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Excitatory effect of histamine on the arousal system

  • Kenji Tasaka

Abstract

It has been reported that histamine appears to act as a neurotransmitter in the mammalian brain (Schwartz, 1975). In 1954, Feldberg and Sherwood demonstrated that intracerebroventricular (i.c.v.) injection of histamine (200 μg) elicited a decrease in spontaneous activity and sleepiness in cats. In mice and rats, it was also found that high doses of histamine (i.c. v., 20–100 μg) produced sedation, ptosis and drowsy patterns in spontaneous EEGs characterized by high amplitude and low frequency EEG waves (Kamei et al., 1981). Moreover, i.c.v. injection of histamine (at doses of μg or more) elicited an inhibition of the pinna reflex (Kamei et al., 1984) as well as a prolongation of thiopental sleeping time in mice (Kamei et al., 1986). These findings seem to suggest that high doses of histamine exerts an inhibitory influence on the central nervous system (CNS). By contrast, Monnier et al. (1970, 1977) reported that intravenous (i.v.) and i.c.v. injection of histamine induced an EEG arousal response characterized by decreased delta activity in the cerebral cortex. It has also been shown that histamine (250 ng) induced a significant increase in spontaneous motor activity in the conscious rat, including increased grooming and exploratory behavior, indicating that histamine may be involved in modulating behavioral arousal (Kalivas, 1982). In accordance with this view, H1 antagonists have caused drowsy patterns in spontaneous EEGs and sedative effects in humans (Carruthers et al., 1978) and experimental animals (Heinrich, 1953; Tasaka et al., 1986)

Keywords

Electrical Stimulation Arousal Effect Spontaneous Motor Activity Histamine Content Delta Wave 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1994

Authors and Affiliations

  • Kenji Tasaka
    • 1
  1. 1.The Department of Pharmacology in the Faculty of Pharmaceutical SciencesOkayama UniversityOkayamaJapan

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