Abstract
We have previously demonstrated that esophageal carcinomas have some genetic abnormalities and abnormal expression of growth factor-receptor systems. That is, expression of epidermal growth factor (EGF) and EGF receptor (EGFR) genes are expressed in about 40% of esophageal carcinomas and also EGF and transforming growth factor (TGF)-alpha, the ligands of hyperproduced EGFR in human esophageal carcinoma cells act as autocrine growth factors [1, 2]. Moreover, the prognosis of patients with positive expression is poorer than those without expression [3]. We have also reported that coamplification of hst-1 and int-2 genes occurs in human esophageal carcinomas [4]. In the present study, we examined whether the amplification of these gene might be a good prognostic marker of high malignancy for human esophageal carcinomas.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Yoshida K, Yasui W, Ito H, Tahara E (1991) Growth factors in progression of human esophageal and gastric carcinomas. Exp Pathol 40: 291–300
Yoshida K, Kyo E, Tsuda T, Tsujino T, Ito M, Niimoto M, Tahara E (1990) EGF and TGF-alpha, the ligands of hyperproduced EGFR in human esophageal carcinoma cells, act as autocrine growth factors. Int J Cancer 45: 131–135
Mukaida H, Toi M, Hirai T, Ysmashita Y, Toge T (1991) Clinical significance of the expression of epidermal growth factor and its receptor in esophageal cancer. Cancer 68: 142–148
Tsuda T, Tahara E, Kajiyama G, Sakamoto H, Terada M, Sugimura T (1989) High incidence of coamplification of hst-1 and int-2 genes in human esophageal carcinomas. Cancer Res 49: 5505–5508
Tsujino T, Yoshida K, Nakayama H, Ito H, Shimosato T, Tahata E (1990) Alterations of oncogenes in metastatic tumors of human gastric carcinomas. Br J Cancer 62: 226–230
Kiyokawa H, Busquets X, Powell CT, Ngo L, Rifkind RA, Marks PA (1992) Cloning of a D-type cyclin from murine erythro-leukemia cells. Proc Natl Acad Sci USA 89: 2444–2447
Jiang W, Kahn SM, Tomita N, Zhang Y-J, Lu S-H, Weinstein B (1992) Amplification and expression of human cyclin D gene in esophageal cancer. Cancer Res 52: 2980–2983
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer-Verlag Tokyo
About this paper
Cite this paper
Yoshida, K., Kuniyasu, H., Hirai, T., Toge, T., Tahara, E. (1993). Amplification of hst-1 and int-2 Genes as a Biological Marker of High Malignancy for Human Esophageal Carcinomas. In: Nabeya, Ki., Hanaoka, T., Nogami, H. (eds) Recent Advances in Diseases of the Esophagus. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68246-2_72
Download citation
DOI: https://doi.org/10.1007/978-4-431-68246-2_72
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68248-6
Online ISBN: 978-4-431-68246-2
eBook Packages: Springer Book Archive