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Local Immunotherapy for Gastric Cancer Using a Mixture of OK-432 and Fibrinogen

  • Taro Wakasugi
  • Tsutomu Takeda
  • Takushi Monden
  • Yoshihiro Katsumoto
  • Isao Sakita
  • Hirohito Nagaoka
  • Mutsumi Fukunaga
  • Takashi Shimano
  • Hitoshi Shiozaki
  • Takesada Mori
Conference paper

Abstract

OK-432 is an immunomodulatory agent prepared from a strain of Streptococcus pyogenes. We have previously reported that OK-432 displays considerably enhanced antitumor activity when injected intratumorally together with fibrinogen [1]. In the present study, we administered a mixture of OK-432 and fibrinogen (OK/fbg) into gastric carcinoma and examined the immune reactions induced in the tumors and in spleen.

Keywords

Gastric Cancer Gastric Carcinoma Spleen Cell Immunomodulatory Agent Daudi Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Monden T, Morimoto H, Shimano T, Yagyu T, Murotani M, Nagaoka H, Kawasaki Y, Kobayashi T, Mori T (1992) Use of Fibrinogen to Enhance the Antitumor Effect of OK-432. Cancer 69: 636–642PubMedCrossRefGoogle Scholar
  2. 2.
    Nagaoka H, Monden T, Sakita I, Katsumoto Y, Wakasugi T, Kawasaki Y, Tomita N, Takeda T, Yagyu T, Morimoto H, Kobayashi T, Shimano T, Mori T (1992) Establishment of cytotoxic CD4+T cell clones from cancer patients treated by local immunotherapy. Biotherapy 5: 241–250PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1993

Authors and Affiliations

  • Taro Wakasugi
    • 1
  • Tsutomu Takeda
    • 1
  • Takushi Monden
    • 1
  • Yoshihiro Katsumoto
    • 1
  • Isao Sakita
    • 1
  • Hirohito Nagaoka
    • 1
  • Mutsumi Fukunaga
    • 1
  • Takashi Shimano
    • 1
  • Hitoshi Shiozaki
    • 1
  • Takesada Mori
    • 1
  1. 1.Department of Surgery IIOsaka University Medical SchoolOsaka, 553Japan

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