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The LEC Rat pp 41–53Cite as

Clinical and Pathological Characteristics of LEC Rats with Spontaneous Hepatitis

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Abstract

Currently, there are very few available animal models for the research of human hepatitis. We have known for many years that the marmoset and the chimpanzee are sensitive to hepatitis A and B viruses, respectively. It has been reported that the woodchunk (Marmota monax) shows a high incidence of persistent infection with woodchuck hepatitis virus (WHV), one of the hepadna viruses, and that the incidence of hepatocellular carcinomas in WHV-positive woodchucks is extremely high [1].

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References

  1. Summers J, Smolec JM, Smyder R (1978) A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks. Proc Natl Acad Sci USA 75:4533–4537.

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  2. Sasaki M, Yoshida MC, Kagami K, Takeichi N, Kobayashi H, Dempo K, Mori M (1985) Spontaneous hepatitis in an inbred strain of Long-Evans rats. Rat News Lett 14:4–6.

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  3. Yoshida MC, Masuda R, Sasaki M, Takeichi N, Kobayashi H, Dempo K, Mori M (1987) New mutation causing hereditary hepatitis in the laboratory rat. J Hered 78:361–365.

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  4. Gunn CK (1938) Hereditary acholuric jaundice in a new mutant strain of rats. J Hered 29:137–141.

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Author information

Authors and Affiliations

  1. Laboratory of Pathology, Cancer Institute, Japan

    Tsutomu Namieno & Hiroshi Kobayashi

  2. First Department of Surgery, School of Medicine, Japan

    Tsutomu Namieno, Noritoshi Takeichi & Jun-ichi Uchino

  3. Sasaki Cancer Institute, Chiyoda-ku, Tokyo, 56, Japan

    Motomichi Sasaki

  4. Department of Pathology, Sapporo Medical College, Sapporo, 060, Japan

    Kimimaro Dempo & Michio Mori

Authors
  1. Tsutomu Namieno
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  2. Noritoshi Takeichi
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  3. Motomichi Sasaki
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  4. Kimimaro Dempo
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  5. Michio Mori
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  6. Jun-ichi Uchino
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  7. Hiroshi Kobayashi
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Editor information

Editors and Affiliations

  1. Department of Pathology, Sapporo Medical College, Minami 1, Nishi 17, Chuo-ku, Sapporo, 060, Japan

    Michio Mori M.D., Ph.D.

  2. Chromosome Research Unit, Faculty of Science, Hokkaido University, Kita 10, Nishi 8, Kita-ku Sapporo, 060, Japan

    Michihiro C. Yoshida D.Si., Ph.D.

  3. Laboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo, 060, Japan

    Noritoshi Takeichi M.D., Ph.D.

  4. Department of Biochemistry, Osaka University Medical School, 2–2 Yamadaoka, Suita, Osaka, 565, Japan

    Naoyuki Taniguchi M.D., Ph.D.

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© 1991 Springer-Verlag Tokyo

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Namieno, T. et al. (1991). Clinical and Pathological Characteristics of LEC Rats with Spontaneous Hepatitis. In: Mori, M., Yoshida, M.C., Takeichi, N., Taniguchi, N. (eds) The LEC Rat. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68153-3_5

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  • DOI: https://doi.org/10.1007/978-4-431-68153-3_5

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68155-7

  • Online ISBN: 978-4-431-68153-3

  • eBook Packages: Springer Book Archive

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