Efficacy of Hyperthermia for Advanced Esophageal Carcinoma
The prognosis of patients with advanced cancer of the esophagus is very poor. To control advanced esophageal carcinoma nonoperatively, irradiation and chemotherapy have been applied. However, the clinical effectiveness of these treatments has not been satisfactory. Hyperthermia has recently received attention since neoplastic cells have been reported to have greater heat-sensitivity than normal cells, and because this method has been confirmed to enhance the anticancer effect of radiation and some anticancer drugs. We have employed multidisciplinary treatment consisting of radiotherapy, chemotherapy, and hyperthermia, since 1985 . This treatment protocol was derived from basic experiments using cultured cells of human cancer of the esophagus. This is a report of our study on the efficacy of hyperthermia in combined treatment.
KeywordsEsophageal Cancer Pulmonary Fibrosis Esophageal Carcinoma Small Cell Carcinoma Multidisciplinary Treatment
Unable to display preview. Download preview PDF.
- 1.Fujimaki M, Katoh H, Tazawa K, Yamashita I, Sakamoto T, Yamada A (1990) Adjuvant hyperthermia in nonresectable esophageal carcinoma. In: Ferguson MK, Little AG, Skinner DB (eds) Disease of the esophagus, vol. 1: Malignant diseases. Fut 317–322Google Scholar
- 2.Japanese Society for Esophageal Diseases (1992) Guidelines for the cli studies on carcinoma of the esophagus. Kanehara, Tokyo, pp 32–58Google Scholar
- 3.Shinbo T, Katoh H, Saitoh M, Saitoh T, Shimizu T, Otagiri H, (1989) Effect of thermotherapy on human esophageal carcinoma in cases. Gan to Kagaku Ryoho (Jpn J Cancer Chemother) 16 (4): 1899–1904Google Scholar
- 4.Sugimachi K, Inokuchi K, Kai H, Sogawa A, Kawai Y (1983) En application of hyperthermia to malignant lesions. Jpn J Cancer Res (Gann) 74: 622–624Google Scholar