Advanced and Recurrent Esophageal Carcinoma: Combination Chemotherapy with Etoposide, Leucovorin, 5-Fluorouracil, and Cisplatin
Survival of patients with esophageal carcinoma treated with surgery and/or radiation has been very poor. The clinical development of cisplatin (CDDP) based chemotherapy has changed the outcome of patients with esophageal carcinoma. The combinations of 5-fluorouracil (5-FU) and CDDP, 5-FU and leucovorin, and CDDP and etoposide are synergistic in experimental and clinical models. We have used etoposide, leucovorin, 5-FU, and CDDP in advanced or recurrent esophageal squamous cell carcinoma since January, 1991, and we evaluate herein the tumor reduction and the postoperative morbidity and mortality.
KeywordsEsophageal Squamous Cell Carcinoma Esophageal Carcinoma Human Granulocyte Colony Stimulate Factor Distant Lymph Node Metastasis Esophageal Squamous Carcinoma
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