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Amplification of hst-1 and int-2 Genes as a Biological Marker of High Malignancy for Human Esophageal Carcinomas

  • Kazuhiro Yoshida
  • Hiroki Kuniyasu
  • Toshihiro Hirai
  • Tetsuya Toge
  • Eiichi Tahara
Conference paper

Abstract

We have previously demonstrated that esophageal carcinomas have some genetic abnormalities and abnormal expression of growth factor-receptor systems. That is, expression of epidermal growth factor (EGF) and EGF receptor (EGFR) genes are expressed in about 40% of esophageal carcinomas and also EGF and transforming growth factor (TGF)-alpha, the ligands of hyperproduced EGFR in human esophageal carcinoma cells act as autocrine growth factors [1, 2]. Moreover, the prognosis of patients with positive expression is poorer than those without expression [3]. We have also reported that coamplification of hst-1 and int-2 genes occurs in human esophageal carcinomas [4]. In the present study, we examined whether the amplification of these gene might be a good prognostic marker of high malignancy for human esophageal carcinomas.

Keywords

Epidermal Growth Factor Receptor Esophageal Squamous Cell Carcinoma Esophageal Carcinoma Dysplastic Lesion Autocrine Growth Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag Tokyo 1993

Authors and Affiliations

  • Kazuhiro Yoshida
    • 1
  • Hiroki Kuniyasu
    • 2
  • Toshihiro Hirai
    • 1
  • Tetsuya Toge
    • 1
  • Eiichi Tahara
    • 2
  1. 1.Department of Surgery, Research Institute for Nuclear Medicine and BiologyHiroshima UniversityMinami-ku, Hiroshima, 734Japan
  2. 2.First Department of Pathology, School of MedicineHiroshima UniversityMinami-ku, Hiroshima, 734Japan

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