Skip to main content
SpringerLink
Log in

Molecular and Serological Characteristics of Hepatitis E Virus

  • Conference paper
Viral Hepatitis and Liver Disease

Abstract

The molecular and serological features of hepatitis E virus (HEV) are briefly described. The organization of the genome is discussed and compared to those of other closely and distantly related viruses that contain single-stranded, positive-sense RNA genomes. Based on physiochemical properties, HEV has been loosely associated with caliciviruses and tentatively assigned to the family Caliciviridae, although it possesses unique genetic features not found in any other calicivirus.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bradley DW (1990) Hepatitis non-A, non-B viruses become identified as hepatitis C and E viruses. In: Melnick JL (ed) Progress in medical virology, vol 37. Karger AG, Basel, pp 101–135

    Google Scholar 

  2. Bradley DW (1990) Enterically-transmitted non-A, non-B hepatitis. Br Med Bull 46: 442–461

    PubMed  CAS  Google Scholar 

  3. Bradley DW, Krawczynski K, Beach MJ, Purdy MA (1991) Non-A, non-B hepatitis: Toward the discovery of hepatitis C and E viruses. Semin Liver Dis 11: 128–146

    Article  PubMed  CAS  Google Scholar 

  4. Bradley DW, Andjaparidze A, Cook EH, McCaustland K, Balayan M, Stetler H, Velazquez O, Robertson B, Humphrey C, Kane M, Weisfuse I (1988) Aetiological agent of enterically-transmitted non-A, non-B hepatitis. J Gen Virol 69: 731–738

    Article  PubMed  CAS  Google Scholar 

  5. Reyes GR, Purdy MA, Kim JP, Luk K-C, Young LM, Frey KE, Bradley DW (1990) Isolation of a cDNA from the virus responsible for enterically transmitted non-A, non-B hepatitis. Science 247: 1335–1339

    Article  PubMed  CAS  Google Scholar 

  6. Reyes GR, Kim JP (1991) Sequence-independent, single-primer amplification ( SISPA) of complex DNA populations. Mol Cell Probes 5: 473–481

    Article  PubMed  CAS  Google Scholar 

  7. Tam AW, Smith MM, Guerra ME, Huang CC, Bradley DW, Fry KF, Reyes GR (1991) Hepatitis E virus (HEV): Molecular cloning and sequencing of the full-length viral genome. Virology 185: 120–131

    Article  PubMed  CAS  Google Scholar 

  8. Fry KE, Tam AW, Smith MM, Kim JP, Luk K-C, Young LM, Paatak M, Feldman RA, Yun KY, Purdy MA, McCaustland KA, Bradley DW, Reyes GR (1991) Hepatitis E virus (HEV): Strain variation in the nonstructural gene region encoding motifs for an RNA-dependent RNA polymerase and an ATP/GTP binding site. Virus Genes 6: 173–185

    Article  Google Scholar 

  9. Koonin EV, Gorbalenya AE, Purdy MA, Rozanov MN, Reyes GR, Bradley DW (1992) Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: Delineation of an additional group of positive-strand RNA plant and animal viruses. Proc Nat Acad Sci USA 89: 8259–8263

    Article  PubMed  CAS  Google Scholar 

  10. Jiang X, Graham DY, Wang K, Estes MK (1990) Norwalk virus genome cloning and characterization. Science 250: 1580–1583

    Article  CAS  Google Scholar 

  11. Tohya Y, Taniguchi Y, Utagawa E, Takeda N, Miyamura K, Yamazaki S, Mikami T (1991) Sequence analysis of the 3′ end of feline calicivirus genome. Virology 183: 810–814

    Article  PubMed  CAS  Google Scholar 

  12. Purdy MA, McCaustland KA, Krawczynski K, Tarn A, Beach MJ, Tassopoulos NC, Reyes GR, Bradley DW (1992) Expression of a hepatitis E virus (HEV)-trpE fusion protein containing epitopes recognized by antibodies in sera from human cases and experimentally infected primates. Arch Virol 123: 335–349

    Article  PubMed  CAS  Google Scholar 

  13. Purdy MA, McCaustland KA, Krawczynski K, Spelbring J, Reyes GR, Bradley DW (1993) Preliminary report of a trpE-HEV fusion protein that protects cynomolgus macaques against challenge with wild–type HEV. J Med Virol 41: 90–94

    Article  PubMed  CAS  Google Scholar 

  14. Kaur M, Hyams KC, Purdy MA, Krawczynski K, Ching WM, Fry KE, Reyes GR, Bradley DW, Carl M (1992) Human linear B-cell epitopes encoded by the hepatitis E virus include determinants in the RNA-dependent RNA polymerase. Proc Nat Acad Sci USA 89: 3855–3858

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control, Mailstop A33, 1600 Clifton Road, N.E., Atlanta, GA, 30333, USA

    Daniel W. Bradley Ph.D. & Michael A. Purdy

Authors
  1. Daniel W. Bradley Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michael A. Purdy
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Japanese Red Cross, Tokyo, Japan

    K. Nishioka M.D. (Chairman of 1993 ISVHLD) (Chairman of 1993 ISVHLD)

  2. Yamanashi Medical College, Yamanashi, Japan

    H. Suzuki (Vice Chairman of 1993 ISVHLD) (Vice Chairman of 1993 ISVHLD)

  3. Institute of Immunology, Tokyo, Japan

    S. Mishiro (Committee Member of 1993 ISVHLD) (Committee Member of 1993 ISVHLD)

  4. Japanese Red Cross Medical Center, Tokyo, Japan

    T. Oda (Honorary Chairman of 1993 ISVHLD) (Honorary Chairman of 1993 ISVHLD)

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer-Verlag Tokyo

About this paper

Cite this paper

Bradley, D.W., Purdy, M.A. (1994). Molecular and Serological Characteristics of Hepatitis E Virus. In: Nishioka, K., Suzuki, H., Mishiro, S., Oda, T. (eds) Viral Hepatitis and Liver Disease. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68255-4_11

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-68255-4_11

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68257-8

  • Online ISBN: 978-4-431-68255-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation