Interaction Between Epidermal Growth Factor and Its Receptor in the Progression of Human Esophageal Carcinoma

  • Akira Kawaguchi
  • Jyunsuke Shibata
  • Hiroyuki Naito
  • Masashi Kodama
Conference paper


Epidermal growth factor (EGF) is known to stimulate the growth and proliferation of various cells through interaction with its receptors (EGFR) [1–3]. In esophageal carcinoma, it has been reported that many squamous cell carcinomas express a large number of EGF receptors [4–7]. Furthermore, it has been suggested that the patients with EGF receptor-positive tumor has a worse prognosis than those with EGF receptor-negative tumors [6–7]. Thus, the expression of EGF receptors have been a focus of attention to be a significant prognostic indicator for esophageal carcinoma. However, as for the EGF, there had been no agreement regarding the effect of EGF on the progression of esophageal carcinoma in vivo and in vitro [3–9].


Epidermal Growth Factor Receptor Proliferative Cell Nuclear Antigen Labelling Index Esophageal Carcinoma Epidermal Growth Factor Receptor Expression 
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Copyright information

© Springer-Verlag Tokyo 1993

Authors and Affiliations

  • Akira Kawaguchi
  • Jyunsuke Shibata
  • Hiroyuki Naito
  • Masashi Kodama
    • 1
  1. 1.First Department of SurgeryShiga University of Medical ScienceTsukinowa-cho, Seta, Otsu, ShigaJapan

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