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Advanced and Recurrent Esophageal Carcinoma: Combination Chemotherapy with Etoposide, Leucovorin, 5-Fluorouracil, and Cisplatin

  • Susumu Ohwada
  • Yuichi Iino
  • Seiji Nakamura
  • Yoshihumi Tanahashi
  • Yoshiyuki Kawashima
  • Yukio Miyamoto
  • Yasuo Morishita
Conference paper

Abstract

Survival of patients with esophageal carcinoma treated with surgery and/or radiation has been very poor. The clinical development of cisplatin (CDDP) based chemotherapy has changed the outcome of patients with esophageal carcinoma. The combinations of 5-fluorouracil (5-FU) and CDDP, 5-FU and leucovorin, and CDDP and etoposide are synergistic in experimental and clinical models. We have used etoposide, leucovorin, 5-FU, and CDDP in advanced or recurrent esophageal squamous cell carcinoma since January, 1991, and we evaluate herein the tumor reduction and the postoperative morbidity and mortality.

Keywords

Esophageal Squamous Cell Carcinoma Esophageal Carcinoma Human Granulocyte Colony Stimulate Factor Distant Lymph Node Metastasis Esophageal Squamous Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag Tokyo 1993

Authors and Affiliations

  • Susumu Ohwada
  • Yuichi Iino
  • Seiji Nakamura
  • Yoshihumi Tanahashi
  • Yoshiyuki Kawashima
  • Yukio Miyamoto
  • Yasuo Morishita
    • 1
  1. 1.The Second Department of SurgeryGunma University School of MedicineMaebashi, Gunma, 371Japan

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