The LEC Rat pp 341-348 | Cite as

Chromosomal Mapping of the Placental Glutathione S-Transferase Gene and Its Expression in Livers of LEC Rats

  • Ryuichi Masuda
  • Michihiro C. Yoshida
  • Motomichi Sasaki


The LEC strain rat is a new mutant which suddenly suffers from fulminant hepatitis at about 4 months of age [1, 2]. A crossing test of LEC rats showed that the hepatitis has an autosomal recessive mode of inheritance ruled by a single gene designated hts [3]. About 30% of the animals died of the disease within 1 week after onset. The remaining 70% survived with chronic hepatitis for more than 1 year and developed well-differentiated hepatocellular carcinomas (hepatomas) together with cholangiofibrosis at a remarkably high incidence [4]. Therefore, it is important to clarify what are the characteristics of hepatic lesions in LEC rats.


Chronic Hepatitis Hepatic Lesion Fulminant Hepatitis Autosomal Recessive Mode Chemical Hepatocarcinogenesis 
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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Ryuichi Masuda
    • 1
  • Michihiro C. Yoshida
    • 1
  • Motomichi Sasaki
    • 2
  1. 1.Chromosome Research Unit, Faculty of ScienceHokkaido UniversitySapporo, 060Japan
  2. 2.Sasaki Cancer InstituteChiyoda-ku, Tokyo, 101Japan

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