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Adverse Effects of Regurgitant Duodenal Content on the Mucosa of the Residual Stomach After Partial Gastrectomy

  • Ryukichi Hada
  • Yasunori Mikami
  • Dai Seito
  • Yuzuru Sugiyama
  • Hidetoshi Suzuki
  • Mitsuru Konn
  • Masanori Ozawa
Conference paper

Abstract

Three groups of patients partially gastrectomized by Billroth II, Billroth I or pylorus-preserving procedure were evaluated for amount of bile acids in the gastric aspirate and histologic changes in the remnant gastric mucosa. The amount of bile acids was the highest and glandular dysplasia of the mucosa most predominant in the B-II group. Rats with either gastrojejunostomy or simple gastrotomy were maintained with an usual laboratory diet. Intestinal type adenoma and carcinoma developed exclusively in the gastrojejunostomized rats. Prolonged exposure of the gastric mucosa to bilious content may result in its histological changes that possibly lead to development of carcinoma.

Keywords

Bile Acid Total Bile Acid Tubular Adenocarcinoma Gastric Aspirate Bile Acid Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag Tokyo 1993

Authors and Affiliations

  • Ryukichi Hada
    • 1
  • Yasunori Mikami
    • 1
  • Dai Seito
    • 1
  • Yuzuru Sugiyama
    • 1
  • Hidetoshi Suzuki
    • 1
  • Mitsuru Konn
    • 1
  • Masanori Ozawa
    • 2
  1. 1.Department of SurgeryHirosaki University School of MedicineHirosaki 036Japan
  2. 2.Department of SurgeryHakodate Municipal HospitalHakodate, Hokkaido 040Japan

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