Abstract
Desmosomes are intercellular junctions, particularly characteristic of epithelial cells, and they are major contributors to cell-cell adhesion in many epithelial cells. Decreased intercellular adhesion has been reported for many carcinomas, and it has been suggested that in part, such alterations in adhesion may be due to changes in adhering junctions, such as the desmosome [1]. In the human urinary bladder, a correlation between decreased numbers of desmosomes and aggressiveness of transitional cell carcinomas has been reported [2]. To define highly malignant esophageal squamous cell carcinoma (SCC) we have investigated the relationship of desmosome numbers to tumor invasiveness and metastasis in esophageal SCCs in a quantitative electron microscopic study [3]. We have also studied this structure with reference to outcome, because all cases studied had been followed for at least 5 years.
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© 1993 Springer-Verlag Tokyo
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Koyama, T. et al. (1993). Studies on the Relationship Between Desmosomes and Metastasis and Prognosis of Esophageal Cancer. In: Nabeya, Ki., Hanaoka, T., Nogami, H. (eds) Recent Advances in Diseases of the Esophagus. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68246-2_82
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DOI: https://doi.org/10.1007/978-4-431-68246-2_82
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68248-6
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