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Preoperative Concurrent Chemotherapy and Radiotherapy of Squamous Cell Carcinoma of the Thoracic Esophagus: A Pilot Study Report

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Recent Advances in Diseases of the Esophagus

Abstract

In Poland, 1300 new cases of carcinoma of the esophagus are registered each year and it ranges from 1.1 in women to 4.8 in men per 100,000 population [1]. Most of the esophageal cancer patients admitted to the hospitals are in an advanced stage of the disease, and this is mainly responsible for the low operability/resecability rates and therefore poor long-term results of treatment (5-year survival is around 4%, the lowest of all gastro-intestinal cancers). Since no significant progress in early diagnosis has been observed, the attempts to improve the results concentrate on combining other modes of treatment (e.g., radio- and/or chemotherapy) before surgery (Fig. 1). Currently, surgery, whenever possible, remains the treatment of choice for carcinoma of the esophagus aimed at palliation or cure, whether or not it is associated with radiotherapy pre- and/or postoperatively. The place and the role of chemotherapy (combined or monotherapy) in the treatment program for esophageal carcinoma is still unproven, and is under evaluation for its potential benefits by ongoing prospective clinical trials.

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References

  1. Zatonski W, Tarkowski W, Chmielarczyk W, Tyczynski J (1990) Cancer in Poland. National Cancer Registry, Warsaw, pp 29–56

    Google Scholar 

  2. Illustrated Guide to the TNM/pTNM classification of malignant tumors (1992). International Union Against Cancer ( 3rd edn. ). Springer, Berlin Heidelberg New York, pp 62–70

    Google Scholar 

  3. Forastiere AA, Orringer MB, Perez-Tamayo C, Urba SG, Husted S, Takasugi BJ, Zahurak M (1990) Concurrent chemotherapy and radiation therapy followed by transhiatal esophagectomy for local regional cancer of the esophagus. J Clin Oncol 8 (1): 119–127

    PubMed  CAS  Google Scholar 

  4. Lewis J (1946) The surgical treatment of carcinoma of the oesophagus with special reference to a new operation for growths of the middle third. Br J Surg 34: 18–27

    Article  PubMed  CAS  Google Scholar 

  5. Akiyama H, Miyazono H, Tsurumaru M, Hashimoto C, Kawamura T (1978) Use of the stomach as an esophageal substitute. Ann Surg 188 (5): 606–610

    Article  PubMed  CAS  Google Scholar 

  6. Forastiere AA, Belliveau JF, Goren MP, Vogel WC, Posner MR, O’Leary GP (1988) Pharmacokinetic and toxicity evaluation of 5-day continuous infusion versus intermittent bolus cis-Diamminedichloroplatinum ( II) in head and neck cancer patients. Cancer Res 48: 3869–3874

    PubMed  CAS  Google Scholar 

  7. Lokich JJ, Shea M, Chaffey J (1987) Sequential infusional 5-fluorouracil followed by concomitant radiation for tumors of the esophagus and gastrointestinal junction. Cancer 60: 275–279

    Article  PubMed  CAS  Google Scholar 

  8. Byfield JE, Barone R, Mendelsohn J, Frankel S, Quinol L, Sharp T, Seagren S (1980) Infusional 5-FU and x-ray therapy for non-resectable esophageal cancer. Cancer 45: 703–708

    Article  PubMed  CAS  Google Scholar 

  9. Rich TA, Lokich JJ, Chaffey JT (1985) A pilot study of protracted venous infusion of 5-fluorouracil and concomitant radiation therapy. J Clin Oncol 3: 402–406

    PubMed  CAS  Google Scholar 

  10. Dewit L (1987) Combined treatment of radiation and cis-diamminedichloroplatinum (II). A review of experimental and clinical data. Int J Oncol Biol Phys 13: 403–426

    Article  CAS  Google Scholar 

  11. Pinedo HM, Karim ABMF, van Vliet WH, Snow GB, Vermorken JB (1983) Daily cis-dichlorodiammineplatinum ( II) as a radio-enhancer: A preliminary toxicity report. J Cancer Res Clin Oncol 105: 79–82

    Article  PubMed  CAS  Google Scholar 

  12. Leichman L, Steiger Z, Seydel HG, Vaitkevicius VK (1984) Preoperative chemotherapy and radiation therapy for patients with cancer of the esophagus. A potentially curative approach. Semin Oncol 11: 178–185

    PubMed  CAS  Google Scholar 

  13. Poplin E, Fleming T, Leichman L (1987) Combined therapies for squamous cell carcinoma of the esophagus, a Southwest Oncology Group Study (SWOG 8037). J Clin Oncol 5: 622–628

    PubMed  CAS  Google Scholar 

  14. Seydel HG, Leichman L, Byhardt R, Cooper J, Herskovic A, Libnock J, Pazdur R, Speyer J, Tschan J and the Radiation Therapy Oncology Group (1988) Preoperative radiation and chemotherapy for localized squamous cell carcinoma of the esophagus: ARTOG study. Int J Radiat Oncol Biol Phys 14: 33–35

    Article  PubMed  CAS  Google Scholar 

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© 1993 Springer-Verlag Tokyo

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Szawlowski, A.W. et al. (1993). Preoperative Concurrent Chemotherapy and Radiotherapy of Squamous Cell Carcinoma of the Thoracic Esophagus: A Pilot Study Report. In: Nabeya, Ki., Hanaoka, T., Nogami, H. (eds) Recent Advances in Diseases of the Esophagus. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68246-2_154

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  • DOI: https://doi.org/10.1007/978-4-431-68246-2_154

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68248-6

  • Online ISBN: 978-4-431-68246-2

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