Summary
The pathogenesis of mechanically induced arthrosis is due to a disproportion between the physiological resistance of the supporting tissue and the compressive stress developing in the joint. Those mechanical factors contributing to an increase in articular pressure are (1) a rise in the magnitude of the resultant force during movement, (2) a reduction of the pressure-transmitting articular surface, and (3) an eccentric position of the resultant force. Cluster formation, subchondral bone sclerosis, and osteophyte formation are reparation attempts made in the course of osteoarthrosis. Osteophytes are of chondral osteogenesis and they are subjected to stress by compressive forces. In considering the problem of the etiopathogenesis of osteoarthrosis, STR/lN-mice are included in current investigations because in this arthrosis model there are two different types of osteoarthrosis; one due to a biomechanically-induced instability (patellar luxation) and one due to biochemical changes (absence of keratan sulfate) in the articular cartilage. Polychrome sequential labeling is used to study the dynamics of subchondral bone sclerosis during developing osteoarthrosis in the knee joints of STR/lN-mice. The results indicate that subchondral sclerosis is caused by cartilage lesion, and that even slight changes of hyaline cartilage may initiate proliferation of the subchondral bone.
Dedicated to Professor Dr. K. Hirohata, with compliments
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Wagenhäuser FJ (1968) Die Rheuma-Morbiditat, eine klinisch-epidemiologische Untersuchung. Huber, Bern
Roughley PJ, Mort JS (1986) Aging and the aggregating proteoglycans of human articular cartilage. Clin Sci 71:331–344
Thonar EJMA, Bjornsson S, Kuettner KE (1986) Age-related changes in cartilage proteoglycans. In: Kuettner K, Schleyerbach R, Hascall VC (eds) Articular cartilage biochemistry. Raven, New York, pp 273–291
Gyarmati J, Földer I, Kern M, Kiss I (1987) Morphological studies on the articular cartilage of old rats. Acta Morphol Hung 35:111–124
Bayliss MT (1986) Proteoglycan structure in normal and osteoarthrotic human cartilage. In: Kuettner K, Schleyerbach R, Hascall VC (eds) Articular cartilage biochemistry. Raven, New York, pp 295–310
Poole AR (1986) Proteoglycans in health and disease: structure and functions. Biochem J 236: 1–14
Muir H (1977) Molecular approach to the understanding of osteoarthrosis. Ann Rheum Dis 36: 199–208
Pauwels F (1976) Biomechanics of the normal and diseased hip. Springer, Berlin Heidelberg New York
Kummer B (1969) Die Beanspruchung der Gelenke, dargestellt am Beispiel des menschlichen Hüftgelenkes. Verh Dtsch Ges Orthop, Enke, pp 301–311
Maquet PGJ (1976) Biomechanics of the Knee. Springer, Berlin
Tillmann B, Tichy P, Schleicher A (1986) Biomechanik des VorfuBes unter besonderer Benücksichtigung des Hallux valgus. In: Blauth (Hrsg) Der Hallux valgus. Springer, Berlin Heidelberg New York Tokyo, pp 27–36
Tillmann B (1978) A contribution to the functional morphology of articular surfaces. In: Bargmann W, Doerr W (eds) Normale und Pathologische Anatomie, vol 34. Thieme, Stuttgart
Grasset EJ (1960) La Coxarthrose. Masson, Paris
Bombelli R (1976) Osteoarthritis of the hip, Springer, Berlin Heidelberg New York
Carstens C, Tillmann B (1983) Zur Beanspruchung der Osteophyten bei der Coxarthrose. Verh Anat Ges 77:319–320
Tillmann B, Schünke M (1991) Struktur and Funktion extrazellulärer Matrix. Verh Anat Ges 84:23–36
Schünke M, Tillmann B, Briick M, Muller-Ruchholtz W (1988) Lectin-binding in normal and osteoarthrotic articular cartilage from STR/lN-mouse knee joints. Virchows Arch [Cell Pathol] 54:327–333
Walton M (1977) Degenerative joint disease in the mouse knee: histological observations. J Pathol 123:109–122
Wilhelmi G (1981) Morphological observations on proliferation and regeneration processes in spontaneous osteoarthrosis in the C57 black mouse. In: Peyron JG (ed) New research developments in osteoarthrosis. Huber, Bern
Schünke M, Tillmann B, Bruck M, Muller-Ruchholtz W (1988) Morphologic characteristics of developing osteoarthrotic lesions in the knee cartilage of STR/1N mice. Arthritis Rheum 31: 898–905
Venn G, Mason RM (1985) Absence of keratan sulfate from skeletal tissues of mouse and rat. Biochem J 228:443–450
Rostand KS, Baker JR, Caterson B, Christner JE (1986) Articular cartilage proteoglycans from normal and osteoarthritic mice. Arthritis Rheum 29:95–105
Benske B, Schünke M, Tillmann B (1988) Subchondral bone formation in arthrosis. Polychrome labeling studies in mice. Acta Orthop Scand 59: 536–541
Rahn BA (1976) Die polychrome Sequenzmarkierung des Knochens. Nova Acta Leopoldina 44:249–255
Radin EL, Rose RM (1986) Role of subchondral bone in the initiation and progression of cartilage damage. Clin Orthop 213:34–40
Maroudas A (1976) Balance between swelling pressure and collagen tension in normal and degenerated cartilage. Nature 260:808–809
Tillmann B (1980) Pathomechanics of articular surfaces. In: Gastpar H (ed) Biology of the articular cartilage in health and disease. Schattauer, pp 155–171
Hulth A (1988) Growth factors in arthrosis. Acta Orthop Scand 59(5):594
Canalis E, McCarthy T, Contrella M (1988) Growth factors and the regulation of bone remodeling. J Clin Invest 81:277–281
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag Tokyo
About this chapter
Cite this chapter
Tillmann, B., Schünke, M. (1992). Pathology of Osteoarthrosis. In: Hirohata, K., Mizuno, K., Matsubara, T. (eds) Trends in Research and Treatment of Joint Diseases. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68192-2_3
Download citation
DOI: https://doi.org/10.1007/978-4-431-68192-2_3
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68194-6
Online ISBN: 978-4-431-68192-2
eBook Packages: Springer Book Archive