Surgical Treatment of Barrett’s Carcinoma: Correlation Between Morphologic Findings and Prognosis
Barrett’s esophagus or columnar epithelium-lined lower esophagus is a disorder in which the normal squamous cell epithelium is replaced by a metaplastic columnar mucosa. It is estimated that it occurs in about 10% of the patients suffering from gastroesophageal reflux. The importance of Barrett’s esophagus is related to the high frequency of its association with degeneration into adenocarcinoma with a prevalence varying from 10% to 45% [1, 2]. The true risk is estimated at 30–40 times higher than within the general population . As the diagnosis is frequently made in an advanced stage, the prognosis of a Barrett adenocarcinoma is reported to be poor . Early diagnosis of such adenocarcinomas certainly could improve significantly the prognosis, and this opens the debate concerning surveillance programs in patients with Barrett’s metaplasia. We have been analyzing our experience with Barrett’s adenocarcinomas focusing on the results of surgical treatment and trying to establish a correlation between histomorophological findings of Barrett’s metaplasia and risk of degeneration.
KeywordsEsophageal Carcinoma Intestinal Metaplasia High Grade Dysplasia Morphologic Finding Mosaic Pattern
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- 1.Hameeteman W, Tytgat GNJ, Houthoff HJ, van den Tweel JG (1988) Barrett’s esophagus: Development of dysplasia and adenocarcinoma. Gastroenterology 96: 1249–1256Google Scholar