Studies on the Relationship Between Desmosomes and Metastasis and Prognosis of Esophageal Cancer
Desmosomes are intercellular junctions, particularly characteristic of epithelial cells, and they are major contributors to cell-cell adhesion in many epithelial cells. Decreased intercellular adhesion has been reported for many carcinomas, and it has been suggested that in part, such alterations in adhesion may be due to changes in adhering junctions, such as the desmosome . In the human urinary bladder, a correlation between decreased numbers of desmosomes and aggressiveness of transitional cell carcinomas has been reported . To define highly malignant esophageal squamous cell carcinoma (SCC) we have investigated the relationship of desmosome numbers to tumor invasiveness and metastasis in esophageal SCCs in a quantitative electron microscopic study . We have also studied this structure with reference to outcome, because all cases studied had been followed for at least 5 years.
KeywordsEsophageal Cancer Esophageal Squamous Cell Carcinoma Transitional Cell Carcinoma Intercellular Junction Tumor Cell Surface
Unable to display preview. Download preview PDF.
- 1.Pauli BU, Alroy J, Weinstein RS (1983) In: Bryan GT, Cohen SM (eds) The pathology of bladder cancer, vol 2. CRC, Boca Raton, pp 41–140Google Scholar
- 3.Koyama T (1989) Studies on the relationship between desmosomes and the mode of infiltration and metastasis of esophageal cancer (in Japanese with English abstract). Nippon Geka Gakkai Zasshi (J Jpn Surg Soc) 90: 1–10Google Scholar
- 6.Hasegawa M (1990) Cytodynamic evaluation on the relationship between the mode of intracellular DNA content and the prognosis of esophageal cancer patients (in Japanese with English abstract). Nippon Geka Gakkai Zasshi (J Jpn Surg Soc) 91: 191–199Google Scholar
- 7.Rikitake H (1990) Studies on DNA content in ploidy patterns of esophageal cancer (in Japanese with English abstract). Nippon Geka Gakkai Zasshi (J Jpn Surg Soc) 91: 564–574Google Scholar
- 9.Coman DR (1944) Decreased mutual adhesiveness, a property of cells from squamous cell carcinoma. Cancer Res 4: 625–629Google Scholar