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The LEC Rat pp 41-53 | Cite as

Clinical and Pathological Characteristics of LEC Rats with Spontaneous Hepatitis

  • Tsutomu Namieno
  • Noritoshi Takeichi
  • Motomichi Sasaki
  • Kimimaro Dempo
  • Michio Mori
  • Jun-ichi Uchino
  • Hiroshi Kobayashi

Abstract

Currently, there are very few available animal models for the research of human hepatitis. We have known for many years that the marmoset and the chimpanzee are sensitive to hepatitis A and B viruses, respectively. It has been reported that the woodchunk (Marmota monax) shows a high incidence of persistent infection with woodchuck hepatitis virus (WHV), one of the hepadna viruses, and that the incidence of hepatocellular carcinomas in WHV-positive woodchucks is extremely high [1].

Keywords

Acute Hepatitis Fulminant Hepatitis Human Hepatitis Woodchuck Hepatitis Virus Subcutaneous Hemorrhage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Summers J, Smolec JM, Smyder R (1978) A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks. Proc Natl Acad Sci USA 75:4533–4537.PubMedCrossRefGoogle Scholar
  2. 2.
    Sasaki M, Yoshida MC, Kagami K, Takeichi N, Kobayashi H, Dempo K, Mori M (1985) Spontaneous hepatitis in an inbred strain of Long-Evans rats. Rat News Lett 14:4–6.Google Scholar
  3. 3.
    Yoshida MC, Masuda R, Sasaki M, Takeichi N, Kobayashi H, Dempo K, Mori M (1987) New mutation causing hereditary hepatitis in the laboratory rat. J Hered 78:361–365.PubMedGoogle Scholar
  4. 4.
    Gunn CK (1938) Hereditary acholuric jaundice in a new mutant strain of rats. J Hered 29:137–141.Google Scholar

Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Tsutomu Namieno
    • 1
    • 2
  • Noritoshi Takeichi
    • 2
  • Motomichi Sasaki
    • 3
  • Kimimaro Dempo
    • 4
  • Michio Mori
    • 4
  • Jun-ichi Uchino
    • 2
  • Hiroshi Kobayashi
    • 1
  1. 1.Laboratory of PathologyCancer InstituteJapan
  2. 2.First Department of SurgerySchool of MedicineJapan
  3. 3.Sasaki Cancer InstituteChiyoda-ku, Tokyo, 56Japan
  4. 4.Department of PathologySapporo Medical CollegeSapporo, 060Japan

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