Natural History of Esophageal Squamous Cell Carcinoma, with Special Reference to Evaluation of Clinical Growth Rate by Tumor Volume Doubling Time

  • Ken Haruma
  • Tadashi Tokutomi
  • Takehiro Shimamoto
  • Shinji Tanaka
  • Masaharu Yoshihara
  • Shinya Kishimoto
  • Koji Sumii
  • Goro Kajiyama
Conference paper


Esophageal carcinoma is a common malignancy with a poor prognosis, despite recent advances in treatment. We previously reported ten patients with rapidly growing squamous cell carcinomas of the esophagus, and showed that the rapid growth of this tumor explains both why it is seldom detected at an early stage and why prognosis is poor [1]. However, reports at variance with our findings have been published [2–4]. In particular, the selection of patients in our previous study may have presented a problem, particularly since the number was small. Moreover, to determine if tumor growth is actually rapid, it is necessary to evaluate tumor growth objectively by comparison with malignancies of other organs.


Squamous Cell Carcinoma Esophageal Squamous Cell Carcinoma Gastric Carcinoma Doubling Time Esophageal Carcinoma 
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Copyright information

© Springer-Verlag Tokyo 1993

Authors and Affiliations

  • Ken Haruma
  • Tadashi Tokutomi
  • Takehiro Shimamoto
  • Shinji Tanaka
  • Masaharu Yoshihara
  • Shinya Kishimoto
  • Koji Sumii
  • Goro Kajiyama
    • 1
  1. 1.First Department of Internal MedicineHiroshima University School of MedicineMinami-ku, Hiroshima, 734Japan

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