Patterns of Presentation of Carcinoma of the Esophagus and Cardia in Patients Less Than 50 Years Old
Squamous cell carcinomas of the esophagus in the Western hemisphere are epidemiologically related to tobacco use and alcohol consumption. In the past 10 years, there has been a striking increase in the incidence of adenocarcinomas of the distal esophagus and cardia, many of which do not arise from Barrett’s mucosa. Coincident with this rise in the incidence of adenocarcinomas has been an apparent shift to involvement in younger patients, most of whom do not share the risk factors associated with squamous cell cancers. We reviewed our recent experience with carcinoma of the esophagus and cardia to address several questions. Is the prevalence of cancer among young people increasing? Do young people develop a different type of cancer than that seen in older individuals, and, if so, do their prognoses differ? Can risk factors be identified that facilitate earlier diagnosis in young people?
KeywordsAlcohol Consumption Distal Esophagus Reflux Symptom Squamous Cell Cancer Gastric Cardia
Unable to display preview. Download preview PDF.
- 9.Mathisen DJ, Wilkins EW, Grillo HC, Moncure AC (1988) Adenocarcinoma in columnar lined esophagus (Barrett’s esophagus). In: Siewert JR, Holscher AH (eds) Diseases of the esophagus. Springer, Berlin Heidelberg New York, pp 559–561Google Scholar
- 10.Nogami H, Stephens JK, Ferguson MK, Nabeya K-I (1990) Glycoprotein alterations in Barrett’s esophagus, adenocarcinoma arising in Barrett’s epithelium and adenocarcinoma of the gastroesophageal junction. In: Ferguson MK, Little AG, Skinner DB (eds) Diseases of the esophagus, vol I: Malignant diseases. Mount Kisco, New York, pp 17–23Google Scholar