotropin secretion rates following histamine injection in adult and newborn dogs. Can. J. Physiol. Pharmacol., 53, 592–602 (1975)PubMedCrossRefGoogle Scholar
  6. Feldberg, W. and Sherwood, S.L.: Injections of drugs into the lateral ventricle of the cat. J. Physiol., 123, 148–167 (1954)PubMedGoogle Scholar
  7. Ganong, W.F., Kramer, N., Salmon, J., Reid, LA., Lovinger, R., Scapagnini, D., Boryczka, A.T. and Shackelford, R.: Pharmacological evidence for inhibition of ACTH secretion by a central adrenergic system in the dog. Neuroscience, 1, 167–174 (1976)PubMedCrossRefGoogle Scholar
  8. Halász, B. and Szentágothai, J.: Histologischer Beweis einer nervösen signalübermittiung von der Nebennierenrinde zum Hypothalamus. Z. Zellforsch., 50, 297–306 (1959)PubMedCrossRefGoogle Scholar
  9. Hirose, T., Matsumoto, L and Suzuki, T.: Adrenal cortical secretory responses to histamine and cyanide in dogs with hypothalamic lesions. Neuroendocrinology, 21, 304–311 (1976)PubMedCrossRefGoogle Scholar
  10. Hirose, T., Matsumoto, L and Aikawa, T.: Direct effect of histamine on cortisol and cor ticosterone production by isolated dog adrenal cells. J. Endocrinol., 76, 369–370 (1978)CrossRefGoogle Scholar
  11. Holzwarth, M.A., Cunningham, L.A. and Kleitman, N.: The role of adrenal nerves in the regulation of adrenocortical functions. Ann. N.Y. Acad. Sci. U.S.A., 512, 449–464 (1987)CrossRefGoogle Scholar
  12. Itowi, N., Yamatodani, A., Cacabelos, R., Goto, M. and Wada, H.: Effect of histamine depletion on circadian variations of corticotropin and corticosterone in rats. Neuroendocrinology, 50, 187–192 (1989)PubMedCrossRefGoogle Scholar
  13. Kamei, C., Okumura, Y., Tsujimoto, S. and Tasaka, K: Role of hypothalamic histamine in stimulating the corticosterone release in rats. Arch. into Pharmacodyn., 325, 35–50 (1993)Google Scholar
  14. Karppanen, H., Paakkari, I., Paakkari, P., Huotari, R. and Onna, A.-L.: Possible involvement of central histamine H2-receptors in the hypotensive effect of clonidine. Nature, 259, 587–588 (1976)PubMedCrossRefGoogle Scholar
  15. Katsuki, S., Ito, M., Watanabe, A., Iino, K, Yuji, S. and Kondo, S.: Effect of hypothalamic lesions on pituitary-adrenocortical responses to histamine and methopyrapone. Endocrinology, 81, 941–945 (1967)PubMedCrossRefGoogle Scholar
  16. Kemppainen, R.J., Filer, D.V., Sartin, J.L. and Reed, R.B.: Ovine corticotrophin-releasing factor in dogs: Dose-response relationships and effects of dexamethasone. Acta Endocrinol., 112, 12–19 (1986)PubMedGoogle Scholar
  17. Kollonitsch, J., Patchett, A.A., Marburg, S., Maycock, A.L., Perkins, L.M., Doldouras, G.A., Duggan, D.E. and Aster, S.D.: Selective inhibitors of biosynthesis of aminergic neurotransmitters. Nature, 274, 906–908 (1978)PubMedCrossRefGoogle Scholar
  18. Maki, K, Takahashi, H., Kakimoto, M., Nakajima, M. and Tasaka, K: Anti-inflammatory mechanism of Prozime-10, a proteolytic enzyme. Pharmacology, 23, 230–236 (1981)PubMedCrossRefGoogle Scholar
  19. Martin, G.J., Brendel, R. and Beiler, J.M.: Inhibition of egg-white edema by proteolytic enzymes. Proc. Soc. expo Biol. Med., 86, 636–638 (1954)Google Scholar
  20. Mazurkiewicz-Kwilecki, I.M.: Brain histamine-plasma corticosterone interactions. Life Sci., 32, 1099–1106 (1983)PubMedCrossRefGoogle Scholar
  21. Miechowski, W.L. and Ercoli, N.: Studies on proteolytic enzymes. II. Trypsin and chymotrypsin in relation to inflammatory processes. J Pharmacol. Exp. Ther., 116, 43–44 (1956)Google Scholar
  22. Morita, Y. and Koyama, K: Histamine-induced ACTH secretion and inhibitory effect of antihistaminic drugs. Japan. J. Pharmacol., 29, 59–65 (1979)CrossRefGoogle Scholar
  23. Panula, P., Yang, H.-Y.T. and Costa, E.: Histamine-containing neurons in the rat hypothalamus. Proc. Natl. Acad. Sci. U.S.A., 81, 2572–2576 (1984)PubMedCrossRefGoogle Scholar
  24. Paxinos, G. and Watson, C.: The rat brain in stereotaxic coordinates. Academic Press, San Diego, 1986Google Scholar
  25. Redgate, E.S. and Fahringer, E.E.: A comparison of the pituitary adrenal activity elicited by electrical stimulation of preoptic, amygdaloid and hypothalamic sites in the rat brain. Neuroendocrinology, 12, 334–343 (1973)PubMedCrossRefGoogle Scholar
  26. Reilly, M.A.: Biogenic amine participation in histamine stimulation of ACTH release. Agents Actions, 14, 630–632 (1984)CrossRefGoogle Scholar
  27. Rudolph, C., Richards, G.E., Kaplan, S. and Ganong, W.F.: Effect of intraventricular histamine on hormone secretion in dogs. Neuroendocrinology, 29, 169–177 (1979)PubMedCrossRefGoogle Scholar
  28. Seltzer, A.M., Donoso, A.O. and Podesta, E.: Restraint stress stimulation of prolactin and ACTH secretion: Role of brain histamine. Physiol. Behav., 36, 251–255 (1986)PubMedCrossRefGoogle Scholar
  29. Saper, C.B., Loewy, A.D., Swanson, L.W. and Cowan, W.M.: Direct hypothalamoautonomic connections. Brain Res., 117, 305–312 (1976)PubMedCrossRefGoogle Scholar
  30. Schürmeyer, T.H., Gold, P.W., Gallucci, W.T., Tomai, T.P., Cutler, G.B. Jr., Loriaux, D.L. and Chrousos, G.P.: Effects and pharmacokinetic properties of the rat/human corticotropin-releasing factor in rhesus monkeys. Endocrinology, 117, 300–306 (1985)PubMedCrossRefGoogle Scholar
  31. Tasaka, K., Meshi, T., Akagi, M., Kakimoto, M., Saito, R., Okada, I. and Maki, K.: Anti-inflammatory activity of a proteolytic enzyme, Prozime-10. Pharmacology, 21, 43–52 (1980)PubMedCrossRefGoogle Scholar
  32. Tasaka, K., Chung, Y.H., Sawada, K. and Mio, M.: Excitatory effect of histamine on the arousal system and its inhibition by H1 blockers. Brain Res. Bull., 22, 271–275 (1989)PubMedCrossRefGoogle Scholar
  33. Tsujimoto, S., Kamei, C., Yoshida, T. and Tasaka, K.: Changes in plasma adrenocorticotropic hormone and cortisol levels induced by intracerebroventricular injection of histamine and its related compounds in dogs. Pharmacology, 47, 73–83 (1993a).PubMedCrossRefGoogle Scholar
  34. Tsujimoto, S., Okumura, Y., Kamei, C. and Tasaka, K.: Effects of intracerebroventricular injection of histamine and related compounds on corticosterone release in rats. Br. J. Pharmacol., 109, 807–813 (1993b)PubMedGoogle Scholar
  35. Unsicker, K.: On the innervation of the rat and pig adrenal cortex. Z. Zellforsch., 116, 151–156 (1971)PubMedCrossRefGoogle Scholar
  36. Yoshida, T., Mio, M. and Tasaka, K.: Cortisol secretion induced by substance P from bovine adrenocortical cells and its inhibition by calmodulin inhibitors. Biochem. Pharmacol., 43, 513–517 (1992)PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1994

Authors and Affiliations

  • Kenji Tasaka
    • 1
  1. 1.The Department of Pharmacology in the Faculty of Pharmaceutical SciencesOkayama UniversityOkayamaJapan

Personalised recommendations