Abstract
The liver has a dual blood supply by the arterial and portal systems. Primary and secondary liver tumors are mainly nourished arterially, as first suggested by Breedis and Young [1]. This knowledge has guided numerous attempts to affect the growth of liver tumors by reduction of the nutritive arterial flow and/or addition to it of antitumor agents. In both cases, some selectivity of action is expected because the normal liver is to a great extent also supplied by the portal venous flow. The regional infusion of toxic agents could be expected to give diminished side effects as compared to systemic treatment because the agents may be more or less cleared or modified by passage through the liver.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Breedis C, Young G (1954) The blood supply of neoplasms in the liver. Am J Pathol 30: 969–985
Sugarbaker PH, Kemeny N (1989) Treatment of metastatic cancer to liver. In: DeVita Jr VT, Hellman S, Rosenberg SA (eds) Cancer. Principles and practice of oncology (3rd edn) J B Lippincott, Philadelphia, pp 2275–2298
del Giglio A, Zukiwski AA, Ali MK, Mavligit GM (1991) Severe, symptomatic, dose-limiting hypophosphatemia induced by hepatic arterial infusion of recombinant tumor necrosis factor in patients with liver metastases. Cancer 67: 2459–2461
Bengmark S, Rosengren K (1970) Angiographic study of the collateral circulation to the liver after ligation of the hepatic artery in man. Am J Surg 119: 620–624
Bengmark S, Jeppson B, Lunderquist A, Tranberg KG, Persson B (1988) Tumor calcification following repeated hepatic dearterialization in patients: A preliminary communication. Br J Surg 75: 525–526
Shimamura Y, Gunvén P, Takenaka Y, Shimizu H, Shima Y, Akimoto H, Arima K, Takahashi A, Kitaya T, Matsuyama T, Hasegawa H (1988) Combined peripheral and central chemoembolization of liver tumors. Experience with Lipiodol-doxorubicin and gelatin sponge ( L-TEA ). Cancer 61: 238–242
Caron J, Laval-Jeantet M, Lamarque JL, Huguet JF, Caron-Poitreau C (1973) Exploration artériographique des cancers secondaires du foie: Intérêt des iodo-lipides par injection artérielle. Sem Hôp Paris 50: 3367–3376
Nakakuma K, Tashiro S, Hiraoka T, Ogata K, Ootsuka K (1985) Hepatocellular carcinoma and metastatic cancer detected by iodized oil. Radiology 154: 15–17
Ohishi H, Uchida H, Yoshimura H, Ohue S, Ueda J, Katsuragi M, Matsuo N, Hosogi Y (1985) Hepatocellular carcinoma detected by iodized oil: Use of anticancer agents. Radiology 154: 25–29
Yumoto Y, Jinno K, Tokuyama K, Araki Y, Ishimatsu T, Maeda H, Konno T, Iwamoto S, Ohnishi K, Okuda K (1985) Hepatocellular carcinoma detected by iodized oil, Radiology 154: 19–24
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag Tokyo
About this chapter
Cite this chapter
Shimamura, Y. et al. (1992). Arterial infusion therapy: Lipiodol-cytostatics with and without embolization. In: Tobe, T., et al. Primary Liver Cancer in Japan. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68177-9_26
Download citation
DOI: https://doi.org/10.1007/978-4-431-68177-9_26
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68179-3
Online ISBN: 978-4-431-68177-9
eBook Packages: Springer Book Archive