Amplification of hst-1 and int-2 Genes as a Biological Marker of High Malignancy for Human Esophageal Carcinomas
We have previously demonstrated that esophageal carcinomas have some genetic abnormalities and abnormal expression of growth factor-receptor systems. That is, expression of epidermal growth factor (EGF) and EGF receptor (EGFR) genes are expressed in about 40% of esophageal carcinomas and also EGF and transforming growth factor (TGF)-alpha, the ligands of hyperproduced EGFR in human esophageal carcinoma cells act as autocrine growth factors [1, 2]. Moreover, the prognosis of patients with positive expression is poorer than those without expression . We have also reported that coamplification of hst-1 and int-2 genes occurs in human esophageal carcinomas . In the present study, we examined whether the amplification of these gene might be a good prognostic marker of high malignancy for human esophageal carcinomas.
KeywordsEpidermal Growth Factor Receptor Esophageal Squamous Cell Carcinoma Esophageal Carcinoma Dysplastic Lesion Autocrine Growth Factor
Unable to display preview. Download preview PDF.
- 1.Yoshida K, Yasui W, Ito H, Tahara E (1991) Growth factors in progression of human esophageal and gastric carcinomas. Exp Pathol 40: 291–300Google Scholar