Advertisement

Radio-Immunoguided Surgery for Large Bowel Cancer

  • Ian C. Lavery
Conference paper

Abstract

The intra-operative detection of metastatic disease in colorectal cancer depends on tumor-associated antigen and antibodies a- well as detection technology. A hand-held gamma detecting probe is capable of detecting as few as 6×105 labelled cells in vitro.

In a multicentre phase 1-11 study using B72.3 with 1125 105 patients (26 primary, 72 recurrent, 6 no tumor) were enrolled. There was 78% localization - 24/32 primary tumors 126/199 recurrent sites. Occult tumor was detected in 30 sites in 26 patients. There was an impact on management in approximately 1/3 of recurrent cases.

Of 17 patients for complete excision of recurrent tumor, 10 had complete excision and 7 recurred in 1 year. Four with elevated CEA had no tumor found, 2 had widespread metastases (no resection), 1 had bilateral radio uptake and biopsy -negative tumor-free at 3 years.

A current Phase II study is being conducted using MoAle CC49 labelled with 1-2 Mci with primary tumor localization 86% and 97% in second look metastases.

Keywords

Primary Tumor Localization Large Bowel Cancer Occult Tumor Acute Hypersensitivity Reaction Current Colorectal Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Kohler G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256: 495–497PubMedCrossRefGoogle Scholar
  2. 2.
    Gold P, Freedman SI (1965) Demonstration of t-mor specific antigens in human colonic carcinomata by immunologican tolerance and absorption techniques. J Exp Med 121: 439–462PubMedCrossRefGoogle Scholar
  3. 3.
    Poste G, Doll J. Brown AE, et al. (1982) Comparison of the metastatic properties of B16 melanoma clones isolated from cultured cell lines subcutaneous tumors and individual lung metastases. Cancer Res 42: 277 0–2778PubMedGoogle Scholar
  4. 4.
    Herlyn D, Powe J, Alavi A, et al. (1983) Radioimmunodetection of human tumor xenografts by monoclonal antibodies. Cancer Res 43: 2731–2735PubMedGoogle Scholar
  5. 5.
    O’Connor SW, Blae WF (1984) Accessibility of circulating immunoglobin G to the extravascular compartment of solid rat tumors. Cancer Res 44: 3719–3723PubMedGoogle Scholar
  6. 6.
    Aitken DR, Hinkle GH, Thurston MO et al. (1984) A gamma detecting probe for radioimmune detection of CEA producing tumors: Successful experimental use and clinical case report. Dis Colon Rectum 27: 279–282PubMedCrossRefGoogle Scholar
  7. 7.
    Martin DT, Hinkle GH, Tuttle S, et al. (1985) Intraoperative radioimmunodetection of colorectal tumor with a hand-held radiation detector. Am J Surg 150: 672–675PubMedCrossRefGoogle Scholar
  8. 8.
    Thor A, Ohuchi N, Szpak CA, Johnston WW, Schlom J (1986) The distribution of oncofetal antigen TAG-72 defined by monoclonal antibody B72.3. Cancer Res 46: 3118–3124PubMedGoogle Scholar
  9. 9.
    Martin EW Jr., Mojzisik CM, Hinkle GH, et al. (1988) Radioimmunoguided surgery using monoclonal antibody. Am J Surg 156: 386–392PubMedCrossRefGoogle Scholar
  10. 10.
    Colcher D, Esteban JM, Carrosquillo JA et al. (1987) Quantitative analyses of selective radiolabelled monoclonal antibody localization in metastatic lesion of colorectal cancer patients. Cancer Research 47: 1185–1189PubMedGoogle Scholar
  11. 11.
    Schlom J, Colcher D, Roselli M, et al. (1988) Tumor targeting with monoclonal antibody B72.3. Nul Med Biol 16: 137–142Google Scholar
  12. 12.
    Sickle-Santanello BJ, O’Dwyer PJ, Mojzisik CM, et al. (1987) Radioimmunoguided surgery using the monoclonal antibody B72.3 in colorectal tumors. Dis Colon and Rectum 30: 761–764CrossRefGoogle Scholar
  13. 13.
    DeLand FH, Kim EE, Corgani RL, et al: Axillary lymphoscintigraphy by radioimmunodetection of carcinoembryonic antigen in breast cancer. J Nuc Med (1979) 20: 1243–1250Google Scholar
  14. 14.
    Thompson CH, Lichtenstein M, Stacker SA et al. (1984) Immunoscintigraphy for detection of lymph nodes metastases from breast cancer. Lancet 2: 1245–1247PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1993

Authors and Affiliations

  • Ian C. Lavery
    • 1
  1. 1.Cleveland Clinic FoundationClevelandUSA

Personalised recommendations