A Histopathological Study of Barrett’s Esophagus with Special Reference to the Specialized Columnar Epithelium

  • Shin-ichi Nakamura
  • Isamu Kino
  • Tomio Arai
  • Katunori Aoki
Conference paper


Barrett’s esophagus is defined as a lesion in which the squamous epithelium of the lower esophagus is replaced extensively by columnar epithelium [1–3]. Three different kinds of columnar mucosa are observed in Barrett’s esophagus: Atrophic gastric fundic mucosa, junctional mucosa similar to the gastric cardia, and an intestinal type bearing “specialized columnar epithelium” (SCE) [4, 5].


Intestinal Metaplasia Columnar Epithelium Lower Esophagus Absorptive Cell Gastric Intestinal Metaplasia 


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  1. 1.
    Barrett NR (1950) Chronic peptic ulcer of the oesophagus and “oesophagitis’. Br J Surg 38: 175–182PubMedCrossRefGoogle Scholar
  2. 2.
    Barrett NR (1957) The lower esophagus lined by columnar epithelium. Surgery 41: 881–894PubMedGoogle Scholar
  3. 3.
    Burgess JN, Payne WS, Andersen HA, Weiland LH, Carlson HC (1971) Barrett’s esophagus. The columnar-epithelial-lined lower esophagus. Mayo Clin Proc 46: 728–734Google Scholar
  4. 4.
    Trier JS (1970) Morphology of the epithelium of the distal esophagus in patients with midesophageal peptic strictures. Gastroenterology 58: 444–461PubMedGoogle Scholar
  5. 5.
    Paull A, Trier JS, Dalton D, Camp RC, Loeb P, Goyal RK (1976) The histologic spectrum of Barrett’s esophagus. N Engl J Med 295: 476–480PubMedCrossRefGoogle Scholar
  6. 6.
    Mangla JC (1981) Barrett’s esophagus: An old entity rediscovered. J Clin Gastroenterol 3: 347–356PubMedCrossRefGoogle Scholar
  7. 7.
    Filipe MI, Bogomoletz W, Dawson P, Fabiani B, Potet F (1983) Intestinal metaplasia subtypes in the assessment of gastric cancer risk. A multicentric prospective study. Gut 24: A974–A975Google Scholar
  8. 8.
    Katsuyama T, Spicer SS (1978) Histochemical differentiation of complex carbohydrates with variants of the concanavalin A-horse radish peroxidase method. J Histochem Cytochem 26: 233–250PubMedCrossRefGoogle Scholar
  9. 9.
    Berenson MM, Herbst JJ, Freston JW (1974) Enzyme and ultrastructural characteristics of esophageal columnar epithelium. Dig Dis Sci 19: 895–907CrossRefGoogle Scholar
  10. 10.
    Levine DS, Rubin CE, Reid BJ, Haggitt RC (1989) Specialized metaplastic columnar epithelium in Barrett’s esophagus. A comparative transmission electron microscopic study. Lab Invest 60: 418–432Google Scholar
  11. 11.
    Ming SC, Goldman H, Freiman DG (1967) Intestinal metaplasia and histogenesis of carcinoma in human stomach. Light and electron microscopic study. Cancer 20: 1418–1429Google Scholar
  12. 12.
    Iida F, Murata F, Nagata T (1978) Histochemical studies of mucosubstances in metaplastic epithelium of the stomach, with special reference to the development of intestinal metaplasia. Histochemistry 56: 229–237PubMedCrossRefGoogle Scholar
  13. 13.
    Matsukura N, Suzuki K, Kawachi T, Aoyagi M, Sugimura T, Kitaoka H, Numajiri H, Shirota A, Itabashi M, Hirota T (1980) Distribution of marker enzymes and mucin in intestinal metaplasia in human stomach and relation of complete and incomplete types of intestinal metaplasia to minute gastric carcinomas. JNCI 65: 231–240PubMedGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1993

Authors and Affiliations

  • Shin-ichi Nakamura
    • 1
  • Isamu Kino
    • 2
  • Tomio Arai
    • 2
  • Katunori Aoki
    • 3
  1. 1.Department of PathologyHamamatsu University HospitalHamamatsuJapan
  2. 2.First Department of PathologyHamamatsu University School of MedicineHamamatsuJapan
  3. 3.Emergency DepartmentHamamatsu University HospitalHamamatsuJapan

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