A New Modality of Chemotherapy in the Treatment of Esophageal Carcinoma Using Angiotensin II-Induced Hypertension and OK-432-Induced Hyperthermia
In the treatment of patients with malignant tumors of the esophagus, conventional chemotherapeutic regimens have brought little improvement in long-term survival [1–3]. In view of the limited gains resulting from the therapy of these highly lethal diseases, new effective modalities are needed to improve the prognoses. The present report concerns our new method of cancer chemotherapy in combination with angiotensin II—induced hypertension and OK−432—induced hyperthermia (hypertensive-hyperthermo-chemotherapy [HHC]).
KeywordsEsophageal Carcinoma Adenoid Cystic Carcinoma Bronchogenic Carcinoma Hypertensive State Drip Infusion
Unable to display preview. Download preview PDF.
- 2.Nabeya K (1976) The use of bleomycin in the treatment of carcinoma of the esophagus. Gan Monogr 19: 177–186Google Scholar
- 4.Japanese Society for Esophageal Disease (1989) Guidelines for the clinical and pathologic studies on carcinoma of the esophagus (7th edn) (in Japanese). Kanehara, TokyoGoogle Scholar
- 5.Suzuki M, Hori K, Abe I, Saito S, Sato H (1977) Experimental studies on local permeation of anticancr drugs in tumor tissue. Jpn J Cancer chemother 4: 97–102Google Scholar
- 6.Algire GH, Chalkloy HW (1945) Vascular reactions of normal and malignant tissues in vivo. 1. Vascular reactions of mice to wounds and to normal and neoplastic transplants. J Nat Cancer Inst 6: 73–85Google Scholar