Advertisement

An Alkaline Stomach Is Common to Barrett’s Esophagus and Gastric Carcinoma

  • Akihiro Yasui
  • Sebastian F. Hoeft
  • Hubert J. Stein
  • Tom R. DeMeester
  • Ross M. Bremner
  • Yuji Nimura

Abstract

The interdigestive pH environment of the stomach fluctuates from 1 to 2. A rise in pH to above 3 occurs either from decreased acid secretion, as in achlorhydria, or iatrogenic acid reduction (anti-secretory drugs: H2-blockers, proton pump inhibitors), neutralization of acid from swallowed food, or reflux of alkaline pancreatic and biliary secretions from the duodenum.

Keywords

Gastric Cancer Lower Esophageal Sphincter Duodenal Juice Early Gastric Carcinoma Duodenogastric Reflux 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Fuchs KH, DeMeester TR, Hinder RA, Stein HJ, Barlow AP, Gupta N (1991) Computerized identification of pathologic reflux using 24-h gastric pH monitoring. Ann Surg 213: 13–20PubMedCrossRefGoogle Scholar
  2. 2.
    Attwood SEA, DeMeester TR, Bremner CG, Barlow AP, Hinder RA (1991) Alkaline gastroesophageal reflux: Implications in the development of complications in Barrett’s esophagus. Surgery 106: 563–566Google Scholar
  3. 3.
    Williamson RCN, Bauer FLR, Ross JS, et al (1978) Contributions of bile and pancreatic juice to cell proliferation in ileal mucosa. Surgery 83: 570–576PubMedGoogle Scholar
  4. 4.
    Deschner EE (1988) Cell proliferation and colonic neoplasia. Scand J Gastroenterol 23 [Suppl 151]: 94–97CrossRefGoogle Scholar
  5. 5.
    Williamson RCN, Rainey JB (1984) The relationship between intestinal hyperplasia and carcinogenesis. Scand J Gastroenterol 19 [Suppl 104]: 57–76Google Scholar
  6. 6.
    Bechi P, Balzi M, Becciolini A, Amorosi A, Scubla E, et al (1991) Gastric cell proliferation and bile reflux after partial gastrectomy. Am J Gastroent 86 (10): 1424–1432PubMedGoogle Scholar
  7. 7.
    Pellegrini CA, DeMeester TR, Wernly JA, Johnson LF, Skinner DB (1978) Alkaline gastroesophageal reflux. Am J Surg 135: 177–184PubMedCrossRefGoogle Scholar
  8. 8.
    Stein HJ, Hinder RA, DeMeester TR, Lloyd BA, Fuchs KH, Attwood SEA, Gupta NC (1990) Clinical use of 24-h gastric pH monitoring vs o-diisopropyl iminodiacetic acid ( DISIDA) scanning in the diagnosis of pathologic duodenogastric reflux. Arch Surg 125: 966–971PubMedCrossRefGoogle Scholar
  9. 9.
    Domellof L, Janunger KG (1977) The risk for gastric carcinoma after partial gastrectomy. Am J Surg 134: 581–584PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1993

Authors and Affiliations

  • Akihiro Yasui
    • 1
  • Sebastian F. Hoeft
    • 2
  • Hubert J. Stein
    • 2
  • Tom R. DeMeester
    • 2
  • Ross M. Bremner
    • 2
  • Yuji Nimura
    • 1
  1. 1.First Department of SurgeryNagoya University School of MedicineShowa-ku, Nagoya, Aichi, 466Japan
  2. 2.School of Medicine, Department of SurgeryUniversity of Southern CaliforniaLos AngelesUSA

Personalised recommendations