Use of the Coagulation Monitor 512 for Reversal of Heparin-Induced Anticoagulation and the Effect of Fresh Frozen Plasma
Anticoagulation levels during cardiopulmonary (CP) bypass vary widely. Therefore, monitoring anticoagulation responses to heparin by repeated anticoagulation testing is mandatory during CP bypass. Until recently Activated Coagulation Time (ACT) has been used. Activated partial thrombin time (APTT) and prothrombin time (PT) have seldom been used for monitoring heparin-induced anticoagulation because former APTT and PT methods took too much time, required a lot of skills to carry out, and the amount of sample needed was too much. After heparin reversal APTT and PT are considered to be a more accurate way of monitoring the patient than ACT. We wanted to evaluate the use of the 512 as a monitor during cardiac surgery operations and to investigate the effect of Fresh Frozen Plasma (FFP) on APTT and PT after CP bypass.