Summary
This study was designed to determine the regional cerebral blood flow (rCBF), somatosensory evoked potentials (SEPs), pressure volume index (PVI), and resistance to absorption of cerebrospinal fluid (Ro) in different stages of kaolin-induced hydrocephalus. The experimental animals (cats) were divided into 2 groups; a normal control, and a kaolin-induced hydrocephalic group.
The kaolin-induced hydrocephalic group was divided into 5 subgroups of 10 cats each. These subgroups consisted of cats at 1, 2, 4, 6, and 8 weeks after intracisternal injection of kaolin. Significant decreases in rCBF were revealed both in the frontal cortex and in the periventricular area of kaolin-induced hydrocephalic cats. A reduction of rCBF to 24.7% of control flow (20.4 ± 2.8 ml per 100g per min) was detected in the right periventricular area at 2 weeks after kaolin injection. Changes of amplitude and latency in SEPs were more prominent 4 weeks after kaolin injection. The PVI increased significantly from 0.77 ± 0.02 ml to 1.60 ± 0.16 ml at 4 weeks after kaolin injection. Ro decreased significantly from 90.6 ± 1.3 mmHg per ml per min to 36.8 ± 4.3 mmHg per ml per min at 4 weeks after kaolin injection. It is assumed that some microcirculatory impairment in the brain parenchyma plays an important role which facilitates ventricular expansion with changes of the biomechanical properties of the brain.
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References
Asada M, Tamaki N, Kanazawa Y, Matsumoto S, Matsuo M, Kimura S, Fujii S, Kanada Y (1978) Computer analysis of periventricular lucency on the CT scan. Neuroradiology 16: 207–211
Bering EA Jr, Sato O (1963) Hydrocephalus: changes in formation and absorption of cerebrospinal fluid within the cerebral ventricles. J Neurosurg 20: 1050–1063
Drapkin AJ, Sahar A (1978) Experimental hydrocephalus: cerebrospinal fluid dynamics and ventricular distensibility during early stages. Childs Brain 4: 278–288
Fried A, Shapiro K, Takei F, Kohn I (1987) A laboratory model of shunt-dependent hydrocephalus: development and biomechanical characterization. J Neurosurg 66: 734–740
Greitz T (1969) Effect of brain distension on cerebral circulation. Lancet I: 863–865
Guinane JE (1974) Cerebrospinal fluid resistance and compliance in subacutely hydrocephalic cats. Neurology 24: 138–142
Hochwald GM, Lux WB Jr, Sahar A (1972a) Experimental hydrocephalus: Changes in cerebrospinal fluid dynamics as a function of time. Arch Neurol 26: 120–129
Hochwald GM, Epstein F, Malhan C (1972b) The role of the skull and dura in experimental feline hydrocephalus. Dev Med Child Neurol 14 (Suppl 27): 65–69
Hochwald GM, Epstein F, Malhan C (1973) The relationship of compensated to decompensated hydrocephalus in the cat. J Neurosurg 39: 694–697
Hochwald GM, Boal RD, Marlin AE, Kumar AJ (1975) Changes in regional blood flow and water content of brain and spinal cord in acute and chronic experimental hydrocephalus. Dev Med Child Neurol [Suppl] 17: 42–50
Löfgren J, von Essen C, Zwetnow NN (1973) The pressure-volume curve of the cerebrospinal fluid space in dogs. Acta Neurol Scand 49: 557–574
Marmarou A, Shulman K, MaMorgese J (1975) Compartmental analysis of compliance and outflow resistance of the cerebrospinal fluid system. J Neurosurg 43: 523–535
Matthew NT, Meyer JS, Hartmann A, Ott EO (1975) Abnormal cerebrospinal fluidblood flow dynamics. Implications in diagnosis, treatment, and prognosis in normal pressure hydrocephalus. Arch Neurol 32: 644–657
McLone DG, Bondareff W, Raimondi AJ (1971) Brain edema in the hydrocephalic hy-3 mouse: Submicroscopic morphology. J Neuropathol Exp Neurol 30: 627–637
Milhorat TM, Clark RG, Hammock MK, McGrath PP (1971) Structual, ultrastructural, and permeability changes in the ependyma and surrounding brain favoring equilibration in progressive hydrocephalus. Arch Neurol 22: 397–407
Mori K, Handa H, Murata T, Nakano Y (1980) Periventricular lucency in computed tomography of hydrocephalus and cerebral atrophy. J Comp Assist Tomogr 4: 204–210
Murata T, Yamagata S, Mori K, Handa H, Nakano Y (1980) Computed tomography in experimental canine hydrocephalus. Part 4: periventricular lucency (PVI) and regional cerebral blood flow in the chronic stage of hydrocephalus. Brain Nerve 32: 219–227
Naidich TP, Epstein F, Lin JP, Kricheff II, Hochwald GM (1976) Evaluation of pediatric hydrocephalus by computed tomography. Radiology 119: 337–345
Nakamura S, Camins MB, Hochwald GM (1983) Pressure absorption responses to the infusion of fluid into the spinal cord central canal of kaolin-hydrocephalic cats. J Neurosurg 58: 198–203
Pasztor E, Symon L, Dorsch NWC (1973) The hydrogen clearance method in assessment of blood flow in cortex, white matter and deep nucleus of baboons. Stroke 4: 556–557
Rubin RC, Hochwald GM, Tiell M (1976) Hydrocephalus: I. Histological and ultrastructural changes in the preshunted cortical mantle. Surg Neurol 5: 109–114
Sato O, Ohya M, Nojiri K, Tsugane R (1984) Microcirculatory changes in experimental hydrocephalus: morphological and physiological studies. In: Shapiro K, Marmarou A, Portnoy HP (eds) Hydrocephalus. Raven, New York, pp 215–230
Shapiro K, Fried A, Marmarou A (1985a) Biomechanical and hydrodynamic characterization of the hydrocephalic infant. J Neurosurg 63: 69–75
Shapiro K, Fried A, Takei F, Kohn I (1985b) Effect of the skull and dura on neural axis pressure-volume relationships and CSF hydrodynamics. J Neurosurg63: 76–81
Shulman K, Marmarou A (1971) Pressure-volume considerations in infantile hydrocephalus. Dev Med Child Neurol 13(Suppl 25): 90–95
Takei F, Shapiro K, Kohn I (1987) Influence of the rate of ventricular enlargement on the white matter water content in progressive feline hydrocephalus. J Neurosurg 66: 577–583
Torvik A, Murthy VS (1977) The spinal cord central canal in kaolin-induced hydrocephalus. J Neurosurg 47: 397–402
Weiler RO, Williams BN (1975) Cerebral biopsy and assessment of brain damage in hydrocephalus. Arch Dis Child 50: 763–768
Weiler RO, Wisniewski H (1969) Histological and ultrastructural changes with experimental hydrocephalus in adult rabbits. Brain 92: 819–828
Yakovlev PI (1947) Paraplegias of hydrocephalies. Am J Ment Defic 51: 561–576
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© 1991 Springer-Verlag Tokyo
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Kang, J.K. et al. (1991). Effects of Ventricular Enlargement of Experimental Hydrocephalus on the Regional Cerebral Blood Flow, Somatosensory Evoked Potentials, and Biomechanical Factors. In: Matsumoto, S., Tamaki, N. (eds) Hydrocephalus. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68156-4_11
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DOI: https://doi.org/10.1007/978-4-431-68156-4_11
Publisher Name: Springer, Tokyo
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