Adverse Effects of Regurgitant Duodenal Content on the Mucosa of the Residual Stomach After Partial Gastrectomy
Three groups of patients partially gastrectomized by Billroth II, Billroth I or pylorus-preserving procedure were evaluated for amount of bile acids in the gastric aspirate and histologic changes in the remnant gastric mucosa. The amount of bile acids was the highest and glandular dysplasia of the mucosa most predominant in the B-II group. Rats with either gastrojejunostomy or simple gastrotomy were maintained with an usual laboratory diet. Intestinal type adenoma and carcinoma developed exclusively in the gastrojejunostomized rats. Prolonged exposure of the gastric mucosa to bilious content may result in its histological changes that possibly lead to development of carcinoma.
KeywordsBile Acid Total Bile Acid Tubular Adenocarcinoma Gastric Aspirate Bile Acid Level
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