Abstract
Surgical treatment for esophageal cancer, which includes thoracotomy, laparotomy, and three-field lymph node dissection [1] followed by reconstruction, is one of the most severe operative procedures resulting in an increased protein catabolism with supressed immune function. Growth hormone has a strong anabolic effect and became applicable for clinical use owing to the availability of recombinant human growth hormone (rhGH) by the development of bioengineering techniques. The effects of rhGH in the stressed state were investigated experimentally and clinically.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Isono K, Sato H, Nakayama K (1991) Results of nationwide study on the three–field lymph node dissection of esophageal cancer. Oncology 48: 411–420
Tashiro T, Meng HC (1981) A technique for long-term parenteral nutrition in unrestrained weaning rats. Jpn J Ped Surg 17: 667–673
Stein TP, Leskiw JM, Buzby GP (1980) Measurement of protein synthsis rates with 15N- glycine. Am J Physiol 239: E294 - E300
Tashiro T, Yamamori H, Mashima Y (1984) The measurement of whole-body protein turnover in surgical patients recieving total parenteral nutrition ( TPN ). Jpn J Surg Metab Nutr 18: 403–409
Fujisaki Y, Tashiro T, Mashima Y, Yamamori H (1992) Adequate requirement of energy and protein in postoperative total parenteral nutrition. Jpn J Surg 93: 119–127
Ziegler TR, Young LS, Manson JM, Wilmore DW (1988) Metabolic effects of recombinant human growth hormone in patiens recieving parenteral nutrition. Ann Surg 208: 6–16
Ziegler TR, Young LS, Ferrari-Baliviera E, Demling RH, Wilmore DW (1990) Use of human growth hormone combined with nutritional support in a critical care unit. JPEN 14: 574–581
Douglas RG, Humberstone DA, Haystead A, Shaw JHF (1990) Metabolic effects of recombinant human growth hormone: isotopic studies in the postabsorptive state and during total parenteral nutrition. Br J Surg 7: 785–790
Ward HC, Hailiday D, Sim AJW (1987) Protein and energy metabolism with biosynthetic human growth hormone after gastrointestinal surgery. Ann Surg 206: 56–61
Jiang Z, He G, Wang X, Yang N, Zhu Y, Wilmore DW (1989) Low dose growth hormone and hypocaloric nutrition attenuate the proteincatabolic response after major operation. Ann Surg 210: 513–525
Belcher HJCR, Mercer D, Judkins KC, Shalaby S, Wise S, Marks V, Tanner NSB (1989) Biosynthetic human growth hormone in burned patients: A pilot study. Burns 15: 99–107
Gattardis M, Benzer A, Koller W, Luger TJ, Puhringer F, Hack IJ (1991) Improvement of septic syndrome after administration of recombinant growth hormone (rhGH). J Trauma 31: 81–86
Manson JM, Smith RJ, Wilmore DW (1988) Growth hormone stimulates protein synthsis during hypocaloric parenteral nutrition. Ann Surg 208: 136–142
Horber FF, Haymond MW (1990) Human growth hormone prevents the protein catabolic side effects of predonisone in humans. J Clin Invest 86: 265–272
Herndon DN, Barrow RE, Kunkel KR, Broemeling L, Rutan RL (1990) Effect of recombinant human growth hormone on donor-site healing in severely burned children. Ann Surg 212: 424–431
Crist DM, Kraner JC (1990) Supplemental growth hormone increases the tumor cytotoxic activity of natural killer cells in healthy adults with normal growth hormone secretion. Metabolism 39: 1320–1324
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer-Verlag Tokyo
About this paper
Cite this paper
Tashiro, T., Takagi, K., Mashima, Y., Yamamori, H., Nishizawa, M., Nakajima, N. (1993). Recombinant Human Growth Hormone Improves Postoperative Protein Retention of Patients Receiving Esophagectomy. In: Nabeya, Ki., Hanaoka, T., Nogami, H. (eds) Recent Advances in Diseases of the Esophagus. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68246-2_168
Download citation
DOI: https://doi.org/10.1007/978-4-431-68246-2_168
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68248-6
Online ISBN: 978-4-431-68246-2
eBook Packages: Springer Book Archive