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Studies on the Relationship Between Desmosomes and Metastasis and Prognosis of Esophageal Cancer

  • Takashi Koyama
  • Masayuki Matsumori
  • Toshihiro Omori
  • Satoru Hayashi
  • Tetsuya Hattori
  • Nobuhisa Watanabe
  • Masayoshi Okada
  • Sakan Maeda
Conference paper

Abstract

Desmosomes are intercellular junctions, particularly characteristic of epithelial cells, and they are major contributors to cell-cell adhesion in many epithelial cells. Decreased intercellular adhesion has been reported for many carcinomas, and it has been suggested that in part, such alterations in adhesion may be due to changes in adhering junctions, such as the desmosome [1]. In the human urinary bladder, a correlation between decreased numbers of desmosomes and aggressiveness of transitional cell carcinomas has been reported [2]. To define highly malignant esophageal squamous cell carcinoma (SCC) we have investigated the relationship of desmosome numbers to tumor invasiveness and metastasis in esophageal SCCs in a quantitative electron microscopic study [3]. We have also studied this structure with reference to outcome, because all cases studied had been followed for at least 5 years.

Keywords

Esophageal Cancer Esophageal Squamous Cell Carcinoma Transitional Cell Carcinoma Intercellular Junction Tumor Cell Surface 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1993

Authors and Affiliations

  • Takashi Koyama
  • Masayuki Matsumori
  • Toshihiro Omori
  • Satoru Hayashi
  • Tetsuya Hattori
  • Nobuhisa Watanabe
  • Masayoshi Okada
    • 1
  • Sakan Maeda
    • 2
  1. 1.Department of Surgery, Division IIKobe University School of MedicineChuo-ku, Kobe, 650Japan
  2. 2.Department of Pathology, Division IIKobe University School of MedicineChuo-ku, Kobe, 650Japan

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