A Simulation Analysis for Optimal Plasma Potassium Concentration during Cardiopulmonary Extracorporeal Bypass
A simulation program to predict optimal plasma potassium ion during cardiopulmonary bypass was constructed from a view point of pharmacokinetics. Experimental results of sodium-22 and data of urinary excretion during cardiac surgeries were used in the model. The change of plasma potassium ion concentration, which was obtained from accidental administrations of KCl showed good agreement with this model. The results of this simulation model provide an useful information to infuse KC1 for the supplement in a condition of hypokalemia such as cardiopulmonary bypass.
KeywordsCardiac Arrest Cardiopulmonary Bypass Diffusion Constant Potassium Concentration Plasma Potassium
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