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The Application of SALS (Statistical Analysis with the Least Square) to Michaelis-Menten Pharmacokinetics of Phenytoin

  • Sinichi Nishi
  • Akira Asada
  • Yutaka Oda
  • Noriko Yoshida
  • Junko Abe
  • Mitsugu Fujimori
Conference paper

Abstract

Phenytoin is a common drug as an anticonvulsant. The therapeutic drug monitoring is required for phenytoin because of its narrow therapeutic range. The metabolism of phenytoin is saturated within the clinical doses. The saturation kinetics can be evaluated by two parameters, Vmax, maximal metabolic velocity and Km, Michaelis-Menten constant.

Keywords

Therapeutic Drug Monitoring Hepatic Blood Flow Mean Residence Time Intrinsic Clearance Mini Computer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Tokyo 1992

Authors and Affiliations

  • Sinichi Nishi
    • 1
  • Akira Asada
    • 1
  • Yutaka Oda
    • 1
  • Noriko Yoshida
    • 1
  • Junko Abe
    • 1
  • Mitsugu Fujimori
    • 1
  1. 1.Department of Anesthesiology and Intensive Care MedicineOsaka City University Medical SchoolOsaka 545Japan

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