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Pathophysiology of Osteoarthritis

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Trends in Research and Treatment of Joint Diseases

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Summary

The etiopathogenesis of osteoarthritis is complex. Genetic factors may influence the macromolecules constituting cartilage and other joint tissues. The normal tissue remodeling process may be altered by mechanical factors, by hormones, or by particulates such as wear particles and/or crystals which have biological influences on cells. These factors may accelerate the catabolic arm of tissue remodeling to the point where anabolic synthesis is overwhelmed, producing irreversible or only partially reversible damage, which is perceived clinically as joint degeneration.

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Author information

Authors and Affiliations

  1. The Arthritis Institute and Division of Rheumatology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, 53226, USA

    Daniel J. McCarty

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  1. Daniel J. McCarty
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Editor information

Editors and Affiliations

  1. Department of Orthopedic Surgery, Kobe University School of Medicine, Chuo-ku, Kobe, 650, Japan

    Kazushi Hirohata M.D. (Chairman of Orlhopedic Surgery), Kosaku Mizuno M.D.  & Tsukasa Matsubara M.D. (Chairman of Orlhopedic Surgery),  & 

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© 1992 Springer-Verlag Tokyo

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McCarty, D.J. (1992). Pathophysiology of Osteoarthritis. In: Hirohata, K., Mizuno, K., Matsubara, T. (eds) Trends in Research and Treatment of Joint Diseases. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68192-2_2

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  • DOI: https://doi.org/10.1007/978-4-431-68192-2_2

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68194-6

  • Online ISBN: 978-4-431-68192-2

  • eBook Packages: Springer Book Archive

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