Abstract
There is a considerable amount of literature that described how parenteral injection of histamine stimulates adrenocortical secretion in dogs and rats (Katsuki et al., 1967; Hirose et al., 1976; Cowan, 1975; Reilly, 1984), but few experiments have been done to clarify the role of brain histamine in releasing corticosteroids. Parenteral administration of histamine induces some side effects such as hypotensive effect and algesia, and these responses undoubtedly exert some influence on the pituitary-adrenocortical axis and adrenal steroid release. Since histamine does not enter into the brain through the blood-brain barrier, intracerebroventricular (i.c.v.) injection has been commonly employed to study the histamine effect on the central nervous system (CNS) (Feldberg and Sherwood, 1954; Tasaka et al., 1989). Rudolph et al. (1979) reported that activation of central H1 receptors increases ACTH secretion in dogs, and that activation of central H2 receptors decreases ACTH secretion. On the contrary, in rats, Bugajski and Gadek (1983) reported that i.c.v. injection of histamine increased plasma.corticosterone concentrations and this effect was mediated by both H1 and H2 receptors. From these findings, it seems likely that species difference exists between dogs and rats in histamine-induced corticosteroid release especially in the participation of H2 receptors. Recently, the presence of the H3 receptors, which is responsible for the feedback control of histamine synthesis and release, has also been demonstrated (Arrang et al., 1987). However, it is not known whether or not the H3 receptor is involved in histamine-induced steroidogenesis.
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References
Arrang, J.-M., Garbarg, M. and Schwartz, J.-C.: Autoinhibition of histamine synthesis mediated by presynaptic H3-receptors. Neuroscience, 23, 149–157 (1987)
Bugajski, J. and Gadek, A.: Central H1- and H2-histaminergic stimulation of pituitaryadrenocortical response under stress in rats. Neuroendocrinology, 36, 424–430 (1983)
Bugajski, J. and Gadek, A.: The effect of adrenergic and cholinergic antagonists on central histaminergic stimulation of pituitary-adrenocortical response under stress in rats. Neuroendocrinology, 38, 447–452 (1984)
Cohen, H., Graff, M. and Kleinberg, W.: Inhibition of dextran edema by proteolytic enzymes. Proc. Soc. expo Biol. Med., 88, 517–519 (1955)
Cowan, J.S.: Adrenocorticotropin secretion rates following histamine injection in adult and newborn dogs. Can. J. Physiol. Pharmacol., 53, 592–602 (1975)
Feldberg, W. and Sherwood, S.L.: Injections of drugs into the lateral ventricle of the cat. J. Physiol., 123, 148–167 (1954)
Ganong, W.F., Kramer, N., Salmon, J., Reid, LA., Lovinger, R., Scapagnini, D., Boryczka, A.T. and Shackelford, R.: Pharmacological evidence for inhibition of ACTH secretion by a central adrenergic system in the dog. Neuroscience, 1, 167–174 (1976)
Halász, B. and Szentágothai, J.: Histologischer Beweis einer nervösen signalübermittiung von der Nebennierenrinde zum Hypothalamus. Z. Zellforsch., 50, 297–306 (1959)
Hirose, T., Matsumoto, L and Suzuki, T.: Adrenal cortical secretory responses to histamine and cyanide in dogs with hypothalamic lesions. Neuroendocrinology, 21, 304–311 (1976)
Hirose, T., Matsumoto, L and Aikawa, T.: Direct effect of histamine on cortisol and cor ticosterone production by isolated dog adrenal cells. J. Endocrinol., 76, 369–370 (1978)
Holzwarth, M.A., Cunningham, L.A. and Kleitman, N.: The role of adrenal nerves in the regulation of adrenocortical functions. Ann. N.Y. Acad. Sci. U.S.A., 512, 449–464 (1987)
Itowi, N., Yamatodani, A., Cacabelos, R., Goto, M. and Wada, H.: Effect of histamine depletion on circadian variations of corticotropin and corticosterone in rats. Neuroendocrinology, 50, 187–192 (1989)
Kamei, C., Okumura, Y., Tsujimoto, S. and Tasaka, K: Role of hypothalamic histamine in stimulating the corticosterone release in rats. Arch. into Pharmacodyn., 325, 35–50 (1993)
Karppanen, H., Paakkari, I., Paakkari, P., Huotari, R. and Onna, A.-L.: Possible involvement of central histamine H2-receptors in the hypotensive effect of clonidine. Nature, 259, 587–588 (1976)
Katsuki, S., Ito, M., Watanabe, A., Iino, K, Yuji, S. and Kondo, S.: Effect of hypothalamic lesions on pituitary-adrenocortical responses to histamine and methopyrapone. Endocrinology, 81, 941–945 (1967)
Kemppainen, R.J., Filer, D.V., Sartin, J.L. and Reed, R.B.: Ovine corticotrophin-releasing factor in dogs: Dose-response relationships and effects of dexamethasone. Acta Endocrinol., 112, 12–19 (1986)
Kollonitsch, J., Patchett, A.A., Marburg, S., Maycock, A.L., Perkins, L.M., Doldouras, G.A., Duggan, D.E. and Aster, S.D.: Selective inhibitors of biosynthesis of aminergic neurotransmitters. Nature, 274, 906–908 (1978)
Maki, K, Takahashi, H., Kakimoto, M., Nakajima, M. and Tasaka, K: Anti-inflammatory mechanism of Prozime-10, a proteolytic enzyme. Pharmacology, 23, 230–236 (1981)
Martin, G.J., Brendel, R. and Beiler, J.M.: Inhibition of egg-white edema by proteolytic enzymes. Proc. Soc. expo Biol. Med., 86, 636–638 (1954)
Mazurkiewicz-Kwilecki, I.M.: Brain histamine-plasma corticosterone interactions. Life Sci., 32, 1099–1106 (1983)
Miechowski, W.L. and Ercoli, N.: Studies on proteolytic enzymes. II. Trypsin and chymotrypsin in relation to inflammatory processes. J Pharmacol. Exp. Ther., 116, 43–44 (1956)
Morita, Y. and Koyama, K: Histamine-induced ACTH secretion and inhibitory effect of antihistaminic drugs. Japan. J. Pharmacol., 29, 59–65 (1979)
Panula, P., Yang, H.-Y.T. and Costa, E.: Histamine-containing neurons in the rat hypothalamus. Proc. Natl. Acad. Sci. U.S.A., 81, 2572–2576 (1984)
Paxinos, G. and Watson, C.: The rat brain in stereotaxic coordinates. Academic Press, San Diego, 1986
Redgate, E.S. and Fahringer, E.E.: A comparison of the pituitary adrenal activity elicited by electrical stimulation of preoptic, amygdaloid and hypothalamic sites in the rat brain. Neuroendocrinology, 12, 334–343 (1973)
Reilly, M.A.: Biogenic amine participation in histamine stimulation of ACTH release. Agents Actions, 14, 630–632 (1984)
Rudolph, C., Richards, G.E., Kaplan, S. and Ganong, W.F.: Effect of intraventricular histamine on hormone secretion in dogs. Neuroendocrinology, 29, 169–177 (1979)
Seltzer, A.M., Donoso, A.O. and Podesta, E.: Restraint stress stimulation of prolactin and ACTH secretion: Role of brain histamine. Physiol. Behav., 36, 251–255 (1986)
Saper, C.B., Loewy, A.D., Swanson, L.W. and Cowan, W.M.: Direct hypothalamoautonomic connections. Brain Res., 117, 305–312 (1976)
Schürmeyer, T.H., Gold, P.W., Gallucci, W.T., Tomai, T.P., Cutler, G.B. Jr., Loriaux, D.L. and Chrousos, G.P.: Effects and pharmacokinetic properties of the rat/human corticotropin-releasing factor in rhesus monkeys. Endocrinology, 117, 300–306 (1985)
Tasaka, K., Meshi, T., Akagi, M., Kakimoto, M., Saito, R., Okada, I. and Maki, K.: Anti-inflammatory activity of a proteolytic enzyme, Prozime-10. Pharmacology, 21, 43–52 (1980)
Tasaka, K., Chung, Y.H., Sawada, K. and Mio, M.: Excitatory effect of histamine on the arousal system and its inhibition by H1 blockers. Brain Res. Bull., 22, 271–275 (1989)
Tsujimoto, S., Kamei, C., Yoshida, T. and Tasaka, K.: Changes in plasma adrenocorticotropic hormone and cortisol levels induced by intracerebroventricular injection of histamine and its related compounds in dogs. Pharmacology, 47, 73–83 (1993a).
Tsujimoto, S., Okumura, Y., Kamei, C. and Tasaka, K.: Effects of intracerebroventricular injection of histamine and related compounds on corticosterone release in rats. Br. J. Pharmacol., 109, 807–813 (1993b)
Unsicker, K.: On the innervation of the rat and pig adrenal cortex. Z. Zellforsch., 116, 151–156 (1971)
Yoshida, T., Mio, M. and Tasaka, K.: Cortisol secretion induced by substance P from bovine adrenocortical cells and its inhibition by calmodulin inhibitors. Biochem. Pharmacol., 43, 513–517 (1992)
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© 1994 Springer-Verlag Tokyo
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Tasaka, K. (1994). Role of brain histamine on corticosteroid release. In: New Advances in Histamine Research. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68263-9_3
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DOI: https://doi.org/10.1007/978-4-431-68263-9_3
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