Advertisement

Regression of Columnar Metaplasia of the Lower Esophagus in a Canine Model

  • H. Li
  • T. N. Walsh
  • G. O’Dowd
  • P. G. Gillen
  • P. J. Byrne
  • T. P. J. Hennessy
Conference paper

Abstract

It is generally accepted that Barrett’s esophagus is acquired due to longstanding gastroesophageal reflux which destroys the squamous epithelium, replacing it with acid resistant gastric-type epithelium [1–3]. Regression of this epithelium should reduce the risk of cancer and other complications. The evidence that regression can occur is conflicting and no large series has demonstrated it convincingly. This study compared regeneration in the presence of stimulated acid reflux with healing in the presence of acid control.

Keywords

Hiatus Hernia Squamous Epithelium Columnar Epithelium Esophageal Mucosa Lower Esophagus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Borrie J, Goldwater L (1976) Columnar cell-lined esophagus: Assessment of etiology and treatment. A 22-year experience. J Thorac Cardiovasc Surg 71: 825–834PubMedGoogle Scholar
  2. 2.
    Iascone C, DeMeester TR, Little AG, Skinner DB (1983) Barrett’s esophagus: functional assessment, proposed pathogenesis, and surgical therapy. Arch Surg 118: 543–549PubMedCrossRefGoogle Scholar
  3. 3.
    Bremner CG (1989) Barrett’s esophagus. Br J Surg 76: 995–996PubMedCrossRefGoogle Scholar
  4. 4.
    Savary M, Miller G (1978) The esophagus. Handbook and atlas of endoscopy. Gassman, Saluthurn, pp 119–205Google Scholar
  5. 5.
    Hennessy TPJ, Edlich RF, Buchin RJ, Tsung MS, Prevost M, Wangensteen OH (1968) Influence of gastroesophageal incompetence on regeneration of esophageal mucosa. Arch Surg 97: 105–107PubMedCrossRefGoogle Scholar
  6. 6.
    Bremner CG, Lynch VP, Ellis FH Jr (1970) Barrett’s esophagus: Congenital or acquired? An experimental study of esophageal mucosal regeneration in the dog. Surgery 68: 209–216PubMedGoogle Scholar
  7. 7.
    Gillen P, Keeling P, Byrne PJ, West AB, Hennessy TPJ (1988) Experimental columnar metaplasia in the canine esophagus. Br J Surg 75: 113–115PubMedCrossRefGoogle Scholar
  8. 8.
    Creamer B, Shorter RG, Bamforth J (1961) The turnover and shedding of epithelial cells. Part I. The turnover in the gastrointestinal tract. Gut 2: 110–118PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1993

Authors and Affiliations

  • H. Li
  • T. N. Walsh
  • G. O’Dowd
  • P. G. Gillen
  • P. J. Byrne
  • T. P. J. Hennessy
    • 1
  1. 1.University Department of SurgerySt James’s HospitalDublin 8Ireland

Personalised recommendations