Multidisciplinary treatment of hepatocellular carcinoma
Approximately 90% of hepatocellular carcinoma (HCC) in Japan is associated with chronic liver diseases (mostly liver cirrhosis) and development in the liver is considered to be multicentric. In addition, vascular invasion occurs in the early stages. For these reasons, even small HCC occasionally cannot be removed surgically, and thus, the treatment of HCC is remarkably different from other malignancies. Our studies have indicated that 33.5% of 200 cases of small HCC less than 2 cm in diameter are multinodular , and there were recurrent tumors in most cases 5 years after initial successful treatment with surgical resection or percutaneous ethanol injection therapy (PEIT). Autopsy studies have also shown that a high frequency of extrahepatic metastasis is observed in cases with tumors more than 5 cm in diameter. Thus, surgical resection, the preferred treatment of malignancies, is limited.
KeywordsMultidisciplinary Treatment Extrahepatic Metastasis Lymphokine Activate Killer Small Hepatocellular Carcinoma Partial Splenic Embolization
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