Local Immunotherapy for Gastric Cancer Using a Mixture of OK-432 and Fibrinogen
OK-432 is an immunomodulatory agent prepared from a strain of Streptococcus pyogenes. We have previously reported that OK-432 displays considerably enhanced antitumor activity when injected intratumorally together with fibrinogen . In the present study, we administered a mixture of OK-432 and fibrinogen (OK/fbg) into gastric carcinoma and examined the immune reactions induced in the tumors and in spleen.
KeywordsGastric Cancer Gastric Carcinoma Spleen Cell Immunomodulatory Agent Daudi Cell