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Local Chemotherapy of Esophageal Cancer with Bleomycin Adsorbed to Activated Carbon Particles

  • Mario Shimada
  • Shoji Natsugoe
  • Toru Kumanohoso
  • Takashi Aikou
  • Hisaaki Shimazu
  • Kazuo Nakamura

Abstract

Increasing interest has recently been shown in targeting cancer chemotherapy using newly designed drug delivery systems [1]. Hagiwara et al. [2] developed activated carbon particles as a drug carrier having several advantages such as selective affinity for the lymphatic system and release of a designated fixed concentration of anticancer drug over a long period.

Keywords

Lymph Node Esophageal Cancer Regional Lymph Node Mediastinal Lymph Node Gastric Cardia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Tanigawa N, Satomura K, Hikasa Y, Hashida M, Muranishi S, Sezaki H (1980) Surgical chemotherapy against lymph node metastases. An experimental study. Surgery 87: 147–152PubMedGoogle Scholar
  2. 2.
    Hagiwara A, Ahn T, Ueda T, Iwamoto A, Ueda T, Torii T, Takahashi T (1985) Anticancer agents adsorbed by activated carbon particles: A new form of dosage-enhancing efficacy on lymph nodal metastases. Anti-cancer Research 6: 1005–1008Google Scholar
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    Aikou T, Shimazu H (1989) Difference in main lymphatic pathways from the lower esophagus and gastric cardia. Jpn J Surg 19: 290–295PubMedCrossRefGoogle Scholar
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    Natsugoe S, Aikou T, Shimazu H, Tabata M (1991) Lymphatic anastmoses between the distal esophagus and gastric cardia in dogs. Clinical Anatomy 4: 357–365CrossRefGoogle Scholar
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    Hagiwara A, Takahashi T, Ueda T, Iwamoto A, Torri T (1987) Activated carbon particles as anti-cancer drug carrier into regional lymph nodes. Anti-Cancer Drug Design 1: 313–321PubMedGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1993

Authors and Affiliations

  • Mario Shimada
    • 1
  • Shoji Natsugoe
    • 1
  • Toru Kumanohoso
    • 1
  • Takashi Aikou
    • 1
  • Hisaaki Shimazu
    • 1
  • Kazuo Nakamura
    • 2
  1. 1.First Department of SurgeryKagoshima University School of MedicineKagoshima, 890Japan
  2. 2.Department of Hospital PharmacyKagoshima University School of MedicineKagoshima, 890Japan

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