Preoperative Concurrent Chemotherapy and Radiotherapy of Squamous Cell Carcinoma of the Thoracic Esophagus: A Pilot Study Report
In Poland, 1300 new cases of carcinoma of the esophagus are registered each year and it ranges from 1.1 in women to 4.8 in men per 100,000 population . Most of the esophageal cancer patients admitted to the hospitals are in an advanced stage of the disease, and this is mainly responsible for the low operability/resecability rates and therefore poor long-term results of treatment (5-year survival is around 4%, the lowest of all gastro-intestinal cancers). Since no significant progress in early diagnosis has been observed, the attempts to improve the results concentrate on combining other modes of treatment (e.g., radio- and/or chemotherapy) before surgery (Fig. 1). Currently, surgery, whenever possible, remains the treatment of choice for carcinoma of the esophagus aimed at palliation or cure, whether or not it is associated with radiotherapy pre- and/or postoperatively. The place and the role of chemotherapy (combined or monotherapy) in the treatment program for esophageal carcinoma is still unproven, and is under evaluation for its potential benefits by ongoing prospective clinical trials.
KeywordsSquamous Cell Carcinoma Clin Oncol Concurrent Chemotherapy Thoracic Esophagus Esophageal Cancer Patient
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