A New Modality of Chemotherapy in the Treatment of Esophageal Carcinoma Using Angiotensin II-Induced Hypertension and OK-432-Induced Hyperthermia

  • Hideyuki Kawahara
  • Ken Okabayashi
  • Takeshi Shiraishi
  • Yasunori Yoshida
  • Takayuki Shirakusa
Conference paper


In the treatment of patients with malignant tumors of the esophagus, conventional chemotherapeutic regimens have brought little improvement in long-term survival [1–3]. In view of the limited gains resulting from the therapy of these highly lethal diseases, new effective modalities are needed to improve the prognoses. The present report concerns our new method of cancer chemotherapy in combination with angiotensin II—induced hypertension and OK−432—induced hyperthermia (hypertensive-hyperthermo-chemotherapy [HHC]).


Esophageal Carcinoma Adenoid Cystic Carcinoma Bronchogenic Carcinoma Hypertensive State Drip Infusion 


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Copyright information

© Springer-Verlag Tokyo 1993

Authors and Affiliations

  • Hideyuki Kawahara
    • 1
  • Ken Okabayashi
  • Takeshi Shiraishi
  • Yasunori Yoshida
  • Takayuki Shirakusa
    • 2
  1. 1.Kawasaki City Ida HospitalKawasaki, Kanagawa, 211Japan
  2. 2.Department of Thoracic and Cardiovascular SurgeryUniversity of Occupational and Environmental HealthKitakyushu-shi, FukuokaJapan

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