The LEC Rat pp 87-94 | Cite as

Sensitivity of LEC Rats to the Hepatotoxic Effects of D-Galactosamine

  • Hidetoshi Takahashi
  • Katsuhiko Enomoto
  • Hirofumi Sakamoto
  • Hirotoshi Tobioka
  • Kimimaro Dempo
  • Michio Mori


Spontaneous hepatitis in the LEC rat is characterized by hyperbilirubinemia, increased levels of serum glutamic-oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) in laboratory examination and spotty coagulative necrosis of single hepatocyte without inflammatory cell response [1, 2]. Although a single autosomal recessive gene (hts) has been shown to be responsible for the hepatitis, the mechanism(s) of hepatocyte necrosis in the LEC rat remains obscure. The histological features of the liver reveal a certain resemblance between the hepatitis of LEC rats and the liver necrosis induced by the administration of D-galactosamine (GalN).


Glutamic Pyruvic Transaminase Allyl Alcohol Coagulative Necrosis Serum Glutamic Pyruvic Transaminase Hepatotoxic Effect 
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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Hidetoshi Takahashi
  • Katsuhiko Enomoto
  • Hirofumi Sakamoto
  • Hirotoshi Tobioka
  • Kimimaro Dempo
  • Michio Mori
    • 1
  1. 1.Department of PathologySapporo Medical CollegeSapporo, 060Japan

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