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Association of hst-1 Gene Amplification with Poor Postoperative Prognosis of Esophageal Carcinoma

  • Kiyone Chikuba
  • Takao Saito
  • Shinya Uchino
  • Kouich Sato
  • Katsuhiro Shimoda
  • Masaki Miyahara
  • Michio Kobayashi
Conference paper

Abstract

In esophageal carcinoma, amplification of epidermal growth factor receptor and c-myc gene [1], and coamplification of hst-1 and int-2 genes [2, 3] have been reported. The incidence of coamplification of the hst-1 and int-2 genes was reported at 30%–50% and was correlated with poor prognosis and high incidence of postoperative recurrence in distal organs of esophageal carcinoma [4]. In this study, we examined whether or not the intensity of hst-1 amplification is associated with the grade of malignant potential, especially organ metastasis, of esophageal carcinoma.

Keywords

Epidermal Growth Factor Receptor Esophageal Carcinoma Esophageal Disease Human Esophageal Cancer Esophageal Squamous Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Lu SH, Hsieh LL, Luo FC, Weinstein IB (1988) Amplification of the EGF receptor and c-myc genes in human esophageal cancers. Int J Cancer 42: 502–505PubMedCrossRefGoogle Scholar
  2. 2.
    Tsutsumi M, Sakamoto H, Yoshida T, Kakizoe T, Koiso K, Sugimura T, Terada M (1988) Coamplification of the hst-1 and int-2 genes in human cancers. Jpn J Cancer Res (Gann) 79: 428–432CrossRefGoogle Scholar
  3. 3.
    Tsuda T, Tahara E, Kajiyama G, Sakamoto H, Terada M, Sugimura T (1989) High incidence of coamplification of hst-1 and int-2 genes in human esophageal carcinoma. Cancer Res 49: 5505–5508PubMedGoogle Scholar
  4. 4.
    Kitagawa Y, Ueda M, Ando N, Shinozawa Y, Shimizu N, Abe O (1991) Significance of int-2/hst-1 coamplification as a prognostic factor in patients with esophageal squamous carcinoma. Cancer Res 51: 1504–1508PubMedGoogle Scholar
  5. 5.
    Japanese Society for Esophageal Disease (1992) Guidelines for the Clinical and Pathologic Studies on Carcinoma of the Esophagus, 8th ed. Kanehara, TokyoGoogle Scholar
  6. 6.
    Goelz SE, Hamilton SR, Vogelstein B (1985) Purification of DNA formaldehyde-fixed and paraffin-embedded human tissue. Biochem Biophys Res Commun 130: 118–126PubMedCrossRefGoogle Scholar
  7. 7.
    Feinberg AP, Vogelstein B (1983) A technique for radiolabeling DNA restriction endo-nuclease fragments to high specific activity. Anal Biochem 132: 6–13PubMedCrossRefGoogle Scholar
  8. 8.
    Sakamoto H, Mori M, Taira M, Yoshida T, Matsukawa S, Shimizu K, Sekiguchi M, Terada M, Sugimura T (1986) Transforming gene from human stomach cancers and a noncancerous portion of stomach mucosa. Proc Natl Acad Sci USA 83: 3997–4001PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1993

Authors and Affiliations

  • Kiyone Chikuba
  • Takao Saito
  • Shinya Uchino
  • Kouich Sato
  • Katsuhiro Shimoda
  • Masaki Miyahara
  • Michio Kobayashi
    • 1
  1. 1.First Department of SurgeryOita Medical UniversityHasama-machi, OitaJapan

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