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Possible Involvement of Abnormal Cytokinesis and Karyokinesis in the Manifestation of Hepatitis in LEC Rats

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The LEC Rat

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Abstract

In jaundiced LEC rats, the histopathological characteristics of the liver include markedly enlarged hepatocytes with huge nuclei whose DNA content appears to be more than octaploid. At the age of 14 weeks, immediately prior to the onset of hepatitis, the nuclei of hepatocytes often vary in size, and their enlarged nuclei frequently possess several nucleoli. Based upon these observations, we have analyzed nuclei ploidy, the percentage of binucleated cells, and DNA synthesis in the hepatocytes of LEC rats at various ages in order to determine whether abnormal cytokinesis and karyokinesis occur in LEC rats [1, 2].

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References

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Author information

Authors and Affiliations

  1. Department of Pathology, Sapporo Medical College, Sapporo, 060, Japan

    Yoshinori Fujimoto & Michio Mori

  2. Carcinogenesis Division, National Cancer Center Research Institute, Chuo-Ku, Tokyo, 104, Japan

    Yoshinori Fujimoto & Minako Nagao

  3. Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA

    Yoshinori Fujimoto

Authors
  1. Yoshinori Fujimoto
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  2. Michio Mori
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  3. Minako Nagao
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Editor information

Editors and Affiliations

  1. Department of Pathology, Sapporo Medical College, Minami 1, Nishi 17, Chuo-ku, Sapporo, 060, Japan

    Michio Mori M.D., Ph.D.

  2. Chromosome Research Unit, Faculty of Science, Hokkaido University, Kita 10, Nishi 8, Kita-ku Sapporo, 060, Japan

    Michihiro C. Yoshida D.Si., Ph.D.

  3. Laboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo, 060, Japan

    Noritoshi Takeichi M.D., Ph.D.

  4. Department of Biochemistry, Osaka University Medical School, 2–2 Yamadaoka, Suita, Osaka, 565, Japan

    Naoyuki Taniguchi M.D., Ph.D.

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© 1991 Springer-Verlag Tokyo

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Fujimoto, Y., Mori, M., Nagao, M. (1991). Possible Involvement of Abnormal Cytokinesis and Karyokinesis in the Manifestation of Hepatitis in LEC Rats. In: Mori, M., Yoshida, M.C., Takeichi, N., Taniguchi, N. (eds) The LEC Rat. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68153-3_8

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  • DOI: https://doi.org/10.1007/978-4-431-68153-3_8

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68155-7

  • Online ISBN: 978-4-431-68153-3

  • eBook Packages: Springer Book Archive

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