Abstract
Currently, there are very few available animal models for the research of human hepatitis. We have known for many years that the marmoset and the chimpanzee are sensitive to hepatitis A and B viruses, respectively. It has been reported that the woodchunk (Marmota monax) shows a high incidence of persistent infection with woodchuck hepatitis virus (WHV), one of the hepadna viruses, and that the incidence of hepatocellular carcinomas in WHV-positive woodchucks is extremely high [1].
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References
Summers J, Smolec JM, Smyder R (1978) A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks. Proc Natl Acad Sci USA 75:4533–4537.
Sasaki M, Yoshida MC, Kagami K, Takeichi N, Kobayashi H, Dempo K, Mori M (1985) Spontaneous hepatitis in an inbred strain of Long-Evans rats. Rat News Lett 14:4–6.
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© 1991 Springer-Verlag Tokyo
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Namieno, T. et al. (1991). Clinical and Pathological Characteristics of LEC Rats with Spontaneous Hepatitis. In: Mori, M., Yoshida, M.C., Takeichi, N., Taniguchi, N. (eds) The LEC Rat. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68153-3_5
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DOI: https://doi.org/10.1007/978-4-431-68153-3_5
Publisher Name: Springer, Tokyo
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