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Computerised Alfentanil Infusion in Postoperative Analgesia

  • Gavin NC Kenny
  • F. W. Davies
  • Martin White
Conference paper

Abstract

Postoperative analgesia is often provided with a continuous intravenous infusion of morphine with the infusion rate altered by the nursing staff as required. However, the time to the peak effect of an intravenous bolus dose of morphine is about 15–20 minutes. A change in the infusion rate of morphine will therefore not achieve its full effect for a considerable period of time, Alfentanil has the main benefit over morphine of rapid onset of action but it also has the disadvantage that it is also rapidly eliminated and re-distributed. Administration by patient controlled analgesia (PCA) has not proved satisfactory [1, 2] and some type of continuous alfentanil infusion is necessary to provide postoperative analgesia.

Keywords

Nursing Staff Postoperative Analgesia Visual Analogue Pain Score Intravenous Bolus Dose Inadequate Analgesia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Kay B. Postoperative pain relief. Use of an on-demand analgesia computer (ODAC) and a comparison of the mode of use of fentanyl and alfentanil. Anaesthesia 1981; 36: 949–951PubMedCrossRefGoogle Scholar
  2. 2.
    Welchew EA, Hosking J. Patient- controlled postoperative analgesia with alfentanil. Adaptive, on-demand intravenous alfentanil or pethidine compared double-blind for postoperative pain. Anaesthesia 1985;40: 1172–1177PubMedCrossRefGoogle Scholar
  3. 3.
    Kenny GNC and White M. A portable computerized infusion system for propofol. Anaesthesia 1990;45: 692–693PubMedCrossRefGoogle Scholar
  4. 4.
    Maitre PO, Vozeh S, Heykants J, Dick TA, Stanski DR. Popuration pharmacokinetics of alfentanil: the average dose-plasma concentration relationship and interindividual variability in patients. Anesthesiology 1987; 66: 3–12PubMedCrossRefGoogle Scholar
  5. 5.
    Andrews CJH, Sinclair M, Prys-Roberts C, Dye A,. Ventilatory effects during and after continuous infusion of fentanyl or alfentanil. Br. J. Anesth. 1983; 55: 211s–216sGoogle Scholar
  6. 6.
    Owen H, Brose WG, Plummer JL, Mather LE. Variables of patient-controlled analgesia. 3: test of an infusion-demand system using alfentanil. Anaesthesia. 1990; 45: 452–455PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1992

Authors and Affiliations

  • Gavin NC Kenny
    • 1
  • F. W. Davies
    • 1
  • Martin White
    • 1
  1. 1.University Department of Anaesthesia Royal Infirmar8-16 Alexandra ParadeGlasgowUK

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