Blood Velocity Profiles Along Poststenotic Coronary Artery and Stenotic Intramyocardial Flow

  • Fumihiko Kajiya
  • Osamu Hiramatsu
  • Akihiro Kimura
  • Masami Goto
  • Yasuo Ogasawara
  • Katsuhiko Tsujioka


To evaluate the effect of coronary stenosis on coronary flow, we evaluated: (1) the blood velocity profiles across the vessel at portions distal to stenosis, (2) the velocity waveform in the septal artery during left main coronary artery stenosis with or without vasodilators, and (3) transmural flow distribution with low perfusion pressure as in stenosis before and after intracoronary nitroglycerin. The experiments were performed in 29 dogs using our 80-channel 20 MHz ultrasound velocimeter. The poststenotic velocity configuration was characterized by a narrow region of high velocity with diastolic reverse flows near the wall which may dissipate energy. Septal artery blood flow velocity which reflected myocardial inflow showed a diastolic-predominant waveform always accompanied by a systolic retrograde blood velocity component. Coronary artery stenosis enhanced the systolic retrograde flow with a decrease in diastolic flow, reducing myocardial inflow. The systolic retrograde flow was augmented further by coronary vasodilation (intracoronary adenosine or nitroglycerin) and did not improve myocardial inflow (or decreased it). Intracoronary nitroglycerin increased epimyocardial flow, but did not increase endomyocardial flow. In conclusion, an augmented retrograde flow which is increased by vasodilators plays an important role in disturbing myocardial inflow during coronary artery stenosis. This could be called a “coronary slosh phenomenon”. Thus, increased systolic retrograde flow and the decreased diastolic flow are closely related in reducing myocardial flow, especially subendocardial flow.


Left Anterior Descend Coronary Artery Stenosis Blood Velocity Left Main Coronary Artery Velocity Waveform 
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  1. 1.
    Gould KL (1978) Pressure-flow characteristics of coronary stenosis in unsedated dogs at rest and during coronary vasodilation. Circ Res 43:242–253PubMedGoogle Scholar
  2. 2.
    Young DF, Tsai FY (1973) Flow characteristics in models of arterial stenosis: 1. Steady flow. J Biomech 6:395–410PubMedCrossRefGoogle Scholar
  3. 3.
    Young DF, Tsai FY (1973) Flow characteristics in models of arterial stenosis: 1. Unsteady flow. J Biomech 6:547–559PubMedCrossRefGoogle Scholar
  4. 4.
    Buckberg GD, Fixier DE, Archie JP, Hoffman JIE (1972) Experimental subendocardial ischemia in dogs with normal coronary arteries. Circ Res 30:67–81PubMedGoogle Scholar
  5. 5.
    Furuse A, Klopp EH, Brawley RK, Gott VL (1975) Hemodynamic determinations in the assessment of distal coronary artery disease. J Surg Res 19:25–33PubMedCrossRefGoogle Scholar
  6. 6.
    Gould KL (1978) Pressure-flow characteristics of coronary stenosis in unsedated dogs at rest and during coronary vasodilation. Circ Res 43:242–253PubMedGoogle Scholar
  7. 7.
    Kajiya F, Tsujioka K, Ogasawara Y, Hiramatsu O, Wada Y, Goto M, Yanaka M (1989) Analysis of the characteristics of the flow velocity waveforms in left atrial small arteries and veins in the dog. Circ Res 65:1172–1181PubMedGoogle Scholar
  8. 8.
    Douglas JE, Greenfield JC, Jr (1970) Epicardial coronary artery compliance in the dog. Circ Res 27:921–929PubMedGoogle Scholar
  9. 9.
    Chilian WM, Marcus ML (1982) Phasic coronary blood flow velocity in intramural and epicardial coronary arteries. Circ Res 50:775–781PubMedGoogle Scholar
  10. 10.
    Chilian WM, Marcus ML (1985) Effects of coronary and extravascular pressure on intramyocardial and epicardial blood velocity. Am J Physiol 248 (Heart Circ Physiol 17):H170-H178PubMedGoogle Scholar
  11. 11.
    Carew TE, Covell JW (1976) Effect of intramyocardial pressure on the phasic flow in the intraventricular septal artery. Cardiovasc Res 10:56–64PubMedCrossRefGoogle Scholar
  12. 12.
    Eckstein RW, Moir TW, Driscol TE (1963) Phasic and mean blood flow in the canine septal artery and an estimate of systolic resistance in deep myocardial vessels. Circ Res 12:203–211Google Scholar
  13. 13.
    Kajiya F, Tomonaga G, Tsujioka K, Ogasawara Y, Nishihara H (1985) Evaluation of local blood flow velocity in proximal and distal coronary arteries by laser Doppler method. J Biomech Eng 107:10–15PubMedCrossRefGoogle Scholar
  14. 14.
    Ogasawara Y, Hiramatsu O, Kagiyama M, Tsujioka K, Tomonaga G, Kajiya F, Yanashima T, Kimura Y (1984) Evaluation of blood velocity profile by high frequency ultrasound pulsed Doppler velocimeter by a multigated zerocross method together with a Fourier transform method. IEEE Comput Cardiol 447–450Google Scholar
  15. 15.
    Kajiya F, Ogasawara Y, Tsujioka K, Nakai M, Goto M, Wada Y, Tadaoka S, Matsuoka S, Mito K, Fujiwara T (1986) Evaluation of human coronary blood flow with an 80-channel pulsed Doppler velocimeter and zero-cross and Fourier transform methods during cardiac surgery. Circulation 75 [Suppl III]:III53-III60Google Scholar
  16. 16.
    Kajiya F, Hiramatsu O, Kimura A, Yamamoto T, Yada T, Ogasawara Y, Tsujioka K (1992) Blood velocity patterns in poststenotic regions and velocity waveforms for myocardial inflow associated with coronary artery stenosis in dogs. J Biomech Eng 114:385–390PubMedCrossRefGoogle Scholar
  17. 17.
    Kimura A, Hiramatsu O, Yamamoto T, Ogasawara Y, Yada T, Goto M, Tsujioka K, Kajiya F (1992) Effect of coronary stenosis on phasic pattern of septal artery in dogs. Am J Physiol 262:H1690-H1698PubMedGoogle Scholar
  18. 18.
    Goto M, Flynn AE, Doucette JW, Kimura A, Hiramatsu O, Yamamoto T, Ogasawara Y, Tsujioka K, Hoffman JIE, Kajiya F (1992) Effect of intracoronary nitroglycerin administration on phasic pattern and transmural distribution of flow during coronary artery stenosis. Circulation 85:2296–2304PubMedGoogle Scholar
  19. 19.
    Feigl EO, Buffington CW, Nathan HJ (1987) Adrenergic coronary vasoconstriction during myocardial underperfusion. Circulation 75 [Suppl I]:I1-I5PubMedGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1993

Authors and Affiliations

  • Fumihiko Kajiya
  • Osamu Hiramatsu
  • Akihiro Kimura
  • Masami Goto
  • Yasuo Ogasawara
  • Katsuhiko Tsujioka
    • 1
  1. 1.Department of Medical Engineering and Systems CardiologyKawasaki Medical SchoolKurashiki-shi, OkayamaJapan

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