Association of hst-1 Gene Amplification with Poor Postoperative Prognosis of Esophageal Carcinoma

Conference paper


In esophageal carcinoma, amplification of epidermal growth factor receptor and c-myc gene [1], and coamplification of hst-1 and int-2 genes [2, 3] have been reported. The incidence of coamplification of the hst-1 and int-2 genes was reported at 30%–50% and was correlated with poor prognosis and high incidence of postoperative recurrence in distal organs of esophageal carcinoma [4]. In this study, we examined whether or not the intensity of hst-1 amplification is associated with the grade of malignant potential, especially organ metastasis, of esophageal carcinoma.


Epidermal Growth Factor Receptor Esophageal Carcinoma Esophageal Disease Human Esophageal Cancer Esophageal Squamous Carcinoma 
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Copyright information

© Springer-Verlag Tokyo 1993

Authors and Affiliations

  1. 1.First Department of SurgeryOita Medical UniversityHasama-machi, OitaJapan

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