A 24-Hour Prediction Model of Blood Pressure Employing Endocrine System and Autonomic Nervous System
Hypertension is a medical problem with no permanent cure. Extended hypertension can cause various cardio vascular diseases, cerebral vascular diseases, and circulatory system trouble. Medical treatment at present does not consider circadian variation of blood pressure in patients; therefore, the problem of over-reduction of blood pressure through drugs sometimes occurs. It is important for preventing damage to internal organs that the blood pressure variation is predicted after drug administration. If it can be predicted, a proper medical treatment, including drugs, can be given.
This paper presents a prediction model of circadian variation of mean blood pressure employing the endocrine grand and the autonomic nervous system. Heart rate and mean blood pressure in 17 normal subjects and 17 essential hypertensive subjects are simulated by employing a model. The absolute errors between simulation results and measured values are calculated to evaluate the model.
The results showed that absolute errors between simulation results and measured values were less than 10 percent compared to mean blood pressure and heart rate at rest. It is thus confirmed that the model is useful to predict circadian variation of heart rate and mean blood pressure.
KeywordsStroke Volume Absolute Error Autonomic Nervous System Adrenal Cortex Peripheral Resistance
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- K. Shimazu, “Clinical usefulness in ambulatory blood pressure measurement,” “in Japanese,” THERAPEUTIC RESERCH, vol.11, pp.40–46, 1990.Google Scholar
- W. F. Ganong, (Traslated by K. Matsuda, M. Ichioka, T. Azuma, H. Hayashi, T. Kanno, Y. Nakamura, A. Sato), “Review of Medical Physiology 13th Edition,” Tokyo, Maruzen, 1988, Chapter 4, pp.418Google Scholar
- S. Ito, M. Kawakami, “Adaptation andcerebral hormone” “in Japanese,” Tokyo, Rikougakusya, 1979, Chapter 11, pp.223Google Scholar
- W. F. Ganong (Traslated by K. Matsuda, M. Ichioka, T. Azuma, H. Hayashi, T. Kanno, Y. Nakamura, A. Sato), “Review of Medical Physiology 13th Edition,” Tokyo, Maruzen, 1988, Chapter 4, pp.345Google Scholar
- K. Yagi, S. Yoshida, “Handbook of Physiological Sciences Vol.14 Physiology of Neuroendocrine System,” Tokyo, Igaku- Shoin Ltd, 1988, Chapter 6, pp.226Google Scholar
- N. Toida, K. Uchizono, “TEXTBOOK OF MODERN PHYSIOLOGY Volume 2,” Tokyo, Igaku-Shoin Ltd, 1975, Chapter 12, pp,621AGoogle Scholar